Clinical Trial News and Research

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Treatment with whole plant medicinal cannabis reduces epileptic seizure frequency in children

Epileptic seizure frequency fell by an average of 86% among 10 children treated with whole plant medicinal cannabis, reveals a case series, published in the open access journal BMJ Paediatrics Open.

15 Dec 2021

Hyperbaric oxygen treatment quickly resolves severe breathing difficulties in COVID-19 patients

High pressure (hyperbaric) oxygen resolves severe breathing difficulties in COVID-19 patients much more quickly than standard therapy, taking an average of 3 rather than 9 days, reveal the results of a small comparative clinical trial published online in Emergency Medicine Journal.

15 Dec 2021

Medical AI and radiologist experts may be vulnerable to adversarial attacks

Artificial intelligence (AI) models that evaluate medical images have potential to speed up and improve accuracy of cancer diagnoses, but they may also be vulnerable to cyberattacks.

14 Dec 2021

Duke Human Vaccine Institute secures federal contract for advancing investigational vaccines

The National Institute of Allergy and Infectious Diseases awarded researchers at the Duke Human Vaccine Institute a contract that enables it to compete for projects advancing investigational vaccines to production for use in early clinical trials.

14 Dec 2021

Trial in sub-Saharan Africa evaluates the efficacy of COVID-19 vaccine in people living with HIV

A highly anticipated clinical trial in eight sub-Saharan countries is the first to specifically evaluate the efficacy of a COVID-19 vaccine in people living with HIV, including those with poorly controlled infections.

13 Dec 2021

Lymphoma patients can benefit from early CAR T treatment, study shows

Chimeric antigen receptor T-cell therapy or CAR T is a breakthrough treatment for patients with certain types of blood cancers.

13 Dec 2021

Henry Ford surgeons use unique approach to perform first precision prostatectomy

Surgeons at Henry Ford Health System's Vattikuti Urology Institute performed what is believed to be the first precision prostatectomy through the bladder using a single port robotic surgical system.

13 Dec 2021

Study offers new hope for large B-cell lymphoma patients

Of the 18,000 people diagnosed with large B-cell lymphoma each year, only half will be successfully treated with chemotherapy. The 9,000 remaining patients typically have poor outcomes, with only 25% responding to additional, higher-intensity chemotherapy, followed by a stem cell transplant.

13 Dec 2021

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

The combination of dasatinib, blinatumomab, and prednisone can be effective in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are not good candidates for intensive chemotherapy treatment.

13 Dec 2021

Novel assay using finger-prick samples provides COVID-19 vaccine efficacy data

Researchers estimate vaccine efficacy over a period post-vaccination using quantitative antibody assay on finger-prick blood samples.

13 Dec 2021

MV130 immunotherapy boosts natural and vaccine-induced SARS-CoV-2 immunity in mice

A new mouse study found that intranasal administration of MV130 protected against severe acute respiratory syndrome coronavirus 2.

13 Dec 2021

Fully vaccinated contacts of a COVID-19 case should take daily rapid tests for 7 days

From Tuesday 14 December, people who are fully vaccinated and identified as a contact of someone with COVID-19 - whether Omicron or not - should take an NHS rapid lateral flow test every day for 7 days to help slow the spread of COVID-19.

12 Dec 2021

Novel immunotherapy shows promise for children, young adults with recurrent AML

An immunotherapy harnessing the immune system's "natural killer" cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return.

12 Dec 2021

Statistical models predict outcomes for patients receiving non-intensive AML therapy

An international team has developed statistical models to predict the risk of early death in patients being treated with non-intensive therapies for acute myeloid leukemia (AML).

12 Dec 2021

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial.

12 Dec 2021

Rare population of toxic senescent cells in the brain could be a target for Alzheimer's treatment

For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer's disease treatment.

11 Dec 2021

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.

11 Dec 2021

NRG Oncology CC004 trial: Bupropion does not improve sexual desire for female cancer survivors

Despite preliminary supporting evidence that the dopaminergic agent bupropion might improve sexual desire for female cancer survivors, the NRG Oncology CC004 clinical trial determined that bupropion did not improve outcomes when compared to a placebo.

10 Dec 2021

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

A University of Florida Health researcher has successfully analyzed the many mutations in the omicron variant of the SARS-CoV-2 virus, a crucial step in better understanding the variant's potential threat and ways to combat it.

9 Dec 2021

Online single-session interventions help curb teen depression, study shows

A study of more than 2,400 adolescents ages 13 to 16 shows two online, single-session interventions designed to help curb teen depression works, a tool very much needed given a rise in teen depression and loss of some in-person mental health services during the Covid-19 pandemic.

9 Dec 2021

Clinical Trial News and Research

Treatment with whole plant medicinal cannabis reduces epileptic seizure frequency in children

Hyperbaric oxygen treatment quickly resolves severe breathing difficulties in COVID-19 patients

Medical AI and radiologist experts may be vulnerable to adversarial attacks

Duke Human Vaccine Institute secures federal contract for advancing investigational vaccines

Trial in sub-Saharan Africa evaluates the efficacy of COVID-19 vaccine in people living with HIV

Lymphoma patients can benefit from early CAR T treatment, study shows

Henry Ford surgeons use unique approach to perform first precision prostatectomy

Study offers new hope for large B-cell lymphoma patients

Drug combination without chemotherapy can be effective in treating older patients with Ph+ ALL

Novel assay using finger-prick samples provides COVID-19 vaccine efficacy data

MV130 immunotherapy boosts natural and vaccine-induced SARS-CoV-2 immunity in mice

Fully vaccinated contacts of a COVID-19 case should take daily rapid tests for 7 days

Novel immunotherapy shows promise for children, young adults with recurrent AML

Statistical models predict outcomes for patients receiving non-intensive AML therapy

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Rare population of toxic senescent cells in the brain could be a target for Alzheimer's treatment

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

NRG Oncology CC004 trial: Bupropion does not improve sexual desire for female cancer survivors

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

Online single-session interventions help curb teen depression, study shows

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