Nucleic Acid News and Research

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Nanotrap particles can improve current sequencing workflows of SARS-CoV-2

New research uses an affinity-based magnetic hydrogel particle enrichment technology (Nanotrap particle enrichment technology) that can concentrate viral particles, leading to improved detection of many viral agents including SARS-CoV-2

14 Dec 2021

Novel breathalyzer relies on viral RNA detection to diagnose SARS-CoV-2

In a new study in The Journal of Molecular Diagnostics, published by Elsevier, investigators report on the design and testing of a breathalyzer, known as the Bubbler, that relies on viral RNA detection to diagnose SARS-CoV-2.

13 Dec 2021

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

A new study reports a method using four PCR tests to distinguish infection with the Omicron variant from that caused by other variants.

12 Dec 2021

Kinetics and persistence of SARS-CoV-2 antibody responses

New study findings indicate that antibody detection shows a distinct pattern depending on the type of antibody detected, the target antigen, the test design, antibody avidity level, and COVID-19 severity.

9 Dec 2021

Interactions between RNA viruses and human RNA-binding proteins

During the virus's attempt to use the host cell to replicate, host proteins interact heavily with the viral genome. Researchers have been investigating these interactions.

8 Dec 2021

An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

A recent review looks at the molecular design of pH-sensitive cationic lipids and their applications for various tissues and cell types.

7 Dec 2021

Study shows COVID booster shots work

A new study investigates uses seven different COVID-19 vaccines as the third dose to boost immunity in vulnerable patients.

6 Dec 2021

Colorimetric detection of SARS-CoV-2 viral RNA by an in vitro transcription/translation assay

This work has emphasized the clinical and translational potential of paper-based biosensors.

6 Dec 2021

Saliva samples show better sensitivity for early stages of COVID-19 detection

Study explores the advantages of saliva compared to MTS and recommends the use of saliva for large-scale screening of COVID-19, especially in pre-symptomatic patients.

6 Dec 2021

Equipment-free handheld microfluidic injection provides visible readout of SARS-CoV-2 detection

In this paper, a group of researchers from Harvard Medical School, McGill University, and Tianjin University describes an on-chip diagnostic technology for the direct detection of SARS-CoV-2 N protein in nasal samples that combines the advantages of hydrodynamic microfluidic filtration and sandwich immunoassay.

5 Dec 2021

Study finds third dose of BNT162b2 or mRNA-1273 is moderately effective against post-vaccination COVID-19 infection

The current study used VHA electronic health records (EHR) to estimate the effectiveness of the booster dose in the USA against post-vaccination COVID-19.

3 Dec 2021

Automate your sample pooling with INTEGRA’s efficient pipetting solutions

INTEGRA’s automated pipetting solutions are helping scientists meet the challenge of efficiently pooling potentially infectious samples prior to testing.

From INTEGRA Biosciences 3 Dec 2021

Special collection of articles highlights China's response to covid-19

Today, The BMJ is launching a special collection of articles on China's response to covid-19 - what it was, how it worked, why traditional public health measures played such a vital role, and how other countries can learn from this experience to protect their populations, in particular in future pandemics.

2 Dec 2021

Impact of engineered ACE2-Fc on SARS-CoV-2 infection

Researchers employ a structure-guided approach for the development of a series of ACE2-Fc variants using human IgG1 or IgG3 backbone.

1 Dec 2021

Plant-derived virus-like particle vaccines against SARS-CoV-2

In a review published in Biotechnology Letters, the authors discuss plant-derived VLP-based vaccines.

1 Dec 2021

Study shows long-term safety and biologic activity of golodirsen in DMD patients

This first-in-human study of golodirsen showed its long-term safety and biologic activity in patients with Duchenne Muscular Dystrophy (DMD). The approved exon-skipping therapy is designed to enable the production of functional dystrophin proteins, as described in the peer-reviewed journal Nucleic Acid Therapeutics.

1 Dec 2021