Metabolites News and Research

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Coffee’s hidden compounds could help fight type 2 diabetes

A comprehensive review of nearly 150 studies reveals that coffee polyphenols may help regulate blood sugar and reduce inflammation linked to type 2 diabetes. However, most evidence comes from preclinical research, and robust clinical trials are needed to confirm benefits.

29 Jun 2025

Pesticides found to disrupt specific gut bacteria linked to inflammation

While emerging evidence suggests pesticides can be toxic to the mix of microorganisms in the digestive system, a new study is the first to map changes to specific gut bacteria based on interactions between human microbes and insect-killing chemicals observed in the lab and an animal model.

27 Jun 2025

New insights into exercise physiology through enduromics and resistomics

Exercise has been recognized as an extremely effective tool to improve human health— it can have a preventative and even therapeutic effect on non-communicable diseases such as diabetes and cardiovascular diseases.

27 Jun 2025

Do spicy foods help or hurt your gut health?

Capsaicin, the spicy compound in chili peppers, not only influences inflammation, metabolism, and cancer risk but also shapes the gut microbiome in complex, context-dependent ways. This comprehensive review highlights both the therapeutic promise and potential risks of capsaicin, calling for deeper research into its microbiome-mediated effects.

26 Jun 2025

Missing gut bacteria in US babies triples allergy and eczema risk

US infants lacking Bifidobacterium in their gut microbiome face significant changes in microbial composition, metabolic function, and immune-related health risks. This large, nationally representative study links early-life Bifidobacterium deficits to a three-fold increase in eczema, allergy, or asthma by age two.

25 Jun 2025

Gut microbe emerges as a promising tool in the fight against COVID-19

Researchers found that Akkermansia muciniphila boosts lung-specific antiviral immunity against SARS-CoV-2 in mice by modulating the gut–lung axis. This commensal gut bacterium shows promise as a potential biomarker and biotherapeutic candidate for COVID-19 and other respiratory infections.

25 Jun 2025

New insights into the role of diet and microbiome in gastric cancer

Gastric cancer (GC), once primarily seen in older adults, is on the rise among younger individuals in developed countries.

25 Jun 2025

Is aspartame safe for blood sugar? Study answers the big question

A major systematic review and meta-analysis found that aspartame has little to no effect on blood glucose, insulin, or appetite-regulating hormones in humans. Evidence certainty is very low, with no significant long-term metabolic impact identified.

25 Jun 2025

New KRAS mutation discovery opens door to targeted colon cancer therapies

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene - a gene that can cause cancer - that may play an important role in colon cancer. Researchers also showed how this mutation could be targeted therapeutically.

24 Jun 2025

Probiotics remain potent in simple plant-based drinks

Non-encapsulated probiotics thrive in fruit and vegetable juices, maintaining viability and sensory appeal, paving the way for innovative functional beverages.

24 Jun 2025

Genes may determine how early life exposures shape the gut microbiome

Early nutritional and antibiotic exposures affect adult gut microbiota, with genetic background and parent-of-origin significantly influencing outcomes.

19 Jun 2025

CAR T-cell therapy successfully treats rare autoimmune disease of the peripheral nervous system

Physicians from Bochum have used a cancer treatment method to treat severe autoimmune diseases.

18 Jun 2025

Gut microbiome resists major changes from a nut-rich diet

The systematic review highlights that while nuts influence gut microbiota, the effects are modest and vary by nut type, warranting further investigation.

18 Jun 2025

Popular painkiller use linked to gut microbiome shifts

Estrogen-responsive cells found to heighten gut pain in females

Researchers uncovered how estrogen heightens gut sensitivity in females by activating PYY-secreting L-cells, which stimulate serotonin release from EC cells. This paracrine circuit intensifies pain signaling and may explain the sex bias in conditions like IBS.

16 Jun 2025

COVID-19 triggers metabolic signatures in kids that mirror adult heart risk

Children with acute COVID-19 and MIS-C show significant disruptions in lipid metabolism, including patterns resembling adult severe COVID-19. These findings highlight potential long-term cardiovascular risks in pediatric SARS-CoV-2 cases and underscore the need for follow-up care.

16 Jun 2025