Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Study identifies new mutations linked to hereditary neuroendocrine tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component. Half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle, a metabolic route involved in cellular respiration.

20 Jul 2017

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also have up to a 39 percent chance to develop ovarian cancer.

19 Jul 2017

Study provides insights into intergenerational inheritance of epigenetic information

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off.

18 Jul 2017

Mutations arising after conception may play vital role in autism

A study of nearly 6,000 families, combining three genetic sequencing technologies, finds that mutations that occur after conception play an important role in autism.

17 Jul 2017

ASU-TGen researchers find source of altered ANK1 gene expression linked to Alzheimer's disease

Researchers led by Arizona State University and the Translational Genomics Research Institute have identified altered expression of a gene called ANK1, which only recently has been associated with memory robbing Alzheimer's disease, in specific cells in the brain.

14 Jul 2017

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

The researchers from Harvard University, Seth L. Shipman, Jeff Nivala, Jeffrey D. Macklis and George M. Church, believe that their study is a major step forward to a "molecular recorder" that may someday make it possible to get read-outs, has published online their proof-of-concept on July 12, 2017, in the journal Nature.

14 Jul 2017

Experts develop first freely available data network for Huntington's disease research

Huntington's disease is a hereditary disorder of the nervous system caused by a faulty gene on chromosome four.

13 Jul 2017

Computational analysis of open-access data points to new ways of using drugs

A research team led by scientists at UC San Francisco has developed a computational method to systematically probe massive amounts of open-access data to discover new ways to use drugs, including some that have already been approved for other uses.

12 Jul 2017

Scientists find single protein that controls genes essential for spermatogenesis

Scientists have found a single protein--Ptbp2--controls a network of over 200 genes central to how developing sperm move and communicate. The protein works by regulating how RNA is processed during each stage of sperm development.

10 Jul 2017

Maternal consumption of alcohol could produce transgenerational effects

Soon-to-be mothers have heard the warning - don't drink while pregnant. The Centers for Disease Control and Prevention has issued numerous statements about the dangers of alcohol consumption during pregnancy, as it can lead to Fetal Alcohol Spectrum Disorders (FASD) in newborns.

7 Jul 2017

Lower calorie intake by host may increase chances of surviving malaria

The chances of surviving a malaria infection may be higher when the host consumes fewer calories, according to new research.

6 Jul 2017

Corticosteroids may worsen disease in some patients with severe asthma

Researchers from the University of Pittsburgh Schools of the Health Sciences and UPMC have uncovered the molecular mechanism underlying corticosteroid resistance in severe asthma.

6 Jul 2017

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

After 12 weeks of taking an anti-asthma drug, a subset of patients with type 2 diabetes showed a clinically significant reduction in blood glucose during a randomized, double blind, placebo-controlled clinical trial, report University of California San Diego School of Medicine and University of Michigan researchers.

5 Jul 2017

Research underscores how environments during infancy can cause inflammation in adulthood

New Northwestern University research underscores how environmental conditions early in development can cause inflammation in adulthood - an important risk factor for a wide range of diseases of aging, including cardiovascular diseases, diabetes, autoimmune diseases and dementia.

4 Jul 2017

Beta blockers reverse potentially detrimental genetic changes linked to heart disease

Beta blockers are commonly used world-wide to treat a variety of cardiovascular conditions, such as arrhythmias and heart failure.

30 Jun 2017

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

By comparing variations in protein expression in tumor samples from a single melanoma patient, researchers from the Johns Hopkins Bloomberg~Kimmel Institute and the Memorial Sloan-Kettering Cancer Center say their findings have the potential to reveal some of the mechanisms underlying response or resistance to immunotherapy drugs.

28 Jun 2017

Engineers take closer look at mechanical and chemical attributes of heart defect

Elastin and collagen serve as the body's building blocks. They provide tensile strength and elasticity for a number of organs, muscles and tissues. Any genetic mutation short-circuiting their function can have a devastating, and often lethal, health impact.

28 Jun 2017

Mouse brain models reveal insights into genetics of autism

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels of disability.

28 Jun 2017

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Tiny biological nanoparticles offer enormous potential for diagnostic and therapeutic applications

Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded.

23 Jun 2017

Gene Expression News and Research

Further Reading

Study identifies new mutations linked to hereditary neuroendocrine tumors

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

Study provides insights into intergenerational inheritance of epigenetic information

Mutations arising after conception may play vital role in autism

ASU-TGen researchers find source of altered ANK1 gene expression linked to Alzheimer's disease

CRISPR technology shows potential as a “molecular recorder” through DNA encoded movie

Experts develop first freely available data network for Huntington's disease research

Computational analysis of open-access data points to new ways of using drugs

Scientists find single protein that controls genes essential for spermatogenesis

Maternal consumption of alcohol could produce transgenerational effects

Lower calorie intake by host may increase chances of surviving malaria

Corticosteroids may worsen disease in some patients with severe asthma

Anti-asthma drug shows blood glucose improvement among some patients with type 2 diabetes

Research underscores how environments during infancy can cause inflammation in adulthood

Beta blockers reverse potentially detrimental genetic changes linked to heart disease

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

Engineers take closer look at mechanical and chemical attributes of heart defect

Mouse brain models reveal insights into genetics of autism

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Tiny biological nanoparticles offer enormous potential for diagnostic and therapeutic applications

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