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Lipidomics and metabolomics as potential biomarkers for breast cancer progression

This review highlights the potential of lipidomic and metabolomic biomarkers in predicting breast cancer prognosis and therapy response, enhancing patient care.

5 Sep 2024

New insights into stiff-person syndrome, advancing diagnosis and treatment

Research explores the complexities of diagnosing and treating stiff-person syndrome, emphasizing the uncertain role of GAD antibodies and the promise of novel therapies.

5 Sep 2024

Scientists advance type 1 diabetes treatment with cutting-edge stem cell and gene editing technologies

Researchers review significant advancements and ongoing challenges in cell replacement therapies for type 1 diabetes, highlighting innovative approaches in stem cell-derived islets and immune protection strategies.

5 Sep 2024

Anti-coagulant therapy fails to improve stroke outcomes in major study

Stroke patients who survive a blood clot in the brain's blood vessels are prone to developing new blockages during their recovery periods, even if they receive vessel-clearing interventions.

4 Sep 2024

Understanding the hormonal paradox in prostate cancer progression

A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced.

4 Sep 2024

Genetic variants linked to heart rhythm disturbances in Wolff-Parkinson-White Syndrome

Study by scientists at deCODE genetics/Amgen and collaborators in Denmark and the USA, on the genetics of accessory conduction pathways in the heart (Wolff-Parkinson-White syndrome), reveals that accessory pathways can cause rhythm disturbances, characterized by an overly fast heartbeat, which can be life-threatening.

4 Sep 2024

New immunotherapy approach shows promise for minimizing spinal cord injury damage

WashU Medicine researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells.

4 Sep 2024

Understanding the impact of BMI on colorectal cancer risk in Asia

Researchers report that body mass index values in Asians population may predict the risk of developing colorectal cancer.

4 Sep 2024

A novel therapeutic option for HER2-positive extramammary Paget disease

The research article presents a comprehensive evaluation of the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel humanized anti-HER2 antibody-drug conjugate (ADC), for this rare adenocarcinoma.

4 Sep 2024

Alirocumab reduces dangerous coronary plaque and stabilizes high-risk lesions

Intensive LDL-C lowering with alirocumab significantly reduces high-risk coronary plaque burden, transforming unstable plaques into more stable phenotypes. This lesion-level analysis underscores the enhanced efficacy compared to vessel-level approaches.

4 Sep 2024

AI model enhances detection of immune-related adverse events in cancer patients

While immune checkpoint inhibitors (ICIs) can provide lifesaving treatment for patients with cancer, they have also been found to cause immune-related adverse events (irAEs) - side effects that can impact almost every organ in the body to varying degrees.

3 Sep 2024

Ketamine clinics show inconsistent practices on pregnancy and contraception

More hospitals and clinics now offer patients ketamine therapy for severe depression, post-traumatic stress disorder and other mental health conditions that haven't responded to other treatments.

3 Sep 2024

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

The Mass General Brigham Gene and Cell Therapy Institute (GCTI) today announced it has launched the RNA Therapeutics Core, a first-of-its-kind, state-of-the-art facility and resource to advance the use of RNA technologies within and beyond the Mass General Brigham research ecosystem.

3 Sep 2024

Penn research uncovers key biomarker for diagnosing sarcoidosis

Sarcoidosis is a rare systemic disease that afflicts an estimated 200,000 people in the US, more often people who are Black and more women than men, particularly when it causes chronic skin disease.

3 Sep 2024

Researchers develop stable compound for targeted alpha therapy in prostate cancer

Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle.

3 Sep 2024

Study shows beta cells can function independently for glycemic control

Our glycemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, and diabetes develops.

3 Sep 2024

Hormonal treatment could delay biological aging among postmenopausal females

Hormone treatment in postmenopausal women is associated with lower biological aging discrepancies, particularly among those with lower socioeconomic status.

3 Sep 2024

Matcha green tea enhances cognition and sleep in older adults

Regular matcha green tea consumption may improve emotional perception and sleep quality in older adults with cognitive decline, though it shows no significant effect on broader cognitive functions.

2 Sep 2024

$FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction$

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Finerenone reduced heart failure (HF) events and cardiovascular death in patients with HF and mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Wearable heart monitor for AF screening increases diagnoses but not stroke prevention

Screening for atrial fibrillation (AF) using a wearable heart monitor for 2 weeks can identify older adults with this potentially dangerous abnormal heart rhythm, but does not prevent subsequent strokes, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug - 2 Sept).

2 Sep 2024

Therapy News and Research

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

New insights into stiff-person syndrome, advancing diagnosis and treatment

Scientists advance type 1 diabetes treatment with cutting-edge stem cell and gene editing technologies

Anti-coagulant therapy fails to improve stroke outcomes in major study

Understanding the hormonal paradox in prostate cancer progression

Genetic variants linked to heart rhythm disturbances in Wolff-Parkinson-White Syndrome

New immunotherapy approach shows promise for minimizing spinal cord injury damage

Understanding the impact of BMI on colorectal cancer risk in Asia

A novel therapeutic option for HER2-positive extramammary Paget disease

Alirocumab reduces dangerous coronary plaque and stabilizes high-risk lesions

AI model enhances detection of immune-related adverse events in cancer patients

Ketamine clinics show inconsistent practices on pregnancy and contraception

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

Penn research uncovers key biomarker for diagnosing sarcoidosis

Researchers develop stable compound for targeted alpha therapy in prostate cancer

Study shows beta cells can function independently for glycemic control

Hormonal treatment could delay biological aging among postmenopausal females

Matcha green tea enhances cognition and sleep in older adults

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Wearable heart monitor for AF screening increases diagnoses but not stroke prevention

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