Clinical Trial News and Research

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Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

Results from an international, randomized, double-blind, placebo-controlled, phase 3 clinical trial indicate that adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy prolongs the survival of men with metastatic, hormone-sensitive prostate cancer, a disease that is fatal in most cases.

18 Feb 2022

New combination of antiviral drugs fails to improve outcomes in hospitalized patients with influenza

A new combination of antiviral drugs did not improve clinical outcomes in hospitalized patients with severe influenza, according results from a recent clinical trial published in The Lancet Infectious Diseases.

18 Feb 2022

Two forms of heart bypass surgery provide similar patient outcomes, study reveals

A new study that monitors patients who received "on-pump" or "off-pump" coronary artery bypass grafting (CABG) over a 10-year period reveals that outcomes between the two forms of heart bypass surgery are not much different.

18 Feb 2022

SARS-CoV-2 Mpro inhibitor, nirmatrelvir, found to reduce COVID-19 progression and death

In a new study, researchers evaluated the efficacy and safety of nirmatrelvir in mild to moderate COVID-19 patients who were at high risk of severe COVID-19 disease.

18 Feb 2022

Immunogenicity, efficacy, and safety of BNT162b2 or mRNA1273 fourth dose

A recent study explored the safety, immunogenicity, and VE of the SARS-CoV-2 mRNA BNT162b2 and mRNA1273 vaccines against its Omicron VOC in HCWs in Israel.

18 Feb 2022

Study to evaluate efficacy of higher dose of ivermectin for treating mild-to-moderate COVID-19

A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University has expanded its testing platform to evaluate ivermectin at a higher dose for a longer period of time.

17 Feb 2022

MRI screenings may reduce breast-cancer mortality in women with 3 pathogenic gene variants

Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis to be published Feb. 17, 2022, in JAMA Oncology.

17 Feb 2022

Treatment found to be safe, efficacious in improving insomnia and night sweats among midlife women

Hot flashes and night sweats are a common cause of insomnia among peri- and postmenopausal women. Hot flashes, night sweats and insomnia are all linked to reduced quality of life and distress.

17 Feb 2022

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Joint study will assess clinical value of comprehensive genomic profiling (CGP) on cancer therapy options in patients with advanced disease

From Illumina, Inc. 17 Feb 2022

UVMCC researchers address new paradigms in rectal cancer multidisciplinary care

In recent years total neoadjuvant treatment (TNT) - a potent new treatment approach for advanced colorectal cancer that confronts tumors with aggressive rounds of chemotherapy and chemoradiation followed by surgery to remove the cancerous tissue - has emerged as the standard of care.

16 Feb 2022

Gut enzymes open a gateway to create universal blood-type donor organs

A study published in Science Translational Medicine performed at the Latner Thoracic Surgery Research Laboratories and UHN's Ajmera Transplant Centre has proved that it is possible to convert blood type safely in donor organs intended for transplantation.

16 Feb 2022

UC joins nationwide trial to evaluate efficacy of repurposed drugs for mild-to-moderate COVID-19

The University of Cincinnati is joining a nationwide study to evaluate repurposed medications in the search for effective, safe treatments for mild-to-moderate COVID-19. Repurposed medications are those already approved by the U.S. Food and Drug Administration for other indications.

16 Feb 2022

Pioneering treatment for stroke due to intracerebral hemorrhage

For decades, University of Cincinnati researchers have been pioneers in the field of stroke research.

16 Feb 2022

Study reveals high prevalence of female pattern hair loss in postmenopausal women

Both men and women are more likely to lose their hair with age. Women also have the added risk associated with declines in estrogen levels during the menopause transition.

16 Feb 2022

Inside the tactical tug of war over the controversial Alzheimer’s drug

The drug industry, patient advocates, and congressional Republicans have all attacked federal officials' decision to decline routine Medicare coverage for a controversial Alzheimer's drug.

16 Feb 2022

Biomarker could predict pathologic response to chemotherapy among bladder cancer patients

Long-term survival data from the first prospective, randomized biomarker validation trial in patients with muscle-invasive bladder cancer being treated with cisplatin-based chemotherapy before surgery will be reported at the 2022 Genitourinary Cancers Symposium of the American Society of Clinical Oncology (GU ASCO) on February 18, 2022.

15 Feb 2022

New drug effective in patients with muscle-invasive bladder cancer ineligible for cisplatin chemotherapy

Findings from a new study led by Yale Cancer Center researchers show enfortumab vedotin is effective in patients with muscle-invasive bladder cancer (MIBC) not eligible for cisplatin chemotherapy.

15 Feb 2022

A third known case of HIV remission involving stem cell transplant documented

A woman with HIV who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months despite cessation of antiretroviral therapy (ART), according to a presentation at today's Conference on Retroviruses and Opportunistic Infections (CROI).

15 Feb 2022

Post-vaccination titers of neutralizing antibodies revealed as a moderate predictor of vaccine-induced immunity

In a new study, researchers investigated whether neutralizing antibodies against the SARS-CoV-2 spike protein offered adequate immunity against breakthrough infections among vaccinated individuals.

15 Feb 2022

Study explores the gut microbiome of COVID-19 patients

Researchers investigated the changes in the gut microbiome and the presence of SARS-CoV-2 in stool samples of COVID-19 patients.

14 Feb 2022

Clinical Trial News and Research

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

New combination of antiviral drugs fails to improve outcomes in hospitalized patients with influenza

Two forms of heart bypass surgery provide similar patient outcomes, study reveals

SARS-CoV-2 Mpro inhibitor, nirmatrelvir, found to reduce COVID-19 progression and death

Immunogenicity, efficacy, and safety of BNT162b2 or mRNA1273 fourth dose

Study to evaluate efficacy of higher dose of ivermectin for treating mild-to-moderate COVID-19

MRI screenings may reduce breast-cancer mortality in women with 3 pathogenic gene variants

Treatment found to be safe, efficacious in improving insomnia and night sweats among midlife women

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

UVMCC researchers address new paradigms in rectal cancer multidisciplinary care

Gut enzymes open a gateway to create universal blood-type donor organs

UC joins nationwide trial to evaluate efficacy of repurposed drugs for mild-to-moderate COVID-19

Pioneering treatment for stroke due to intracerebral hemorrhage

Study reveals high prevalence of female pattern hair loss in postmenopausal women

Inside the tactical tug of war over the controversial Alzheimer’s drug

Biomarker could predict pathologic response to chemotherapy among bladder cancer patients

New drug effective in patients with muscle-invasive bladder cancer ineligible for cisplatin chemotherapy

A third known case of HIV remission involving stem cell transplant documented

Post-vaccination titers of neutralizing antibodies revealed as a moderate predictor of vaccine-induced immunity

Study explores the gut microbiome of COVID-19 patients

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