Preclinical News and Research

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Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Multimodal-Spectroscopy research team in the Biomedical Optics Research Laboratory at the Medical Physics and Biomedical Engineering department at University College London led by Dr IliasTachtsidis has designed CYRIL, a compact broadband near-infrared spectroscopy(NIRS) system, to monitor brain tissue physiology non-invasively in newborn babies.

15 Nov 2017

Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows

Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc., to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation.

14 Nov 2017

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

10 Nov 2017

Study identifies promising treatment to reduce brain injury in babies

Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen.

10 Nov 2017

OSA may put elderly people at increased risk of developing Alzheimer's disease

Obstructive sleep apnea (OSA) may put elderly people at greater risk of developing Alzheimer's disease (AD), according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

10 Nov 2017

Aspect Imaging announces receipt of CE marking for neonatal-dedicated MRI system

Aspect Imaging, a developer of compact high-performance MRI systems, announces today that it has received CE marking for the neonatal-dedicated MRI system, Embrace Neonatal MRI System, which enables preparation and scanning of newborns, without having to transport them from the NICU. Embrace® Neonatal MRI can now be used and sold in EU countries and in non-EU countries that rely on CE certification.

9 Nov 2017

New gene therapy trial for X-linked myotubular myopathy offers hope to children

Ann & Robert H. Lurie Children's Hospital of Chicago is one of the few centers participating in ASPIRO, an international Phase 1/2 clinical trial of a gene therapy product called AT132 for X-linked myotubular myopathy – a rare disease characterized by severe muscle weakness, breathing difficulty and early death.

8 Nov 2017

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a new protective function for a brain protein genetically linked to Alzheimer's. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies.

7 Nov 2017

Researchers identify new neuroprotective factor that holds potential to help people with glaucoma

A research team led by scientists at the Krembil Research Institute in Toronto has identified a new neuroprotective factor that has the potential to help people suffering from the common blinding disease glaucoma.

7 Nov 2017

Study shows hemodynamic and metabolic changes up to 7 days after traumatic spinal cord injury

Researchers have shown that some of the critical pathophysiological responses to traumatic spinal cord injury (SCI), evidence of insufficient oxygen levels and metabolic stress that can permanently damage tissue, persist for at least a week post-injury at and extending away from the injury site in a large animal model.

6 Nov 2017

Researchers discover how traffic jam in intracellular sorting can cause tumor development

For tissues to cooperate and perform normal functions, cells need to know which way is up. When cells lose track of their orientation, they can start to grow out of control, and develop into cancer.

6 Nov 2017

Quorum sensing data presented at the North American Cystic Fibrosis Conference by Neem Biotech

Neem Biotech, the Welsh-based fundamental Research and Development arm of the Zaluvida group of life science companies, was pleased to present the work into development of a novel mode of action as an adjunct to existing antibiotics at the North American Cystic Fibrosis Conference Indiana, USA from 2nd November 2017 to 4th of November 2017.

From Neem Biotech 6 Nov 2017

Preclinical studies show effectiveness of targeted therapy for glioblastoma

The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

2 Nov 2017

First-of-its-kind nonsynthetic, decellularized graft one step closer to clinical trials

Researchers at the University of Minnesota have created a new lab-grown blood vessel replacement that is composed completely of biological materials, but surprisingly doesn't contain any living cells at implantation. The vessel, that could be used as an "off the shelf" graft for kidney dialysis patients, performed well in a recent study with nonhuman primates.

1 Nov 2017

Scientists identify treatments that may restore brain function to autism patients

Scientists have identified a pair of treatments that may restore brain function to autism patients who lack a gene critical to maintaining connections between neurons, according to a study from the Peter O'Donnell Jr. Brain Institute at UT Southwestern Medical Center.

1 Nov 2017

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

Starving a childhood brain tumor of the amino acid glutamine could improve the effect of chemotherapy, according to an early study led by Queen Mary University of London and funded by Children with Cancer UK and the Medical Research Council.

1 Nov 2017

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

The Global Health Innovative Technology Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection.

31 Oct 2017

Artificial beta cells could be first step to new treatment for diabetes

Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion.

30 Oct 2017

Longevity Biotech receives award to evaluate novel drug candidate for MS in preclinical models

Longevity Biotech, Inc. has received an award from the National Multiple Sclerosis Society through Fast Forward, the Society's commercial research funding program, to evaluate LBT-3627 in preclinical models as a potential disease-modifying therapeutic agent.

28 Oct 2017

Novel consortium aims to create new paradigm of cancer drug discovery

Scientists from two U.S. national laboratories, industry and academia today launched an unprecedented effort to transform the way cancer drugs are discovered by creating an open and sharable platform that integrates high-performance computing, shared biological data from public and industry sources and emerging biotechnologies to dramatically accelerate the discovery of effective cancer therapies.

27 Oct 2017

Preclinical News and Research

Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Study identifies promising treatment to reduce brain injury in babies

OSA may put elderly people at increased risk of developing Alzheimer's disease

Aspect Imaging announces receipt of CE marking for neonatal-dedicated MRI system

New gene therapy trial for X-linked myotubular myopathy offers hope to children

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Researchers identify new neuroprotective factor that holds potential to help people with glaucoma

Study shows hemodynamic and metabolic changes up to 7 days after traumatic spinal cord injury

Researchers discover how traffic jam in intracellular sorting can cause tumor development

Quorum sensing data presented at the North American Cystic Fibrosis Conference by Neem Biotech

Preclinical studies show effectiveness of targeted therapy for glioblastoma

First-of-its-kind nonsynthetic, decellularized graft one step closer to clinical trials

Scientists identify treatments that may restore brain function to autism patients

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

Artificial beta cells could be first step to new treatment for diabetes

Longevity Biotech receives award to evaluate novel drug candidate for MS in preclinical models

Novel consortium aims to create new paradigm of cancer drug discovery

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

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Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics