Preclinical News and Research

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European scientists develop new handheld scanner for early-stage heart disease diagnosis

With worldwide cardiovascular deaths at an all-time high, European scientists have developed a new handheld scanner that can read your heart's vital signs like a supermarket barcode reader can scan items at the checkout, allowing a GP to diagnose even preclinical patients for the early onset of a disease.

6 Jul 2017

Second MILabs preclinical imaging system installed at University of Pennsylvania

The University of Pennsylvania (UPENN), Philadelphia, PA, has completed installation of its second MILabs preclinical imaging system, a scalable U-CTUHR microCT system in the lab of Prof. Joel Karp in the Department of Radiology at the University of Pennsylvania.

5 Jul 2017

SCT scientists develop Neo-Islet technology for treating insulin-dependent diabetes

The cover of the July 2017 issue of the journal STEM CELLS Translation Medicine showcases the latest advance toward a functional cure of insulin-dependent diabetes.

30 Jun 2017

Discovery of T cell exhaustion offers new pathway to more powerful immunotherapies

St. Jude Children's Research Hospital immunologists have discovered how immune cells called T cells become "exhausted" -- unable to do their jobs of attacking invaders such as cancer cells or viruses.

28 Jun 2017

Memories stored in same neuron can be selectively erased, study suggests

Different types of memories stored in the same neuron of the marine snail Aplysia can be selectively erased, according to a new study by researchers at Columbia University Medical Center (CUMC) and McGill University and published today in Current Biology.

22 Jun 2017

Researchers find new evidence that autoimmunity plays role in Parkinson's disease

Researchers have found the first direct evidence that autoimmunity- in which the immune system attacks the body's own tissues- plays a role in Parkinson's disease, the neurodegenerative movement disorder.

21 Jun 2017

Combination of immunotherapies effective against mouse model of rhabdomyosarcoma

Rhabdomyosarcoma, a cancer made up of cells that normally develop into skeletal muscles, is the most common soft tissue cancer in children. If it is detected early and localized in certain areas, rhabdomyosarcoma is usually curable with traditional therapies like surgery, radiation, and chemotherapy.

20 Jun 2017

New review finds massive problem of self-medication misuse in the Middle East

A new review indicates that there is a massive problem of self-medication misuse in the Middle East. The findings, which are published in Pharmacology Research & Perspectives, indicate the need for better patient and physician education, as well as improved policies that restrict sales of prescription medications without a prescription.

19 Jun 2017

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute, together with scientists from Mayo Clinic's Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).

15 Jun 2017

Biomedical engineering professor wins $2 million grant for concussion research

Barclay Morrison, professor of biomedical engineering at Columbia Engineering, has won a $2 million five-year grant from the Paul G. Allen Family Foundation to study the underlying mechanisms of concussion.

15 Jun 2017

Study reveals early indication of Alzheimer’s in adults with normal cognition

A new study led by the Keck School of Medicine of University of Southern California (USC) reveals that older adults with elevated levels of brain-clogging plaques, yet normal cognition, experience faster mental decline, suggestive of Alzheimer's disease. The study published in The Journal of the American Medical Association on June 13 presented the earliest precursor—the toxic and sticky protein as part of the disease, before symptoms arise.

15 Jun 2017

New approach could potentially prevent muscle wasting in muscular dystrophy and cancer

Monash University's Biomedicine Discovery Institute researchers have collaboratively developed a therapeutic approach that dramatically promotes the growth of muscle mass, which could potentially prevent muscle wasting in diseases including muscular dystrophy and cancer.

14 Jun 2017

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

A study published in the journal Cell on June 13 has found that a class of small molecules can successfully penetrate and darken human skin samples. The drug developed in the laboratory by researchers in Boston also generates protective tans in red-haired mice.

14 Jun 2017

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Older adults with elevated levels of brain-clogging plaques -- but otherwise normal cognition -- experience faster mental decline suggestive of Alzheimer's disease, according to a new study led by the Keck School of Medicine of USC that looked at 10 years of data.

13 Jun 2017

Altered virus could help more patients to become eligible for human gene therapy trials

For many patients, participating in gene therapy clinical trials isn't an option because their immune system recognizes and fights the helpful virus used for treatment.

13 Jun 2017

Study examines how sex alters time-course of inflammation in the brain after TBI

Male mice have much greater brain distress in the week following a traumatic brain injury (TBI) than female mice, including skyrocketing inflammation and nerve cell death, say researchers at Georgetown University Medical Center.

13 Jun 2017

Developing synthetic mediums for growing organoids

Organoids are bits of tissue grown in vitro, in a near-physiological 3D setting. The particularity consists in the fact that organoids retain features of the patient they are derived from, even when cultured outside of the human body. This is very different from what traditional, conventional cell culture has been able to do over the past 50 years or so.

13 Jun 2017

Preclinical News and Research

European scientists develop new handheld scanner for early-stage heart disease diagnosis

Second MILabs preclinical imaging system installed at University of Pennsylvania

SCT scientists develop Neo-Islet technology for treating insulin-dependent diabetes

Discovery of T cell exhaustion offers new pathway to more powerful immunotherapies

Memories stored in same neuron can be selectively erased, study suggests

Researchers find new evidence that autoimmunity plays role in Parkinson's disease

Combination of immunotherapies effective against mouse model of rhabdomyosarcoma

New review finds massive problem of self-medication misuse in the Middle East

TSRI scientist and partners receive $7.2 million grant to create new RNA-based treatments for ALS

Biomedical engineering professor wins $2 million grant for concussion research

Study reveals early indication of Alzheimer’s in adults with normal cognition

New approach could potentially prevent muscle wasting in muscular dystrophy and cancer

Researchers find molecule that darkens skin without UV exposure and may protect against skin cancer

USC scientists illuminate impact of early brain-clogging plaques on Alzheimer's disease

Altered virus could help more patients to become eligible for human gene therapy trials

Study examines how sex alters time-course of inflammation in the brain after TBI

Developing synthetic mediums for growing organoids

Researchers uncover molecule in newborn hearts that appears to control renewal process

Removal of senescent cells could delay onset of age-related pathologies

Researchers create 3D heart tissue from stem cells for drug testing

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