Hormone News and Research

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A hormone is a chemical released by one or more cells that affects cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. It is essentially a chemical messenger that transports a signal from one cell to another.

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

Pfizer Inc. today announced detailed overall survival data from the PALOMA-3 trial, which evaluated IBRANCE (palbociclib) in combination with fulvestrant compared to placebo plus fulvestrant in women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer whose disease progressed on or after prior endocrine therapy.

22 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating KEYTRUDA, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ or CIS plus papillary disease (Cohort A).

22 Oct 2018

Prostate radiotherapy improves survival in men with low burden of metastatic disease

Radiotherapy to the prostate improves overall survival in men newly diagnosed with metastatic prostate cancer who have a low metastatic disease burden but not in those with higher burden of disease, according to results from a pre-planned analysis of a large comparison study reported at ESMO 2018.

22 Oct 2018

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

Immunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.

22 Oct 2018

Phase III trial reports positive results with HDAC inhibitor in advanced breast cancer patients

Epigenetic therapy with histone deacetylase inhibitors is worth pursuing in hormone receptor positive advanced breast cancer, suggests a phase III trial reported today at the ESMO 2018 Congress in Munich.

22 Oct 2018

Zoledronic acid increases disease-free survival in premenopausal women with HR+ early breast cancer

Adjuvant treatment with the bone sparing drug zoledronic acid plus hormonal therapy with the aromatase inhibitor letrozole significantly increases disease-free survival compared to tamoxifen in premenopausal women with hormone receptor positive (HR+) early breast cancer, according to results reported at ESMO 2018 Congress in Munich.

22 Oct 2018

Breast cancer survival could be extended with two new drug combinations

A new study has shown that a combination of drugs palbociclib, along with hormone therapy can significantly increase the survival among women with advanced breast cancer.

21 Oct 2018

Radiotherapy can prolong survival in prostate cancer

A new major study from London has shown that radiotherapy can extend survival among patients with prostate cancer. The study shows that larger number of patients given standard therapy along with radiation therapy survived three years after the initiation of the study despite having a local spread of their cancer.

21 Oct 2018

Weight loss success associated with brain areas involved in self-control

New research suggests that higher-level brain functions have a major role in losing weight. In a study among 24 participants at a weight-loss clinic, those who achieved greatest success in terms of weight loss demonstrated more activity in the brain regions of the lateral prefrontal cortex associated with self-control.

19 Oct 2018

Skin-to-skin contact may promote attachment between parents and preterm infants

For premature infants in the neonatal intensive care unit, skin-to-skin contact with parents influences levels of hormones related to mother-infant attachment (oxytocin) and stress (cortisol) - and may increase parents' level of engagement with their infants, reports a study in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.

19 Oct 2018

Researchers investigate why some cancers affect only young women

Among several forms of pancreatic cancer, one of them affects specifically women, often young. How is this possible, even though the pancreas is an organ with little exposure to sex hormones? This pancreatic cancer, known as "mucinous cyst", has strange similarities with another mucinous cancer, affecting the ovaries.

19 Oct 2018

New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women

A statistical method could fill the gaps in the U.S. cancer registry data to estimate the short- and long-term risk of recurrence of hormone receptor (HR)-positive and HR-negative breast cancers.

19 Oct 2018

High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients

Nearly one in six premenopausal women being treated for early stage breast cancer do not adhere adequately to tamoxifen therapy after one year of treatment, potentially putting themselves at increased risk of recurrence and reduced survival, a French prospective study reports at ESMO 2018.

19 Oct 2018

Finger length can predict sexuality in women say researchers

Researchers from the Psychology department of Essex University have made claims that take us back to medieval ages of palmistry and predictions but could have a biological basis.

19 Oct 2018

A new approach identified to control Zika virus, dengue fever

Mosquitoes are the world's deadliest animals, killing thousands of people and causing millions of illnesses each year.

19 Oct 2018

Study finds undiagnosed prediabetes in many infertile men

In a study of 744 infertile men, prediabetes was found in 114 (15.4 percent) of participants. Certain factors were linked with prediabetes in the BJU International study, and they might be useful markers for identifying men who could benefit from early preventive interventions to safeguard against the development of diabetes.

17 Oct 2018

Age-related estrogen increase may be the culprit behind inguinal hernias in men

An age-related increase in estrogen may be the culprit behind inguinal hernias, a condition common among elderly men that often requires corrective surgery, according to a Northwestern Medicine study was published Oct. 15 in Proceedings of the National Academy of Sciences.

16 Oct 2018

Males who spend more time taking care of kids have greater reproductive success

Males have greater reproductive success if they spend more time taking care of kids -- and not necessarily only their own, according to new research published by anthropologists at Northwestern University.

15 Oct 2018

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

Mice with epilepsy have altered patterns of neuron activity in the portion of the brain that controls the reproductive endocrine system, University of Illinois researchers report in a new study. Furthermore, the differences in neuron activity in female mice fluctuate across the reproductive cycle, the team found.

15 Oct 2018

Hormone News and Research

Further Reading

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Prostate radiotherapy improves survival in men with low burden of metastatic disease

Immunotherapy increases survival in some patients with metastatic triple negative breast cancer

Phase III trial reports positive results with HDAC inhibitor in advanced breast cancer patients

Zoledronic acid increases disease-free survival in premenopausal women with HR+ early breast cancer

Breast cancer survival could be extended with two new drug combinations

Radiotherapy can prolong survival in prostate cancer

Weight loss success associated with brain areas involved in self-control

Skin-to-skin contact may promote attachment between parents and preterm infants

Researchers investigate why some cancers affect only young women

New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women

High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients

Finger length can predict sexuality in women say researchers

A new approach identified to control Zika virus, dengue fever

Study finds undiagnosed prediabetes in many infertile men

Age-related estrogen increase may be the culprit behind inguinal hernias in men

Males who spend more time taking care of kids have greater reproductive success

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

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