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Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

Researchers develop extraction-free saliva RT-LAMP assay for workplace surveillance of SARS-CoV-2

Researchers developed a saliva-based, extraction-free reverse transcription loop-mediated isothermal amplification workflow for SARS-CoV-2 detection.

17 Mar 2022

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Researchers evaluate the feasibility of tonsil epithelial cell-derived organoids as an ex vivo model for studying SARS-CoV-2 infection.

15 Mar 2022

Sustainable material-based biosensors for SARS-CoV-2 detection

Researchers conducted a brief review on biosensors based on sustainable materials for SARS-CoV-2 detection.

15 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Intersectional, anterograde transsynaptic targeting system used to reveal two different brain circuits

Osaka Metropolitan University uses new “intersectional, anterograde transsynaptic targeting system” to reveal two different mouse brain circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum.

8 Mar 2022

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

In a recent study posted to the medRxiv*preprint server, a team of researchers from Israel developed and validated novel reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR) assays. The new assays enable the rapid and high throughput identification and differentiation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.1 and BA.2 variants.

8 Mar 2022

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Researchers discovered compounds able to inhibit SARS-CoV-2 macrodomain 1 and adenosine diphosphate-ribose binding via high throughput screening.

7 Mar 2022

Canopy Biosciences launches next-generation ChipCytometry™ instrument for spatial biology with sub-cellular resolution

Canopy Biosciences, a Bruker Company, today announced the commercial launch of the CellScape™ system, the next generation in ChipCytometry™ instrumentation, advancing the cutting-edge for quantitative in situ spatial phenotyping.

From Bruker Nano Surfaces and Metrology 7 Mar 2022

New fluorescent label provides a clearer picture of how DNA architecture is disrupted in cancer cells

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients and classification of future cancer risk.

4 Mar 2022

Researchers design a peptide hydrogel for cell spheroids production

This study is led by Prof. Zhimou Yang and Prof. Quan Chen (College of Life Sciences in Nankai University), and Prof. Jianfeng Liu (Institute of Radiation Medicine, Chinese Academy of Medical Sciences). Prof. Zhimou Yang, who is working in the research field of peptide self-assembly biomaterials for more than 15 years, designed the peptide hydrogel for cell spheroids production.

4 Mar 2022

Fluorescence News and Research

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers develop extraction-free saliva RT-LAMP assay for workplace surveillance of SARS-CoV-2

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Sustainable material-based biosensors for SARS-CoV-2 detection

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

CRIPSR identifies cell-type-specific ACE2 modifiers

Intersectional, anterograde transsynaptic targeting system used to reveal two different brain circuits

Development of RT-qPCR assays for differentiating SARS-CoV-2 Omicron BA.1 and BA.2 variants

Identification of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding

Canopy Biosciences launches next-generation ChipCytometry™ instrument for spatial biology with sub-cellular resolution

New fluorescent label provides a clearer picture of how DNA architecture is disrupted in cancer cells

Researchers design a peptide hydrogel for cell spheroids production

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

8G3 broad-spectrum antibody effective against all SARS-CoV-2 variants, including Omicron

DeNovix to give away Platinum Edition CellDrop™ Automated Cell Counter in celebration of prestigious award

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Mechanism behind how certain osmolytes cause kidney damage revealed

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

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