Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Prenatal risk factors linked with development of chronic kidney disease in children

Certain prenatal risk factors are associated with the development of chronic kidney disease in children, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). Future studies should investigate whether modifying these factors could help protect children's kidney health.

18 Apr 2014

First Edition: April 17, 2014

Today's headlines include reports about emerging political strategies related to the health law and the upcoming congressional elections.

17 Apr 2014

Understanding GPCRs and controlling inflammation: an interview with Dr. Richard Proia, NIDDK, NIH

GPCRs are one of the largest families of cellular signalling proteins consisting of more than a thousand different types. They reside on the surface membranes of cells where they are poised to recognize molecules in the exterior environment and then transmit this information through the membrane allowing cells to respond accordingly.

16 Apr 2014

Akebia completes enrollment in ongoing 200-patient Phase 2b study of AKB-6548

Akebia Therapeutics, Inc., a biopharmaceutical company focused on the development of novel proprietary therapeutics based on hypoxia-inducible factor (HIF) biology and the commercialization of these products for patients with kidney disease, today announced it has completed enrollment in its ongoing 200-patient Phase 2b study of AKB-6548 for the treatment of anemia associated with chronic kidney disease (CKD) in patients who are not dependent on dialysis.

16 Apr 2014

New blood test accurately detects presence of breast cancer and monitors response to treatment

Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment.

15 Apr 2014

Drugs used to treat osteoporosis appear to prevent cell membrane repair

A class of drugs widely used to treat osteoporosis appears to impede a cell's ability to repair a protective outer membrane that helps determine what enters and exits, researchers report.

15 Apr 2014

NEPHRON+ project improves lives of kidney failure patients by developing wearable artificial kidney device

End stage kidney disease is a global public health problem with an estimated 2.4 million patients on dialysis. The number of new cases is rising (7-8% annually) due to population ageing and increased diabetes prevalence.

15 Apr 2014

Scientists uncover mechanism and possible treatment to reverse immune suppression in liver disease patients

The mechanism which underlies the susceptibility of liver disease patients to life-threatening infection has been uncovered by Wellcome Trust-funded medical scientists, who have also suggested a possible treatment to reverse immune suppression in these patients.

15 Apr 2014

Lin28 gene may hold clues to regeneration of damaged kidneys in adults

Nearly one-third of cases of Wilms tumor, a pediatric cancer of the kidney, are linked to a gene called Lin28, according to research from Boston Children's Hospital. Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.

15 Apr 2014

Two candidate mTOR therapy biomarkers identified in RCC

Two genes, TSC1 and MTOR, warrant further investigation as biomarkers for treatment benefit with rapalogs in patients with renal cell carcinoma, indicate study results published in Clinical Cancer Research.

14 Apr 2014

Proteomics completes important milestone towards development of CDx test with validation of protein biomarkers

Proteomics now seeks a commercialisation partner to enter the RUO, LDT or IVD markets. Drug discovery company Proteomics International has completed an important milestone towards the development of a companion diagnostic (CDx) test with the validation of several of its protein biomarkers.

11 Apr 2014

Researchers reveal why Peel has one of highest rates of diabetes in Ontario

According to researchers at St. Michael's Hospital, there are two significant reasons why Peel has one of the highest rates of diabetes in Ontario: neighbourhood design that discourages walking and a population with many residents whose ethnic backgrounds predispose them to diabetes.

11 Apr 2014

RWJUH offers new alternative to open up blocked arteries

Treatment options for high-risk heart patients with severely calcified coronary artery disease (CAD) have been limited for more than 20 years. Now, Robert Wood Johnson University Hospital offers a new alternative to open up blocked arteries.

11 Apr 2014

Clinical Research Forum announces winners of third annual Top 10 Clinical Research Achievement Awards

The Clinical Research Forum has announced the winners of its third annual Top 10 Clinical Research Achievement Awards. The winning projects represent the outstanding examples of research projects that benefit the health and well-being of the general public.

