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Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

A new study describes two promising small molecules that inhibit a host cell factor, called nucleotide binding oligomerization domain-containing protein 2 (NOD2), that inhibits the replication and spread of many arboviruses. This could lead to the development of broad-spectrum antivirals. The study's findings have been published on the preprint server bioRxiv*.

10 Nov 2020

Novel super-activating macrophage receptor could explain hyper-inflammation in severe COVID-19

Immunity is a curious thing. While essential in protecting the body against invading pathogens and foreign antigens, it can also turn against the body and trigger destructive immunological processes. A new study published on the preprint server bioRxiv* in November 2020 reports on the role played by hyperactive macrophages in a range of acute and chronic hyper-inflammatory conditions.

10 Nov 2020

SARS-CoV-2 RNA genome structure reveals potential targets for development of drugs

The SARS-CoV-2 coronavirus RNA genome structure was studied in detail by researchers from the University of Groningen, the International Institute of Molecular and Cell Biology in Warsaw, and Leiden University.

10 Nov 2020

Clinical study of personalized cancer vaccine to expand after promising preliminary data

A clinical trial at the University of Arizona Health Sciences designed to study the safety and effectiveness of a personalized cancer vaccine in combination with the immunotherapy drug Pembrolizumab will expand its cohort after promising preliminary data was presented at the annual meeting of the Society for the Immunotherapy of Cancer.

10 Nov 2020

Optibrium Enters Cheminformatics Collaboration with MSD

Optibrium today announced a collaboration with MSD tradename of Merck & Co., Inc, Kenilworth NJ USA.

From Optibrium Ltd. 10 Nov 2020

Lupus Research Alliance announces the 2020 Lupus Innovation Awards

The Lupus Research Alliance proudly announced today the 2020 Lupus Innovation Awards. The projects represent a wide breadth of scientific exploration in lupus, probing the development and progression of lupus while pointing to potential treatment approaches.

10 Nov 2020

Insilico signs multi-target drug discovery agreement with Janssen Pharmaceutica

Insilico Medicine, a leader in deep generative reinforcement learning for target discovery, small molecule generation, and prediction of clinical trial outcomes, today announced that it entered into a multi-target drug discovery agreement with Janssen Pharmaceutica N.V. (Janssen).

10 Nov 2020

Researchers discover unique anti-cancer function for previously well-characterized protein

The development and progression of cancer is a complicated process that occurs when cells in the body grow out of control. Many different mechanisms and pathways that directly affect cell proliferation have been uncovered.

10 Nov 2020

Scientists observe GABAA receptors and their organization on synaptic membrane

Synapses are specialized devices where learning and memory occur. The efficient transmission of synaptic signals relies on the delicate structure and complex molecular composition of the synapses. However, the small size (several hundred nanometers in diameter) and heterogeneous nature of the synapses pose significant challenges in direct observation of the molecules inside synapses.

10 Nov 2020

Wake Forest Baptist scientists use pre-clinical model to develop a safe, effective flu vaccine for infants

Newborns and young infants are particularly susceptible to the flu and are six times more likely to die from the infection than older children. Currently there is no flu vaccine available for babies less than 6 months old.

9 Nov 2020

Research uncovers key to piercing dangerous bacteria's armor

Bacteria are single-celled organisms that are essential to human health, both in our environment and inside our own bodies. However, certain bacterial species can make us sick.

9 Nov 2020

Novel, highly specific treatment method for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine.

9 Nov 2020

ACE2 and TMPRSS2 not the only virus-receptors to mediate SARS-CoV-2 entry

However, a recent study published on the preprint server bioRxiv in November 2020 uncovers the major role played by the N-terminal domain of the SARS-CoV-2 virus in host infection. This could be of great use in measuring the usefulness of antibodies used in convalescent plasma therapy for COVID-19.

9 Nov 2020

Researchers identify new strategy to combat loss of skeletal muscle mass

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that stimulating expression of a protein naturally produced by the human body can be a strategy to combat loss of skeletal muscle mass, which happens normally with aging but can intensify in cases of neurodegenerative or inflammatory disease, or in patients who spend long periods in intensive care units (ICUs).

9 Nov 2020

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed photoresponsive derivatives of the anticancer drug Taxol, which allow light-based control of cytoskeleton dynamics in neurons. The agents can optically pattern cell division and may elucidate how Taxol acts.

9 Nov 2020

New strategy shows promises for treating RNA-repeat expansion disorders

A new strategy for treating a variety of diseases known as RNA-repeat expansion disorders, which affect millions of people, has shown promise in proof-of-principle tests conducted by scientists at Scripps Research.

8 Nov 2020

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

In a recent groundbreaking study, researchers from Stanford University demonstrated the potential of multiplexed targeted next-generation sequencing assay for detecting SARS-CoV-2 genetic fingerprints used in mutation profiling, with the potential of massive scalability required for population studies. The findings are currently available on the medRxiv preprint server.

8 Nov 2020

A new method to improve the preclinical evaluation of CAR T cell therapies

Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment.

6 Nov 2020

White blood cells can be used to attack tumors after completing a special training

Scientists at the National Center for Tumor Diseases Dresden and Dresden University Medicine, together with an international team of researchers, were able to demonstrate that certain white blood cells, so-called neutrophil granulocytes, can potentially - after completing a special training program - be utilized for the treatment of tumors.

6 Nov 2020

People of color with rheumatic disease have worse COVID-19 outcomes

New research at ACR Convergence, the American College of Rheumatology's annual meeting, reveals that people of color with rheumatic disease have worse health outcomes from COVID-19 infection, are more likely to be hospitalized to treat their coronavirus infection, and are more likely to require invasive ventilator treatment

6 Nov 2020

Molecule News and Research

Promising new antivirals target arboviruses and SARS-CoV-2: Nodosome inhibitors

Novel super-activating macrophage receptor could explain hyper-inflammation in severe COVID-19

SARS-CoV-2 RNA genome structure reveals potential targets for development of drugs

Clinical study of personalized cancer vaccine to expand after promising preliminary data

Optibrium Enters Cheminformatics Collaboration with MSD

Lupus Research Alliance announces the 2020 Lupus Innovation Awards

Insilico signs multi-target drug discovery agreement with Janssen Pharmaceutica

Researchers discover unique anti-cancer function for previously well-characterized protein

Scientists observe GABAA receptors and their organization on synaptic membrane

Wake Forest Baptist scientists use pre-clinical model to develop a safe, effective flu vaccine for infants

Research uncovers key to piercing dangerous bacteria's armor

Novel, highly specific treatment method for hyperinsulinemic hypoglycemia

ACE2 and TMPRSS2 not the only virus-receptors to mediate SARS-CoV-2 entry

Researchers identify new strategy to combat loss of skeletal muscle mass

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

New strategy shows promises for treating RNA-repeat expansion disorders

Study suggests SARS-CoV-2 mutation fingerprints could be used for molecular contact tracing

A new method to improve the preclinical evaluation of CAR T cell therapies

White blood cells can be used to attack tumors after completing a special training

People of color with rheumatic disease have worse COVID-19 outcomes

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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