Preclinical News and Research

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New version of gene editing technique corrects molecular mistakes in RNA-based diseases

Until recently, the CRISPR-Cas9 gene editing technique could only be used to manipulate DNA. In a 2016 study, University of California San Diego School of Medicine researchers repurposed the technique to track RNA in live cells in a method called RNA-targeting Cas9 (RCas9).

11 Aug 2017

Small clinical trial shows promise for treating rare neurodegenerative disease

Results of a small clinical trial show promise for treating a rare neurodegenerative condition that typically kills those afflicted before they reach age 20.

11 Aug 2017

UAB researchers create small molecule that prevents tooth cavities in preclinical model

University of Alabama at Birmingham researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model.

10 Aug 2017

New discovery provides insights into how the tongue preserves its sense of taste

New research at Columbia University Medical Center has revealed how special molecules help the tongue communicate with the brain to identify the correct taste.

10 Aug 2017

Human gut microbe may help treat autoimmune diseases, say researchers

Mayo Clinic researchers, along with colleagues at the University of Iowa, report that a human gut microbe discovered at Mayo Clinic may help treat autoimmune diseases, such as multiple sclerosis. The findings appear in Cell Reports.

8 Aug 2017

Researchers demonstrate potential of new PET tracer for imaging prostate cancer

In the featured translational article in the August issue of The Journal of Nuclear Medicine, researchers at the University of Michigan demonstrate the potential of a new PET tracer, Carbon-11 labeled sarcosine (11C-sarcosine), for imaging prostate cancer, and set the stage for its possible use in monitoring other cancers.

7 Aug 2017

New clinical trial examines potential role of drug combination therapy to eliminate LAM cells

Researchers at the University of Cincinnati begin a new clinical trial this fall, examining the potential role of a drug combination therapy to eliminate lymphangioleiomyomatosis (LAM) cells.

7 Aug 2017

Omeros’ OMS721 receives orphan drug designation from FDA for treatment of IgA nephropathy

Omeros Corporation today announced that OMS721 has received orphan drug designation from the U.S. Food and Drug Administration for the treatment of Immunoglobulin A (IgA) nephropathy.

4 Aug 2017

Biologic substance APOSEC shows promise for healing dermal wounds

APOSEC is a substance obtained from white blood corpuscles and was developed by a research group led by thoracic surgeon Hendrik Jan Ankersmit, Head of the Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration at MedUni Vienna.

3 Aug 2017

Researchers ferreting out patients most likely to become resistant to cancer treatment

According to the National Cancer Institute, the number of people beating a cancer diagnosis reached nearly 14.5 million in 2014 and is expected to rise to almost 19 million by 2024. Now, that's good news, but it doesn't mean that cancer researchers - in the lab or clinic - are resting on any laurels.

2 Aug 2017

Researchers develop ceramic skull implant to deliver ultrasound treatments through thick skulls

Ultrasound brain surgery has enormous potential for the treatment of neurological diseases and cancers, but getting sound waves through the skull and into the brain is no easy task.

2 Aug 2017

Takeda and Cardurion announce creation of new cardiovascular development partnership

Takeda Pharmaceutical Company Limited and Cardurion Pharmaceuticals today announced the creation of a new cardiovascular development partnership.

2 Aug 2017

MR Solutions’ dry magnet system provides high resolution imaging within compact footprint

When it comes to choosing a preclinical MRI imaging system there is no need to compromise – MR Solutions’ 9.4T cryogen free, or dry magnet system provides state of the art high resolution imaging within a compact footprint.

2 Aug 2017

Expert highlights CRISPR’s applications, limitations, and ethical concerns

"Good morning, doctor, I am here for my gene editing appointment." In the future, could this be a greeting heard in physician offices around the world? With the introduction of CRISPR technology, genetic material can now be more easily and precisely edited, even creating changes that can subsequently be inherited by offspring.

1 Aug 2017

Preclinical News and Research

New version of gene editing technique corrects molecular mistakes in RNA-based diseases

Small clinical trial shows promise for treating rare neurodegenerative disease

UAB researchers create small molecule that prevents tooth cavities in preclinical model

New discovery provides insights into how the tongue preserves its sense of taste

Human gut microbe may help treat autoimmune diseases, say researchers

Researchers demonstrate potential of new PET tracer for imaging prostate cancer

New clinical trial examines potential role of drug combination therapy to eliminate LAM cells

Omeros’ OMS721 receives orphan drug designation from FDA for treatment of IgA nephropathy

Biologic substance APOSEC shows promise for healing dermal wounds

Researchers ferreting out patients most likely to become resistant to cancer treatment

Researchers develop ceramic skull implant to deliver ultrasound treatments through thick skulls

Takeda and Cardurion announce creation of new cardiovascular development partnership

MR Solutions’ dry magnet system provides high resolution imaging within compact footprint

Expert highlights CRISPR’s applications, limitations, and ethical concerns

Novel imaging tracer can help assess patient’s rupture risk for abdominal aortic aneurysm

New drug may limit disease progression, provide better symptom relief to Parkinson's patients

Experiments in big animals show efficacy of new non-toxic MRI contrast agent

Juvenescence AI to develop first compounds generated by Insilico's deep-learned drug discovery engines

Stem cell-based method selectively targets cancerous tissue while preventing toxic side effects

Researchers discover potential chemical 'silver bullet' to reduce risk of colon cancer

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Evaluating new approaches for rare disease genomics