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A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis

Marked by chronic inflammation of the joints and tissue, rheumatoid arthritis (RA) is a painful and potentially disabling autoimmune disease.

30 Jan 2007

New type of buckyball

Scientists at Rice University and Baylor College of Medicine have developed a new type of buckyball nanoparticle that acts as a passkey, allowing peptide-based drugs to enter cancer cells.

29 Jan 2007

Molecular mechanism behind aggregation of amyloid beta peptide due to anesthetics

Inhaled anesthetics commonly used in surgery are more likely to cause the aggregation of Alzheimer's disease-related plaques in the brain than intravenous anesthetics say University of Pittsburgh School of Medicine researchers in a journal article published in Biochemistry.

28 Jan 2007

Melanin concentrating hormone found to be involved with insulin production

A new Joslin Diabetes Center-led study has shown conclusively that a neuropeptide, melanin concentrating hormone (MCH), found in the brain and known for its role in increasing appetite in people, plays a role in the growth of insulin-producing beta cells and the secretion of insulin.

28 Jan 2007

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Researchers at Montana State University have used an engineered form of ferritin, a cage-like iron storage protein, to both synthesize and deliver iron oxide nanoparticles to tumors.

16 Jan 2007

Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Fibrinogen molecule structure acts as a molecular spring

Researchers at the University of Pennsylvania School of Medicine and the School of Arts and Sciences have shown that a well-known protein structure acts as a molecular spring, explaining one way that clots may stretch and bend under such physical stresses as blood flow.

14 Jan 2007

Simple blood test for NT-proBNP level may help predict cardiovascular events

A blood test for patients with coronary heart disease could help predict their risk for subsequent cardiovascular events or death, according to a study in the January 10 issue of JAMA: The Journal of the American Medical Association.

9 Jan 2007

Viral Genetics identifies two key peptides for potential HIV/AIDS drug

Viral Genetics has identified two key peptides involved in its thymus nuclear protein or "TNP" technology currently under development for the treatment of HIV/AIDS.

9 Jan 2007

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

In the first experiment of its kind, investigators at the Center for Cancer Nanotechnology Excellence Focused on Therapy Response (CCNE-TR), based at Stanford University, have shown that single-walled carbon nanotubes (SWCNTs) wrapped in poly(ethylene glycol), or PEG, can successfully target tumors in living animals.

8 Jan 2007

NanoMed Pharmaceuticals issued new U.S. nanoparticle patent

NanoMed Pharmaceuticals has announced that founders Russell J. Mumper, Ph.D. and Michael Jay, Ph.D. have been issued U.S. Patent 7,153,525 entitled "Microemulsions As Precursors To Solid Nanoparticles."

3 Jan 2007

Stem cells grown into brain cells on a new 3D scaffold of tiny protein fragments

An MIT engineer and Italian colleagues will report the invention-which may one day replace the ubiquitous Petri dish for growing cells-in PLoS ONE.

2 Jan 2007

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Combining two promising approaches to diagnosing and treating cancer, a multidisciplinary research team at the University of Michigan has created a targeted multifunctional polymer nanoparticle that successfully images and kills brain tumors in laboratory animals.

4 Dec 2006

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

In attempt to identify biological markers, or biomarkers, that can signal the presence of cancer and help oncologists determine the best course of therapy when cancer is present, teams of investigators are scouring stored tissue samples obtained from thousands of cancer patients.

4 Dec 2006

Cytogen issued new patent covering oral drug delivery agents

Cytogen Corporation has announced that it has been issued United States patent number 7,135,457 covering its oral drug delivery agents - random peptide compositions that bind to gastro-intestinal tract (GIT) transport receptors.

28 Nov 2006

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

Quantum dots are rapidly becoming biomedical researchers' tool of choice for adding a fluorescent label to a wide variety of biomolecules.

20 Nov 2006

Yeast model system may provide a means for treating the earliest stage of Alzheimer's

A century ago this month, German psychiatrist Alois Alzheimer formally described characteristics of the neurodegenerative disease which ultimately came to bear his name. While international efforts to learn about Alzheimer's disease and develop treatments have progressed significantly in recent years, a cure remains an elusive goal.

19 Nov 2006

Weill Cornell findings could foil two potential bioterror agents - viral peptide prevents deadly Hendra, Nipah viruses from infecting cells

Two lethal and easily transmitted viruses -- both potential bioterror agents -- may soon be much less dangerous, thanks to research led by scientists at Weill Cornell Medical College in New York City.

31 Oct 2006

Twisted molecule, large and folded like a protein - but completely synthetic

The physiological functions of proteins depend on their folding into a particular spatial structure (tertiary structure): enzymes and their substrates must fit together like the proverbial lock and key.

26 Oct 2006

Researchers identify peptide that spurs cargo transport in nerve cells

For the first time, researchers have identified a peptide that can spur cargo transport in nerve cells, a discovery that could help scientists better understand nerve cell function and test possible therapies for neurodegenerative diseases.

24 Oct 2006