Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

New research shows that exercise changes expression of innate DNA

Exercise, even in small doses, changes the expression of our innate DNA. New research from Lund University in Sweden has described for the first time what happens on an epigenetic level in fat cells when we undertake physical activity.

4 Jul 2013

Duke researchers solve some mysteries related to the use of aspirin

Aspirin has been widely used for more than 50 years as a common, inexpensive blood thinner for patients with heart disease and stroke, but doctors have little understanding of how it works and why some people benefit and others don't.

4 Jul 2013

3-gene signature test will improve care of kidney transplant patients

A breakthrough non-invasive test can detect whether transplanted kidneys are in the process of being rejected, as well as identify patients at risk for rejection weeks to months before they show symptoms, according to a study published in The New England Journal of Medicine (NEJM).

4 Jul 2013

Human gene expression mechanism opens new therapeutic strategies against neurological disease

In a study that could change the way scientists view the process of protein production in humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNA.

4 Jul 2013

Study offers new insights into how genome gets regulated by signalling molecules within human cells

There's not much difference between what makes a man and what makes his beer - at least at the molecular level - according to a new study led by Professor John Schwabe at the University of Leicester.

2 Jul 2013

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

Vitamin C affects whether genes are switched on or off inside mouse stem cells, and may thereby play a previously unknown and fundamental role in helping to guide normal development in mice, humans and other animals, a scientific team led by UC San Francisco researchers has discovered.

2 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

RORA: A novel candidate gene for autism regulates large number of other genes

A new study by Valerie Hu, Ph.D., professor of biochemistry and molecular medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), reports that RORA, a novel candidate gene for autism discovered by her group in a 2010 study, regulates a large number of other genes associated with autism.

2 Jul 2013

Study: Pluripotent stem cell line-derived neurons survive and respond to cues in the primate brain

A team of researchers from Rush University, Yale University, the University of Colorado and the St. Kitts Biomedical Research Foundation transplanted human embryonic stem cells into primate laboratory animals modeled with Parkinson's disease and found "robust survival" of the cells after six weeks and indications that the cells were "well integrated" into the host animals.

29 Jun 2013

RUCDR Infinite Biologics receives $44.5 million Cooperative Agreement award from NIMH centre

RUCDR Infinite Biologics, the world's largest university-based biorepository, received a $44.5 million Cooperative Agreement award from the National Institute of Mental Health earlier this month to support its NIMH Center for Collaborative Genomics Research on Mental Disorders, which provides services to NIMH-funded scientists engaged in genomic research on mental disorders.

28 Jun 2013

Forced elongation of telomeres promotes differentiation of cancer cells

Researchers from the Japanese Foundation for Cancer Research in Tokyo have discovered that forced elongation of telomeres (extensions on the end of chromosomes) promotes the differentiation of cancer cells, probably reducing malignancy, which is strongly associated with a loss of cell differentiation.

28 Jun 2013

Genetic elements from plants entering into eater's bloodstream turn out to be 'false positive'

In 2011 and 2012, research from China's Nanjing University made international headlines with reports that after mice ate, bits of genetic material from the plants they'd ingested could make it into their bloodstreams intact and turn the animals' own genes off.

27 Jun 2013

Scientists compare DNA sequences, genes of domestic and wild tomatoes

You say tomato, I say comparative transcriptomics. Researchers in the U.S., Europe and Japan have produced the first comparison of both the DNA sequences and which genes are active, or being transcribed, between the domestic tomato and its wild cousins.

27 Jun 2013

Prader-Willi syndrome results in dysregulation of circadian and metabolic genes

Researchers with the UC Davis MIND Institute and Agilent Laboratories have found that Prader-Willi syndrome - a genetic disorder best known for causing an insatiable appetite that can lead to morbid obesity - is associated with the loss of non-coding RNAs, resulting in the dysregulation of circadian and metabolic genes, accelerated energy expenditure and metabolic differences during sleep.

26 Jun 2013

PLK1 crucial for proper functioning of cancer cells, researchers reveal

One of the main indicators for determining the activity of a tumour or cancer is cell division. Cancer cells divide more than other types and the genes and molecules involved in the process of division are, often, targets for identifying and treating certain types of cancer.

26 Jun 2013

Scientists examine molecular similarities in human and canine B-cell lymphoma

Humans and their pet dogs are close, so close that they both develop a type of cancer called diffuse large B-cell lymphoma. In humans it's the most common lymphoma subtype while in dogs, it's one of the most common cancers in veterinary oncology.

26 Jun 2013

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC).

24 Jun 2013

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Researchers from the Polytechnic Institute of New York University and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

21 Jun 2013

Researchers discover key role of RAP1 gene in obesity

The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, a gene that protects telomeres- the ends of chromosomes-after researchers from the Spanish National Cancer Research Centre surprisingly discovered its key role in obesity.

21 Jun 2013

Stress exposure may be associated with increased risk of aggressive breast cancer

Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of breast cancer, researchers from the University of Chicago report in the July 2013 issue of the journal Cancer Prevention Research.

19 Jun 2013

Gene Expression News and Research

Further Reading

New research shows that exercise changes expression of innate DNA

Duke researchers solve some mysteries related to the use of aspirin

3-gene signature test will improve care of kidney transplant patients

Human gene expression mechanism opens new therapeutic strategies against neurological disease

Study offers new insights into how genome gets regulated by signalling molecules within human cells

UCSF researchers find that vitamin C may help stem cells, in vitro fertilization

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

RORA: A novel candidate gene for autism regulates large number of other genes

Study: Pluripotent stem cell line-derived neurons survive and respond to cues in the primate brain

RUCDR Infinite Biologics receives $44.5 million Cooperative Agreement award from NIMH centre

Forced elongation of telomeres promotes differentiation of cancer cells

Genetic elements from plants entering into eater's bloodstream turn out to be 'false positive'

Scientists compare DNA sequences, genes of domestic and wild tomatoes

Prader-Willi syndrome results in dysregulation of circadian and metabolic genes

PLK1 crucial for proper functioning of cancer cells, researchers reveal

Scientists examine molecular similarities in human and canine B-cell lymphoma

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Researchers discover key role of RAP1 gene in obesity

Stress exposure may be associated with increased risk of aggressive breast cancer

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