Preclinical News and Research

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Review discusses how neglect of sex differences in obesity research can affect treatment in females

One of the environmental factors that promote obesity, and the consequent health problems, are energy dense diets.

31 Jan 2017

Rice chemists synthesize new, improved contrast agents for real-time tracking of stem cells in the body

Rice University researchers have synthesized a new and greatly improved generation of contrast agents for tagging and real-time tracking of stem cells in the body.

31 Jan 2017

Researchers discover genes that could serve as therapeutic targets to reverse Rett syndrome

Researchers have uncovered 30 genes that could, one day, serve as therapeutic targets to reverse Rett syndrome, a rare neurological disorder that affects only girls and is a severe form of an autism spectrum disorder.

31 Jan 2017

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

A handful of FDA-approved drugs exist for treating individuals with alcohol use disorder but they have been largely ineffective at reducing the high rates of relapse. As such, there remains a critical need to identify and develop alternative pharmacological treatment options.

31 Jan 2017

Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI

An international consortium of academic research institutions have been awarded a $21 million grant from the National Institutes of Health to develop better ways to prevent epilepsy in patients who have suffered traumatic brain injuries.

30 Jan 2017

Researchers discover that existing anti-gout drug can reduce severity of opioid withdrawal symptoms

Opioid use and abuse is a significant social, health and economic issue in Canada. Researchers at the University of Calgary's Faculty of Veterinary Medicine and Hotchkiss Brain Institute have discovered that an existing anti-gout medication is effective in reducing the severity of withdrawal symptoms in opioid-dependent rodents.

30 Jan 2017

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

Standards for authorizing first-time trials of drugs in humans are lax, and should be strengthened in several ways, McGill University researchers argue in a paper published today in Nature.

30 Jan 2017

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

The Addario Lung Cancer Medical Institute, the Bonnie J. Addario Lung Cancer Foundation and Scancell Holdings PLC today announce a collaboration to evaluate the use of Scancell's second innovative cancer vaccine, SCIB2, from its ImmunoBody platform to treat non-small cell lung cancer.

30 Jan 2017

Cellectricon, Censo Biotechnologies launch joint technology access program to accelerate CNS and pain research

Cellectricon AB and Censo Biotechnologies Ltdare announcing the introduction of a joint technology access program for a fully humanized phenotypic screening platform targeting preclinical neuroscience and chronic pain research.

28 Jan 2017

Missing gene may cause kidney and urinary tract defects in people with DiGeorge syndrome

Loss of function of the CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome, a multinational team of scientists led by Columbia University Medical Center has found.

25 Jan 2017

Vagus nerve stimulation may hold potential to reduce drug cravings, study shows

A new preclinical study led by a University of Texas at Dallas researcher shows that vagus nerve stimulation (VNS) therapy might have the potential to help people overcome drug addiction by helping them learn new behaviors to replace those associated with seeking drugs.

24 Jan 2017

Researchers evaluate use of regenerative human umbilical cord for in-utero spina bifida repair

In a study to be presented Saturday, Jan. 28, in the oral concurrent session at 8:45 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, researchers evaluated a possible regenerative patch by using human umbilical cord in two studies titled Cryopreserved Human Umbilical Cord (HUC) vs Acellular Dermal Matrix (ADM) for In-Utero Spina Bifida Repair and the study Conventional vs cryopreserved human umbilical cord (HUC) patch based on repair for in-utero spina bifida in a sheep model.

23 Jan 2017

Bruker is to be key International Phenome Centre Network corporate partner for NMR Technologies and SOPs

The International Phenome Centre Network (IPCN), founded by Imperial College London and more than a dozen international partners in Australia, Canada, China, Japan, Singapore, Taiwan, the US, and the UK (www.phenomenetwork.org), was launched officially this week at the 2016 World Innovation Summit for Health (WISH) conference in Doha, Qatar. This global network is a critical link between leading research centers across the world and will support research into some of today’s most pressing global health challenges.

From Bruker 23 Jan 2017

Researchers uncover mechanism of resistance used by triple negative breast cancer

Breast cancer cells are evasive, finding ways to bypass drugs designed to stop their unchecked growth.

20 Jan 2017

Tau pathology underlies deterioration of spatial cognition in Alzheimer's disease

Columbia University Medical Center researchers have discovered that the spatial disorientation that leads to wandering in many Alzheimer's disease patients is caused by the accumulation of tau protein in navigational nerve cells in the brain.

20 Jan 2017

New genital herpes vaccine candidate shows promising results in preclinical tests

Approximately 500 million people around the world are infected with the genital herpes virus known as herpes simplex virus 2 (HSV2).

20 Jan 2017

Study examines differences in liver damage between binge drinkers and heavy drinkers

Alcoholic liver disease (ALD) occurs on a spectrum of severity. The majority of people who drink excessively develop a fatty liver, which though often symptom free, can progress to a state of inflammation, fibrosis, and cell death that can be fatal.

20 Jan 2017

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer.

19 Jan 2017

MR Solutions offers compact 7T cryogen-free preclinical MRI imaging system

Size really does matter when laboratories specify preclinical MRI imaging technology – in fact space is at such a premium that insufficient floor area often precludes purchase. The high field Flexiscan and Powerscan cryogen-free systems from MR Solutions have a compact design and are simply wheeled in and connected to the mains and other services whilst providing state of the art imaging.

17 Jan 2017

Functional deficits caused by mini-strokes can last longer than previously thought

Evidence overwhelmingly supports a link between cognitive decline and cerebrovascular diseases such as atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Not only do individuals with cerebrovascular diseases have a much higher incidence of cortical microinfarcts (mini-strokes), but post-mortem histological and in vivo radiological studies also find that the burden of microinfarcts is significantly greater among people with vascular cognitive impairment and dementia (VCID) than in age-matched, non-demented individuals.

16 Jan 2017

Preclinical News and Research

Review discusses how neglect of sex differences in obesity research can affect treatment in females

Rice chemists synthesize new, improved contrast agents for real-time tracking of stem cells in the body

Researchers discover genes that could serve as therapeutic targets to reverse Rett syndrome

Novel potassium channel genes could be promising therapeutic targets for alcohol use disorder

Research consortium awarded $21 million NIH grant to find ways to prevent epilepsy in patients with TBI

Researchers discover that existing anti-gout drug can reduce severity of opioid withdrawal symptoms

First-time drug trials launched on basis of flimsy, under-scrutinized evidence, say McGill researchers

ALCMI and Scancell collaborate to advance cancer vaccine clinical trials in NSCLC patients

Cellectricon, Censo Biotechnologies launch joint technology access program to accelerate CNS and pain research

Missing gene may cause kidney and urinary tract defects in people with DiGeorge syndrome

Vagus nerve stimulation may hold potential to reduce drug cravings, study shows

Researchers evaluate use of regenerative human umbilical cord for in-utero spina bifida repair

Bruker is to be key International Phenome Centre Network corporate partner for NMR Technologies and SOPs

Researchers uncover mechanism of resistance used by triple negative breast cancer

Tau pathology underlies deterioration of spatial cognition in Alzheimer's disease

New genital herpes vaccine candidate shows promising results in preclinical tests

Study examines differences in liver damage between binge drinkers and heavy drinkers

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

MR Solutions offers compact 7T cryogen-free preclinical MRI imaging system

Functional deficits caused by mini-strokes can last longer than previously thought

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