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Study reveals how immune cells sacrifice themselves to help fight off infections

Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection.

1 Oct 2020

Compounds repurposed from malaria treatment can kill diarrheal pathogen

A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new study.

1 Oct 2020

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

Tumors come in many shapes and forms--curable or deadly, solid or liquid, lodged inside the brain, bone, or other tissues. One thing they all have in common, however, is a knack for molecular deceit.

1 Oct 2020

Researchers identify a potential target for small cell lung cancer

The cover for issue 39 of Oncotarget features Figure 4, "Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves," by Yotsumoto, et al. which reported that the authors identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1.

1 Oct 2020

New technology helps detect receptors that respond to odor of cigarette smoke

A recent publication in the Journal of Neuroscience by a group of researchers at the University of Kentucky looks at Encoding the Odor of Cigarette Smoke. Tim McClintock, a physiology professor at UK, says their work lays a foundation for two things.

1 Oct 2020

Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage

In a recent preprint paper published on the medRxiv server, researchers demonstrated their investigation of fatal COVID-19 patients to assess infection in various cell types and the extent of damage it caused to the lung tissues.

30 Sep 2020

Skoltech researchers identify new panel of potential biomarkers for liver cancer diagnosis

A group of Skoltech scientists led by a Skoltech and MSU professor Olga Dontsova discovered a novel liver-specific non-coding RNA.

30 Sep 2020

UM171 molecule saves life of young man suffering from severe aplastic anemia

In a world first, a young man suffering from severe aplastic anemia who could not be helped by standard treatments has been given a life-saving blood transplant with the made-in-Canada UM171 molecule.

30 Sep 2020

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in human cell studies, bind and destroy the pandemic coronavirus' so-called "frameshifting element" to stop the virus from replicating.

30 Sep 2020

Novel nasal treatment could protect people from COVID-19

A novel nasal treatment developed to boost the natural human immune system to fight common colds and flu, has proved remarkably successful in reducing COVID-19 viral replication test results, released today, reveal.

30 Sep 2020

Study reveals unexpected mechanisms involved in working memory

Working memory: it's how you make a mental shopping list without forgetting the milk, or memorize a number just long enough to write it down.

29 Sep 2020

Researchers identify cells responsible for cardiac damage repair after infarction

Researchers at Cima and the Clinica Universidad de Navarra (Spain) have led an international study identifying the cardiac cells responsible for repairing the damage to this organ after infarction.

29 Sep 2020

Antibody improves progression-free survival in patients with advanced prostate cancer

An antibody for treating advanced prostate cancer improves progression-free survival in patients with metastasised, castration-resistant prostate cancer.

29 Sep 2020

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020

UCLA researchers receive $13 million NIH grant to combat melanoma

UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.

28 Sep 2020

Genetic testing is cost-effective, beneficial for newly diagnosed patients with metastatic GIST

Because gastrointestinal stromal tumors (GIST) are sensitive to the targeted small molecule therapy imatinib, oncologists tend to treat all patients with metastatic GIST with this drug. However, because this rare type of cancer is caused by different genetic mutations, imatinib does not help all patients equally.

28 Sep 2020

New framework allows researchers to probe the metabolic processes inside cancer cells

One of the biggest challenges to the development of medical treatments for cancer is the fact that there is no single kind of cancer.

28 Sep 2020

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Now in new research published on the preprint server bioRxix*, a novel formulation of the drug Niclosamide (NIC) is observed to be effective against SARS-CoV-2 and MERS-CoV in mouse models; it also protects against methicillin-resistance Staphylococcus aureus pneumonia and inflammatory lung damage.

28 Sep 2020

Researchers elucidate the impact of genetic mutations in cocaine addiction

Cocaine addiction is a chronic disorder with a high rate of relapse for which no effective treatment is currently available.

26 Sep 2020

New optical switch to precisely control the lifespan of genetic 'copies'

A novel optical switch makes it possible to precisely control the lifespan of genetic "copies". These are used by the cell as building instructions for the production of proteins.

25 Sep 2020

Molecule News and Research

Study reveals how immune cells sacrifice themselves to help fight off infections

Compounds repurposed from malaria treatment can kill diarrheal pathogen

Study shows how cancer cells gain access to nerve signal to enter the bloodstream

Researchers identify a potential target for small cell lung cancer

New technology helps detect receptors that respond to odor of cigarette smoke

Lung tissue in fatal COVID-19 shows broad cell tropism and extensive damage

Skoltech researchers identify new panel of potential biomarkers for liver cancer diagnosis

UM171 molecule saves life of young man suffering from severe aplastic anemia

Researchers create drug-like compounds to destroy coronavirus' frameshifting element

Novel nasal treatment could protect people from COVID-19

Study reveals unexpected mechanisms involved in working memory

Researchers identify cells responsible for cardiac damage repair after infarction

Antibody improves progression-free survival in patients with advanced prostate cancer

Phase 1 trial of new class of drugs shows promise in range of advanced cancers

UCLA researchers receive $13 million NIH grant to combat melanoma

Genetic testing is cost-effective, beneficial for newly diagnosed patients with metastatic GIST

New framework allows researchers to probe the metabolic processes inside cancer cells

Special formulation of inhaled niclosamide may be effective against SARS-CoV-2

Researchers elucidate the impact of genetic mutations in cocaine addiction

New optical switch to precisely control the lifespan of genetic 'copies'

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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