Clinical Trial News and Research

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Researchers receive a combined $1 million grant to study RET-positive lung cancer

University of Colorado Cancer Center member Tejas Patil, MD, is one of three researchers to receive a combined $1 million grant from the Hamoui Foundation and LUNGevity Foundation to study RET-positive lung cancer.

21 Mar 2022

Researchers win NIH grant to treat human brain cancer with a drug previously used on canines

The National Institutes of Health is awarding a $3.8 million grant to John Rossmeisl, the Dr. and Mrs. Dorsey Taylor Mahin Professor of Neurology and Neurosurgery at the Virginia-Maryland College of Veterinary Medicine, and Waldemar Debinski, cancer biology professor at the Wake Forest School of Medicine.

21 Mar 2022

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

A team of clinical investigators at the Icahn School of Medicine at Mount Sinai has announced the launch of a Phase 1, open-label, placebo-controlled study to evaluate the safety and immunogenicity of an egg-based COVID-19 vaccine in healthy, vaccinated adults who have never been infected with COVID-19.

21 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people - but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

Researchers find effective nutritional strategies to prevent acute kidney injury

A research team led by Professor Dr Roman-Ulrich Müller has established that four out of six different nutritional strategies prevent acute kidney injury in the mouse model.

21 Mar 2022

NIH launches Molecular Characterization Initiative for pediatric tumors

In support of President Biden's Cancer Moonshot℠ goal of fostering data sharing in cancer research, the National Cancer Institute, part of the National Institutes of Health, has launched the Molecular Characterization Initiative for pediatric tumors.

21 Mar 2022

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show.

19 Mar 2022

Reactivating Piezo1 protein could help repair broken down, dystrophic muscles

One protein, Piezo1, is key to marshalling muscle stem cells' unique shapes and response to injuries, but it is in low supply in those with Duchenne muscular dystrophy, according to a team at the Perelman School of Medicine at the University of Pennsylvania.

18 Mar 2022

Researchers find ketamine to have significant anti-depressant and anti-suicidal effects

First manufactured more than 50 years ago, ketamine is a fast-acting dissociative anesthetic often used in veterinary and emergency medicine. Ketamine also has a history of being an illicit party drug.

18 Mar 2022

University of Kentucky begins world’s first clinical trial for LATE

The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

17 Mar 2022

Clinical utility of Roche assays determined utilizing samples from participants enrolled in a phase 2 trial of the mRNA-1273 vaccine

Researchers quantified the humoral immune response against the mRNA-1273 COVID-19 vaccine using commercially available high throughput assays.

17 Mar 2022

MHRA authorizes new medicine for COVID-19 prevention

A new medicine, Evusheld (tixagevimab/cilgavimab), has today been authorised for COVID-19 prevention by the Medicines and Healthcare products Regulatory Agency (MHRA) after meeting the UK regulatory standards of safety, quality and effectiveness.

17 Mar 2022

The safety and immunogenicity of NVSI-06-08 as a heterologous booster dose in adults previously vaccinated with BBIBP-CorV

Researchers assessed the safety profile and immunogenicity of a heterologous NVSI-06-08 boost against SARS-CoV-2 variants in individuals doubly vaccinated with the inactivated vaccine BBIBP-CorV.

17 Mar 2022

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

The first large-scale trial to test the long-term effects of a cocoa flavanol supplement to prevent cardiovascular disease offers promising signals that cocoa flavanols could have protective cardiovascular effects.

16 Mar 2022

Potential Covid-19 vaccine may offer an inexpensive, easy-to-store alternative to RNA vaccines

While many people in wealthier countries have been vaccinated against Covid-19, there is still a need for vaccination in much of the world.

16 Mar 2022

The Future of Tuberculosis; An Interview with the Bill & Melinda Gates Medical Research Institute

We speak to Dr. Alemnew Dagnew from the Bill & Melinda Gates Medical Research Institute, about their tuberculosis vaccine study and the future of tuberculosis.

16 Mar 2022

Serious COVID-19 linked to higher risk of long-term adverse mental health effects

A new study published in The Lancet Public Health journal indicates that serious COVID-19 illness is linked to an increase in the risk of long-term adverse mental health effects.

15 Mar 2022

Orally-active senolytics can boost a key beneficial protein in mice and humans

Mayo Clinic researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases.

15 Mar 2022

Antimicrobial prescribing among infants may be prevented using maternal RSV vaccines

RSV is a leading cause of severe acute lower respiratory tract infections (LRTIs) among infants globally, and a prominent contributor to common non-severe infections that account for high volumes of antibiotic consumption.

14 Mar 2022

Using mRNA to introduce gene editor into human muscle stem cells

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.

14 Mar 2022

Clinical Trial News and Research

Researchers receive a combined $1 million grant to study RET-positive lung cancer

Researchers win NIH grant to treat human brain cancer with a drug previously used on canines

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

Researchers find effective nutritional strategies to prevent acute kidney injury

NIH launches Molecular Characterization Initiative for pediatric tumors

Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

Reactivating Piezo1 protein could help repair broken down, dystrophic muscles

Researchers find ketamine to have significant anti-depressant and anti-suicidal effects

University of Kentucky begins world’s first clinical trial for LATE

Clinical utility of Roche assays determined utilizing samples from participants enrolled in a phase 2 trial of the mRNA-1273 vaccine

MHRA authorizes new medicine for COVID-19 prevention

The safety and immunogenicity of NVSI-06-08 as a heterologous booster dose in adults previously vaccinated with BBIBP-CorV

New trial finds signs of preventive cardiovascular effects for cocoa flavanols

Potential Covid-19 vaccine may offer an inexpensive, easy-to-store alternative to RNA vaccines

The Future of Tuberculosis; An Interview with the Bill & Melinda Gates Medical Research Institute

Serious COVID-19 linked to higher risk of long-term adverse mental health effects

Orally-active senolytics can boost a key beneficial protein in mice and humans

Antimicrobial prescribing among infants may be prevented using maternal RSV vaccines

Using mRNA to introduce gene editor into human muscle stem cells

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