Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

DNA enhancers switch on colorectal cancer genes to promote tumor growth, study finds

Genetic mutations can increase a person's cancer risk, but other gene "enhancer" elements may also be responsible for disease progression, according to new research out of Case Western Reserve University School of Medicine.

7 Mar 2017

Research findings could guide development of potent combination therapies for leukemia

New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia.

7 Mar 2017

Deep learning transforms the drug discovery process in collaboration between Insilico Medicine and Life Extension

In March 2016 Insilico Medicine initiated a research collaboration with Life Extension to apply advanced bioinformatic methods and deep learning algorithms to screen for naturally occurring compounds that may slow down or even reverse the cellular and molecular mechanisms of aging. Today Life Extension (LE) launched a new line of nutraceuticals called GEROPROTECTTM, and the first product in the series called Ageless CellTM combines some of the natural compounds that were shortlisted by Insilico Medicine’s algorithms and are generally recognized as safe (GRAS).

7 Mar 2017

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

Researchers at Okayama University report in Scientific Reports how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest over-expression tolerance.

7 Mar 2017

Researchers identify 90 genes in fat that could play key roles in cardiometabolic diseases

A sweeping international effort is connecting the dots between genes in our fat cells and our risk for obesity and cardiometabolic diseases such as heart disease and type 2 diabetes.

6 Mar 2017

Scientists use molecular bait strategy to capture and isolate cancer-prone protein

Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using 'molecular bait'.

2 Mar 2017

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults.

2 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Scientists identify potential therapeutic target for aggressive lymphomas

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have identified a possible therapeutic target for 2 types of very aggressive lymphomas.

28 Feb 2017

Stem cells strictly abide by innate developmental clocks, study shows

The mystery of what controls the range of developmental clocks in mammals — from 22 months for an elephant to 12 days for an opossum — may lie in the strict time-keeping of pluripotent stem cells for each unique species.

28 Feb 2017

Researchers identify genomic biomarker in nasal passage that can accurately detect lung cancer

A new nasal test may allow patients suspected of having lung cancer to undergo a simple swab of their nose to determine if they have the disease.

27 Feb 2017

Researchers identify genetic variants that may contribute to schizophrenia

New research has identified sections of DNA associated with altered regulation of gene expression underlying schizophrenia.

27 Feb 2017

New research reveals complex role of ‘master gene’ that regulates physical differences between sexes

Physical differences between males and females in species are common, but there remains much to learn about the genetic mechanisms behind these differences.

27 Feb 2017

MGH researchers discover regulators of gene expression programs in medulloblastoma

Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. In their report published online in Cancer Discovery, the team also identifies potential targets for future treatments.

24 Feb 2017

BUSM researchers uncover unique patterns of protein synthesis linked to increased longevity

Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model organisms. Yet, how these different aging genes and pathways are interconnected remains poorly understood.

23 Feb 2017

Lack of methyl groups in gene body may lead to emergence of cancer

Every cell in our body contains the complete DNA library. So-called methyl groups regulate that in body tissues only the genetic information is expressed that is indeed needed in this tissue.

23 Feb 2017

MSK researchers harness power of CRISPR/Cas9 to create more-potent CAR T cells

Researchers from Memorial Sloan Kettering Cancer Center have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in mice.

23 Feb 2017

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

22 Feb 2017

Study describes how bacteria can remodel gene expression to infect intestines of host

Hebrew University researchers have described how infectious bacteria can sense they're attached to our intestinal cells, and then remodel their expression of specific genes, including those involved in virulence and metabolism, to exploit our cells and colonize our gut.

22 Feb 2017

Epigenetic changes that affect formation of new muscle cells may be contributing factor to obesity

Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden.

22 Feb 2017

Gene Expression News and Research

Further Reading

DNA enhancers switch on colorectal cancer genes to promote tumor growth, study finds

Research findings could guide development of potent combination therapies for leukemia

Deep learning transforms the drug discovery process in collaboration between Insilico Medicine and Life Extension

Researchers reveal how overloading of protein transport mechanisms triggers cellular defects

Researchers identify 90 genes in fat that could play key roles in cardiometabolic diseases

Scientists use molecular bait strategy to capture and isolate cancer-prone protein

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Using Spherical Nucleic Acids to Track and Treat Disease

Scientists identify potential therapeutic target for aggressive lymphomas

Stem cells strictly abide by innate developmental clocks, study shows

Researchers identify genomic biomarker in nasal passage that can accurately detect lung cancer

Researchers identify genetic variants that may contribute to schizophrenia

New research reveals complex role of ‘master gene’ that regulates physical differences between sexes

MGH researchers discover regulators of gene expression programs in medulloblastoma

BUSM researchers uncover unique patterns of protein synthesis linked to increased longevity

Lack of methyl groups in gene body may lead to emergence of cancer

MSK researchers harness power of CRISPR/Cas9 to create more-potent CAR T cells

Study finds biochemical pathway that triggers regrowth of breast cancer stem cells after chemotherapy

Study describes how bacteria can remodel gene expression to infect intestines of host

Epigenetic changes that affect formation of new muscle cells may be contributing factor to obesity

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