11 Apr 2014

Loyola University Medical Center designated as Comprehensive Hypertension Center

Loyola University Medical Center has been approved as a Comprehensive Hypertension Center by the American Society of Hypertension. This designation recognizes centers that have demonstrated the highest level of expertise in treating patients with complex hypertension and co-existing medical conditions such as diabetes and chronic kidney disease.

11 Apr 2014

President of ASN urges Congress to spur scientific innovation in kidney research through federal prize competition

Today the President of the American Society of Nephrology (ASN) urged Congress to spur scientific innovation in kidney research through a federal prize competition.

10 Apr 2014

Mayo Clinic research shows RA patients more likely to develop chronic kidney disease

Rheumatoid arthritis patients are likelier than the average person to develop chronic kidney disease, and more severe inflammation in the first year of rheumatoid arthritis, corticosteroid use, high blood pressure and obesity are among the risk factors, new Mayo Clinic research shows.

10 Apr 2014

Genkyotex’s GKT137831 reverses lung fibrosis in new model of idiopathic pulmonary fibrosis

Genkyotex, the leading developer of selective NOX enzyme inhibitors, announced today the publication of data showing that GKT137831, a first in class NOX1 and 4 inhibitor, was able to reverse lung fibrosis associated with aging in a new model of idiopathic pulmonary fibrosis.

10 Apr 2014

Siemens, NKF form new alliance to improve screening for kidney disease in high-risk individuals

Siemens Healthcare and the National Kidney Foundation (NKF) announced today a new strategic alliance focusing on education, awareness and screening for kidney disease in high-risk individuals. This important collaboration will leverage the latest testing recommendations from the NKF to improve detection among the 73 million Americans at risk for kidney disease.

10 Apr 2014

Curis and Debiopharm present data for Debio 0932 at Annual Meeting of AACR

Curis, Inc., an oncology focused company developing novel, targeted drug candidates for the treatment of human cancers, and Debiopharm Group™ (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, including oncology as well as companion diagnostics, today announced presentation of data for Debio 0932 at the Annual Meeting of the American Association for Cancer Research (AACR) that demonstrated synergy between Debio 0932 and various standard of care (SOC) agents in multiple in vitro and xenograft models of non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC).

8 Apr 2014

Nephrology News and Research

Further Reading

Prenatal risk factors linked with development of chronic kidney disease in children

First Edition: April 17, 2014

Understanding GPCRs and controlling inflammation: an interview with Dr. Richard Proia, NIDDK, NIH

Akebia completes enrollment in ongoing 200-patient Phase 2b study of AKB-6548

New blood test accurately detects presence of breast cancer and monitors response to treatment

Drugs used to treat osteoporosis appear to prevent cell membrane repair

NEPHRON+ project improves lives of kidney failure patients by developing wearable artificial kidney device

Scientists uncover mechanism and possible treatment to reverse immune suppression in liver disease patients

Lin28 gene may hold clues to regeneration of damaged kidneys in adults

Two candidate mTOR therapy biomarkers identified in RCC

Proteomics completes important milestone towards development of CDx test with validation of protein biomarkers

Researchers reveal why Peel has one of highest rates of diabetes in Ontario

RWJUH offers new alternative to open up blocked arteries

Clinical Research Forum announces winners of third annual Top 10 Clinical Research Achievement Awards

Loyola University Medical Center designated as Comprehensive Hypertension Center

President of ASN urges Congress to spur scientific innovation in kidney research through federal prize competition

Mayo Clinic research shows RA patients more likely to develop chronic kidney disease

Genkyotex’s GKT137831 reverses lung fibrosis in new model of idiopathic pulmonary fibrosis

Siemens, NKF form new alliance to improve screening for kidney disease in high-risk individuals

Curis and Debiopharm present data for Debio 0932 at Annual Meeting of AACR

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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