Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

PAM50 FDA-cleared breast cancer test to be launched at ARUP Laboratories

The PAM50 breast cancer signature developed at the University of Utah and Huntsman Cancer Institute received FDA approval and will launch at ARUP Laboratories in Salt Lake City. The test utilizes gene expression data from 50 genes weighted together with clinical variables to generate a risk category and numerical score to assess a patient's risk of distant recurrence at ten years in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), Hormone Receptor-Positive (HR+) breast cancer.

16 Dec 2013

Study could lead towards a personalised medicine for chemoresistant lymphomata

To date, tests have only been carried out on cells, but a piece of research conducted by the Department of Genetics at the UPV/EHU's Faculty of Medicine in collaboration with MD Anderson and the CNIO is opening up the door for the treatment of lymphoma types that have a lower survival rate. The study of the molecular characteristics of the tumours would enable molecules that are altered in a specific way to be identified and turned into new therapeutic targets that would improve the prognosis of patients with chemoresistant lymphomata.

16 Dec 2013

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

The Genetics Society of America (GSA) is pleased to announce the selection of eleven early career researchers - five graduate students and six postdoctoral researchers - as recipients of a spring 2014 DeLill Nasser Award for Professional Development in Genetics.

15 Dec 2013

Study shows effectiveness of PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced new results from a combined analysis of the Austrian Breast & Colorectal Cancer Study Group 8 (ABCSG-8) and Trans-Arimidex, Tamoxifen, Alone or in Combination (TransATAC) studies. These results, which evaluated samples from 2,137 patients, suggest that the PAM50-based Prosignaz Breast Cancer Prognostic Gene Signature Assay may help identify women with late distant recurrence after five years of endocrine treatment.

13 Dec 2013

Spaceflights cause cellular-level damage and may lead to long-term vision problems

Those who travel to space are rewarded with a beautiful sight - planet Earth. But the effects of space travel on the human sense of sight aren't so beautiful. More than 30 percent of astronauts who returned from two-week space shuttle missions and 60 percent who spent six months aboard the International Space Station were diagnosed with eye problems. Two recent investigations examined mechanisms that may explain eye changes in spaceflight, help find ways to minimize this health risk to astronauts and eventually prevent and treat eye diseases on Earth.

13 Dec 2013

Gene Expression Barcode 3.0 tool proves to be a vital resource for cancer research

A newly improved internet research tool is helping cancer researchers and physicians make sense out of a deluge of genetic data from nearly 100,000 patients and more than 50,000 mice.

13 Dec 2013

Combination therapy safe and active in follicular lymphoma

One drug attacks tumor cells directly, the other treats the immune system by taking the brakes off T cell response.

12 Dec 2013

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

It is well known that type 2 diabetes raises the risk of dementia. The reasons for this are less clear, but one explanation could be insulin resistance in the brain, according to Malin Wennstr-m, a researcher at Lund University's Molecular Memory Research Unit. She has received EUR 700,000 from the Swedish Research Council to investigate her theory.

12 Dec 2013

Tumor-infiltrating lymphocytes may be good biomarker of response to trastuzumab in breast cancer

Women with HER2-positive breast cancer who had the highest levels of immune cells in their tumors gained the most benefit from presurgery treatment with chemotherapy and trastuzumab, according to results presented here at the 2013 San Antonio Breast Cancer Symposium, held Dec. 10-14.

12 Dec 2013

Scientists use new method to map response of every salmonella gene to conditions in human body

Scientists have used a new method to map the response of every salmonella gene to conditions in the human body, providing new insight into how the bacteria triggers infection.

12 Dec 2013

Nanostring Technologies announces nationwide availability of Prosigna Breast Cancer Assay in 2014

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced nationwide availability of the Prosigna™ Breast Cancer Prognostic Gene Signature Assay beginning in the first quarter of 2014.

From NanoString Technologies 11 Dec 2013

UC Santa Barbara professor finds method for measuring cellular forces that shape tissues, organs

Like tiny construction workers, cells sculpt embryonic tissues and organs in 3D space. This task is complicated and requires constant communication between cells to coordinate their actions and generate the forces that will shape their environment into complex tissue morphologies.

10 Dec 2013

Research explores epigenetic effects that contribute to psychiatric disorders in offspring

Advanced paternal age has been associated with greater risk for psychiatric disorders, such as schizophrenia and autism. With an increase in paternal age, there is a greater frequency of certain types of mutations that contribute to these disorders in offspring.

9 Dec 2013

New study reports first evidence of specific molecular changes in the body with meditation

With evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.

6 Dec 2013

Innovative DNA engineering technique discovers potential functions hidden within bacterial genomes

A group of University of Illinois researchers, led by Centennial Chair Professor of the Department of Chemical and Biomolecular Engineering Huimin Zhao, has demonstrated the use of an innovative DNA engineering technique to discover potentially valuable functions hidden within bacterial genomes.

6 Dec 2013

Molecular mechanisms of NR2B regulates age-related memory storage, brain aging

The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment.

6 Dec 2013

New program to investigate link between secondhand smoke and ADHD in children

Duke Medicine has established a new research program to investigate the relationship between exposure to environmental tobacco smoke during pregnancy and childhood and attention deficit hyperactivity disorder (ADHD) in children.

6 Dec 2013

Researchers take closer look at genetically engineered mouse models and human cancer samples

Researchers from the Fred Hutchinson Cancer Research Center in Seattle, WA have taken a closer look at existing mouse models of cancer, specifically comparing them to human cancer samples. These genetically engineered mouse models (which usually either overexpress a cancer-causing gene-or "oncogene"-or carry a deletion for a "tumor suppressor" gene) have been extensively used to understand human cancer biology in studies of drug resistance, early detection, metastasis, and cancer prevention, as well as for the preclinical development of novel targeted therapeutics.

6 Dec 2013

Research: Low level of daily exposure to sunlight can cause skin damage

A low level of daily exposure to a common component of sunlight can cause skin damage at the molecular level after just a few days, new University of Michigan Medical School research shows.

5 Dec 2013

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

A new paper published in Biological Psychiatry suggests that cognitive behavioral therapy for posttraumatic stress disorder not only reduces symptoms but also affects the underlying biology of this disorder.

4 Dec 2013

Gene Expression News and Research

Further Reading

PAM50 FDA-cleared breast cancer test to be launched at ARUP Laboratories

Study could lead towards a personalised medicine for chemoresistant lymphomata

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

Study shows effectiveness of PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay

Spaceflights cause cellular-level damage and may lead to long-term vision problems

Gene Expression Barcode 3.0 tool proves to be a vital resource for cancer research

Combination therapy safe and active in follicular lymphoma

Lund University researcher explores why type 2 diabetes raises dementia risk later in life

Tumor-infiltrating lymphocytes may be good biomarker of response to trastuzumab in breast cancer

Scientists use new method to map response of every salmonella gene to conditions in human body

Nanostring Technologies announces nationwide availability of Prosigna Breast Cancer Assay in 2014

UC Santa Barbara professor finds method for measuring cellular forces that shape tissues, organs

Research explores epigenetic effects that contribute to psychiatric disorders in offspring

New study reports first evidence of specific molecular changes in the body with meditation

Innovative DNA engineering technique discovers potential functions hidden within bacterial genomes

Molecular mechanisms of NR2B regulates age-related memory storage, brain aging

New program to investigate link between secondhand smoke and ADHD in children

Researchers take closer look at genetically engineered mouse models and human cancer samples

Research: Low level of daily exposure to sunlight can cause skin damage

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

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