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Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

A recent study under review at the journal Scientific Reports and currently available on the Research Square* preprint server reported the development of a robust pipeline for fabricating an mRNA vaccine portfolio to combat current and future coronavirus outbreaks, other infectious diseases, and cancer.

19 Oct 2022

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

A vaccine design approach that could protect against new variants of SARS-CoV-2, the virus that causes COVID-19, but also potentially protects against other coronaviruses is one step closer to reality as a result of Penn State College of Medicine research.

18 Oct 2022

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

A pseudovirus system based on deep mutational scanning determines how SARS-CoV-2 mutations can affect its ability to escape neutralization.

18 Oct 2022

SARS-CoV-2 placentitis may cause placental destruction and stillbirth in women not vaccinated for COVID-19

As compared to healthy women, pregnant women infected with SARS-CoV-2 are at a high risk of fatal clinical outcomes.

18 Oct 2022

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

A new study published on the preprint server medRxiv* determines how endothelial activation and inflammation contribute to the formation of microclots in PASC.

18 Oct 2022

CDC expands the use of updated bivalent COVID-19 vaccines to children ages 5 through 11 years

Today, CDC's Director Rochelle P. Walensky, M.D., M.P.H., signed a decision memo expanding the use of updated (bivalent) COVID-19 vaccines to children ages 5 through 11 years.

18 Oct 2022

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

A new study evaluated the current research on incidences of hypertension, new-onset diabetes mellitus, and dyslipidemia as possible sequelae of coronavirus disease 2019 (COVID-19).

18 Oct 2022

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

In a new study, researchers outlined the synthesis and the possible mechanism of action (MOA) of two potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) repurposing drug candidates.

17 Oct 2022

Increased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infection

Researchers explored the association between the expressions of the ACE-2 receptor and TMPRSS2 in the tongue tissue and dysgeusia during SARS-CoV-2 infections.

17 Oct 2022

COVID-19 vaccines show favorable immunogenicity and efficacy in people living with HIV

In a recent study published in the International Journal of Infectious Diseases, researchers assessed the efficacy of coronavirus disease 2019 (COVID-19) vaccines in people living with human immunodeficiency virus (HIV).

16 Oct 2022

A rare case of Hashimoto encephalopathy after COVID vaccination

In a recent ‘Letter to the Editor’ published in the English edition of the journal Neurologandiacute, researchers reported the rare occurrence of Hashimoto encephalopathy in a recipient of the (COVID-19) vaccine Spikevax. Spikevax, research name mRNA-1273, is a COVID-19 vaccine based on the messenger ribonucleic acid (mRNA) technology.

16 Oct 2022

High TNF receptors levels could predict COVID-19 mortality and disease severity

High levels of TNFR might successfully predict the increased severity of COVID-19.

16 Oct 2022

Transition in the management of COVID-19

A review of the current approaches to managing COVID-19, including diagnostic, therapeutic, and preventive measures.

16 Oct 2022

Omicron sublineage BA.2.75.2 largely resistant to several monoclonal antibody antiviral treatments

A study at Karolinska Institutet in Sweden shows that the coronavirus variant BA.2.75.2, an Omicron sublineage, largely evades neutralizing antibodies in the blood and is resistant to several monoclonal antibody antiviral treatments.

14 Oct 2022

Chinese study determines the real-world effectiveness of COVID-19 vaccines

A recent study aimed to determine the real-world effectiveness of COVID-19 vaccines against SARS-CoV-2 infection.

14 Oct 2022

Rapidly fading antibody levels in recovered COVID-19 patients associated with plasma metabolites

A study led by Hong Kong Baptist University (HKBU) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called glycylproline (gly-pro) and its producing enzyme.

14 Oct 2022

Study finds memory B cell clones harbor the capacity to adopt multiple and functionally different fates in COVID-19 patients

Researchers examined single clones of SARS-CoV-2-specific memory B cells to understand their adaptability and fate.

13 Oct 2022

Researchers develop an HERV-enveloped recombinant baculoviral DNA vaccine against SARS-CoV-2

Researchers developed a human endogenous retrovirus (HERV)-enveloped recombinant baculoviral DNA vaccine to target the SARS-CoV-2 Delta variant, and tested its cross-protection efficacy using mice models.

13 Oct 2022

Spike Protein News and Research

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

Adaptation-proof SARS-CoV-2 vaccine design is one step closer to reality

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

SARS-CoV-2 placentitis may cause placental destruction and stillbirth in women not vaccinated for COVID-19

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

CDC expands the use of updated bivalent COVID-19 vaccines to children ages 5 through 11 years

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

Increased TMPRSS2 expression in tongue tissue of females and alcohol drinkers identified as a potential risk factor for SARS-CoV-2 infection

COVID-19 vaccines show favorable immunogenicity and efficacy in people living with HIV

A rare case of Hashimoto encephalopathy after COVID vaccination

High TNF receptors levels could predict COVID-19 mortality and disease severity

Transition in the management of COVID-19

Omicron sublineage BA.2.75.2 largely resistant to several monoclonal antibody antiviral treatments

Chinese study determines the real-world effectiveness of COVID-19 vaccines

Rapidly fading antibody levels in recovered COVID-19 patients associated with plasma metabolites

Study finds memory B cell clones harbor the capacity to adopt multiple and functionally different fates in COVID-19 patients

Researchers develop an HERV-enveloped recombinant baculoviral DNA vaccine against SARS-CoV-2

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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