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Several hepatitis C drugs can inhibit crucial protein in SARS-CoV-2

Experiments led by researchers at the Department of Energy's Oak Ridge National Laboratory have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.

17 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence could lead to new class of drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

Targeting BCAP with new drugs could benefit people with inflammatory bowel disease

Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new study led by experts at Cincinnati Children's.

17 Nov 2020

Nanobodies: unharnessed potential in COVID-19 treatment

A new study published in the Journal of Biomolecular Structure and Dynamics in October 2020 discusses the use of nanobodies in diagnosing and treating this deadly disease.

16 Nov 2020

Metabolic biomarkers could predict COVID-19 severity

A new study suggests that metabolic biomarkers could possibly predict the severity of COVID-19 in patients.

16 Nov 2020

New antibody fragment helps reduce Aβ levels in old mice with Alzheimer’s disease

Alzheimer's disease is the most common dementia worldwide and it is characterized by learning impairment, memory loss, disorientation, and anxiety, among other behavioral and psychological symptoms.

16 Nov 2020

Research provides insight into how Alzheimer’s plaques form

We are beginning to better understand how 'amyloid-β' protein plaques form, which are implicated in degenerative brain diseases including Alzheimer's and Parkinson's diseases.

16 Nov 2020

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

De'Broski Herbert has a philosophy that's guided his career researching helminths, or parasitic worms, and their interaction with their hosts' immune systems: "Follow the worm."

15 Nov 2020

Promising MS drug may make the debilitating disease worse

A drug that has shown promise for treating multiple sclerosis may actually make the debilitating disease worse, new research from the University of Virginia School of Medicine suggests.

15 Nov 2020

Harnessing proteomics could improve therapeutic approaches to COVID-19

A research group in India has recently described how the field of proteomics could be pivotal in helping to tackle the current coronavirus disease 2019 (COVID-19) pandemic.

15 Nov 2020

Neuroscientists identify astrocytes as master 'conductors' of the brain

In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.

12 Nov 2020

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – has already infected over 52 million people worldwide, and has subsequently claimed over 1.3 million lives. However, among the innumerable promising drug candidates that help battle the virus and mitigate its damage, none have yet made it to the clinic.

12 Nov 2020

Imaging technique reveals opioid receptor localization across the whole brain

Winding and twisting like a labyrinth, the brain consists of an elaborate network of passages through which information flows at high speeds, rapidly generating thoughts, emotions, and physical responses.

12 Nov 2020

Men and women may require different brain tumor therapy, study finds

The current study shows that the sex differences in the tumor phenotype vary with the effect of the enhancer regulatory molecule bound to Brd4 on the course of stem cell-like differentiation in male and female GBM cells. Inhibition of Brd4 by genetic and pharmacological factors also varies in males and females, both in vivo and in vitro.

11 Nov 2020

MD Anderson presents positive clinical data from combination cancer therapies at SITC 2020

Promising clinical results with combination treatments for patients with melanoma and lung cancer highlight immunotherapy advances being presented by researchers from The University of Texas MD Anderson Cancer Center at The Society for Immunotherapy of Cancer 35th Anniversary Annual Meeting & Pre-Conference Programs.

11 Nov 2020

IU researcher awarded NCI grant to develop a drug for making radiation therapy more effective

An Indiana University Melvin and Bren Simon Comprehensive Cancer Center researcher has been awarded a five-year, $2.9 million grant from the National Cancer Institute to develop a drug that could make radiation therapy far more effective.

11 Nov 2020

Study: Effect of diabetes medication can be blocked by a molecule from gut bacteria

The action of metformin, the classic drug used to treat diabetes by stabilizing blood sugar, can be blocked by a molecule from the bacteria in our intestines, a University of Gothenburg study shows.

11 Nov 2020

Synthetic protein nanoparticle may treat aggressive brain cancer

A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

11 Nov 2020

“Molecular volume knob” in the brain helps with learning, memory

A "molecular volume knob" regulating electrical signals in the brain helps with learning and memory, according to a Dartmouth study.

11 Nov 2020

A promising vaccine for treating poorly immunogenic tumors

Patients with cancer have multiple treatment options available to them today, but each has its drawbacks. Chemotherapy kills rapidly dividing cancer cells, but it also damages healthy cells in the body and often does not effectively prevent tumor metastasis or disease recurrence.

11 Nov 2020

Molecule News and Research

Several hepatitis C drugs can inhibit crucial protein in SARS-CoV-2

Discovery of 'Achilles heel' in protein crucial to HIV virulence could lead to new class of drugs

Targeting BCAP with new drugs could benefit people with inflammatory bowel disease

Nanobodies: unharnessed potential in COVID-19 treatment

Metabolic biomarkers could predict COVID-19 severity

New antibody fragment helps reduce Aβ levels in old mice with Alzheimer’s disease

Research provides insight into how Alzheimer’s plaques form

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

Promising MS drug may make the debilitating disease worse

Harnessing proteomics could improve therapeutic approaches to COVID-19

Neuroscientists identify astrocytes as master 'conductors' of the brain

Peptide-conjugated morpholino oligomers effectively inhibit SARS-CoV-2 in vero cells

Imaging technique reveals opioid receptor localization across the whole brain

Men and women may require different brain tumor therapy, study finds

MD Anderson presents positive clinical data from combination cancer therapies at SITC 2020

IU researcher awarded NCI grant to develop a drug for making radiation therapy more effective

Study: Effect of diabetes medication can be blocked by a molecule from gut bacteria

Synthetic protein nanoparticle may treat aggressive brain cancer

“Molecular volume knob” in the brain helps with learning, memory

A promising vaccine for treating poorly immunogenic tumors

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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