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Researchers seek early Alzheimer's detection with MRSI

University of Virginia professor Mathews Jacob has secured a $3.9 million grant to advance his innovative research on detecting Alzheimer's disease in its early stages. Jacob, who specializes in electrical and computer engineering, is teaming up with researchers from the University of Iowa and the University of California-San Francisco to push the boundaries of imaging technology that tracks the brain's metabolic changes - offering a fresh perspective on studying neurodegenerative disorders.

14 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

New insight into the causes of autoimmune diseases

Autoimmune diseases are widespread and notoriously difficult to treat. In part, this is because why the immune system attacks its own tissues in patients with these conditions remains poorly understood.

14 Sep 2024

High-pressure homogenization stabilizes paprika oleoresin

Paprika oleoresin (PO), extracted from chili peppers, is renowned for its vibrant color and beneficial health properties, such as antioxidant and anti-inflammatory effects. However, its lipophilic nature and sensitivity to factors like oxygen, heat, and light restrict its use in water-based foods. While previous approaches, including emulsions and liposomes, have aimed to improve PO's stability, the results have been limited. These persistent challenges underscore the need for new stabilization methods for PO.

14 Sep 2024

New initiative aims to set gold standards for palliative care training

Palliative care aims to improve the quality of life of patients and their families facing problems associated with life-threatening illnesses.

13 Sep 2024

Advanced insulin pump technology improves diabetes management for marathon runners

A series of case reports to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept), describe how a technology giving insulin doses informed by an insulin pump algorithm helped three adults with type 1 diabetes better manage their blood sugars enabling them to lead more active lives, and even run marathons.

13 Sep 2024

ISM2196: A promising AI-developed WRN inhibitor for advanced metastatic cancers

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced the nomination of ISM2196, an AI-driven, potential best-in-class small molecule WRN inhibitor targeting advanced metastatic microsatellite instability (MSI) cancers guided by synthetic lethality strategy.

13 Sep 2024

The first year of Georgia’s Medicaid work requirement is mired in red tape

On a recent summer evening, Raymia Taylor wandered into a recreation center in a historical downtown neighborhood, the only enrollee to attend a nearly two-hour event for people who have signed up for Georgia's experimental Medicaid expansion.

13 Sep 2024

Significant global cardiovascular risk linked to high lipoprotein(a) levels

Review in The Lancet finds that one in five globally are at risk of contracting cardiovascular diseases, because they carry a genetic risk of high levels of a specific lipoprotein, which can be tested for and possibly treated.

12 Sep 2024

New AI imaging technique enhances retinal disorder diagnosis

Population-based studies have shown retinal disorders are the most common cause of irreversible blindness in developed countries and the second most common cause of blindness after cataracts in developing countries.

12 Sep 2024

Study links higher screen time with poorer language skills in young children

Screens have become ubiquitous in our daily lives - which means they've also become part of children's lives too.

12 Sep 2024

New discovery offers hope for overcoming CAR-T cell therapy resistance

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

12 Sep 2024

Early lifestyle changes lead to lasting impacts on metabolism

A new study from the University of Eastern Finland (UEF) uncovers how early lifestyle changes can have long-lasting impacts.

12 Sep 2024

Neuroscientists map brain-wide decision-making process in mice

Neuroscientists have revealed how sensory input is transformed into motor action across multiple brain regions in mice.

12 Sep 2024

New study shows brain waves can be manipulated during REM sleep

Brain waves can be manipulated whilst in rapid eye movement (REM) sleep, a sleep stage associated with memory and cognition, a new study from the University of Surrey finds.

12 Sep 2024

Five key factors identified for predicting immunotherapy response in cancer patients

Immunotherapy has transformed cancer treatment in recent years by enabling the immune system to attack tumor cells.

12 Sep 2024

QB3-led team awarded $12 million to explore autism origins with advanced models

A QB3-led team uniting researchers from the University of California campuses at Berkeley, San Francisco, and Santa Cruz was awarded a $12 million grant from the California Institute for Regenerative Medicine (CIRM) to investigate the origins of autism using sophisticated cellular models called "neural organoids."

12 Sep 2024

New IndiPHARM initiative aims to revolutionize personalized medication management

A Columbia University-led multicenter research effort called IndiPHARM: individual metabolome and exposome assessment for pharmaceutical optimization will develop a platform and monitoring system to prevent unwanted interactions between medications and other environmental, genetic, and lifestyle factors, in order to optimize therapeutic efficacy.

12 Sep 2024

New ultrasound technology provides effective treatment for urinary stones

A noninvasive ultrasound technology called Break Wave™ lithotripsy (BWL) offers a safe and effective new option for treatment of urinary stones, reports a clinical trial in the October issue of The Journal of Urology, an Official Journal of the American Urological Association (AUA).

11 Sep 2024

Ropirio Therapeutics secures exclusive license for novel lymphatic system activators

The Wyss Institute at Harvard University announced today that Ropirio Therapeutics, Inc. (Ropirio) has secured a worldwide, exclusive license from Harvard's Office of Technology Development (OTD) and Boston University (BU)'s Technology Development office for novel molecules that activate the lymphatic system - a first in the pharma industry.

11 Sep 2024