Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

16 Jan 2017

Nanoparticle exposure can trigger dormant viruses in lung tissue cells

Nanoparticles from combustion engines can activate viruses that are dormant in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German Center for Lung Research, which has now been published in the journal 'Particle and Fibre Toxicology'.

16 Jan 2017

Endogenous retroviruses may have played significant role in development of the brain

Over millions of years retroviruses have been incorporated into our human DNA, where they today make up almost 10 per cent of the total genome.

12 Jan 2017

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Illumina, Inc. and Bio-Rad Laboratories, Inc. today announced the launch of the Illumina® Bio-Rad® Single-Cell Sequencing Solution at the J.P. Morgan Healthcare Conference. The comprehensive solution is the first next-generation sequencing (NGS) workflow for single-cell analysis, providing researchers the ability to investigate the coordinated contribution of individual cells in tissue function, disease progression, and therapeutic response.

From Illumina, Inc. 12 Jan 2017

Inhibition of EZH2 protein could be new strategy to treat multiple myeloma

In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease.

12 Jan 2017

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Tokyo Institute of Technology research: Gravitational biology: Real time imaging and transcriptome analysis of medaka aboard space station

11 Jan 2017

Researchers identify new subgroup of cervical cancers with different genetic features

A team of University of South Carolina scientists led by Carolyn Banister and Phillip Buckhaults has identified a new subtype of cervical cancer that, like most cervical cancers, is triggered by human papillomavirus (HPV) but whose growth is not directed by the virus, suggesting that therapy targeting these tumors' distinct genomic pathways may improve patient outcomes over standard treatment.

11 Jan 2017

Scientists identify molecular pathway in the brain that may help find better treatments for dementia

Rutgers University scientists have discovered a molecular pathway in the brain that may help provide answers to long-term memory problems in the elderly and aid researchers in identifying drug-based therapies to prevent dementia.

11 Jan 2017

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver.

9 Jan 2017

FDA-approved, bioengineered living-cell therapy can shift genomic profile of non-healing wounds

Apligraf - an FDA-approved, bioengineered living-cell therapy from Organogenesis Inc. - has become the first wound-healing therapy to demonstrate a significant change in the genomic profile of a treated non-healing wound, according to new research published in the peer-reviewed journal Science Translational Medicine.

6 Jan 2017

How does the brain control appetite?

Energy balance between energy intake and expenditure in our bodies is important for maintaining energy homeostasis to keep our bodies functioning properly. The appetite determines how much we eat, the energy intake, by communication between the brain and body.

4 Jan 2017

Research findings on sweat glands have potential to improve methods for culturing skin grafts

As early humans shed the hairy coats of their closest evolutionary ancestors, they also gained a distinct feature that would prove critical to their success: a type of sweat gland that allows the body to cool down quickly. Those tiny glands are enormously useful, allowing us to live in a wide variety of climates, and enabling us to run long distances.

4 Jan 2017

Study shows new role of zinc in optic nerve injury

For more than two decades, researchers have tried to regenerate the injured optic nerve using different growth factors and/or agents that overcome natural growth inhibition.

3 Jan 2017

NIH researchers identify molecular mechanisms that may underlie woman's susceptibility to PMDD

National Institutes of Health researchers have discovered molecular mechanisms that may underlie a woman's susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period.

3 Jan 2017

IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

The German Institute for Quality and Efficiency in Health Care (IQWiG) investigated the benefit of biomarker tests to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2-negative breast cancer and up to 3 affected lymph nodes.

30 Dec 2016

Studies in non-human primates provide more predictive results in genetic causes of blindness

Many gene therapy-based approaches are in development to combat genetic and other causes of blindness and vision loss, and much can be learned about the safety and effectiveness of these promising new therapies by studying them first in non-human primates before initiating clinical trials, as shown by the results of a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

29 Dec 2016

Gene Expression News and Research

Further Reading

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Nanoparticle exposure can trigger dormant viruses in lung tissue cells

Endogenous retroviruses may have played significant role in development of the brain

Equipment for single-cell genomics launched by Illumina and Bio-Rad

Inhibition of EZH2 protein could be new strategy to treat multiple myeloma

Real-time study of medaka fish aboard ISS sheds light on bone metabolism under microgravity

Researchers identify new subgroup of cervical cancers with different genetic features

Scientists identify molecular pathway in the brain that may help find better treatments for dementia

Epigenetic changes favor development of fatty liver in humans and mice

FDA-approved, bioengineered living-cell therapy can shift genomic profile of non-healing wounds

How does the brain control appetite?

Research findings on sweat glands have potential to improve methods for culturing skin grafts

Study shows new role of zinc in optic nerve injury

NIH researchers identify molecular mechanisms that may underlie woman's susceptibility to PMDD

IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

Studies in non-human primates provide more predictive results in genetic causes of blindness

Researchers explore how neuronal activity influences CREB dynamics

C elegans could be powerful model for understanding how nervous systems produce behaviors

New findings about key cellular protein could lead to treatments for neurodegenerative diseases

Ionis announces FDA approval of first SMA drug in the U.S for pediatric and adult patients

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