Genomic News and Research

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Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

In what is believed to be the most comprehensive molecular characterization to date of the most common - and often treatment-resistant - form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them.

From Johns Hopkins Medicine 31 Oct 2019

Novel, cost-effective method successfully identifies aggressive tumors

Researchers have developed a novel, cost-effective genomic method that can identify highly heterogenous tumors that are typically aggressive in nature.

30 Oct 2019

DNA sequences encode information in many different ways

DNA sequences encode information in many different ways. Codons specify the amino acids involved in making a protein.

30 Oct 2019

Polygenic scoring system shows promise to predict depression risk and resilience under stress

Depression doesn't come from one gene, one life event, or one personality trait. That's what makes it so hard to predict, prevent or treat effectively.

29 Oct 2019

Researchers develop new genomic analysis method for identifying Yersinia strains

The Yersinia genus covers a vast range of bacteria that are distinguished by criteria such as whether or not they are able to cause disease (their pathogenicity).

29 Oct 2019

Study uses whole-genome sequencing for early identification and containment of AMR pathogens

A study published today in PNAS examines the evolutionary and epidemiologic history of an epidemic strain of extensively drug-resistant tuberculosis (XDR-TB) - called LAM4/KZN- in KwaZulu-Natal, South Africa.

29 Oct 2019

Researchers reconstruct the evolutionary history of metabolism

By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks - which drive every cellular process from protein building to DNA repair - became less random, more modular and more hierarchical over time, the researchers say.

29 Oct 2019

How the SETD1A gene produces schizophrenia in mice

A new study published in the journal Neuron on October 9, 2019 reports that scientists have unlocked part of the secrets of the SETD1A gene – how mutations in the gene put the individual at risk for the condition.

26 Oct 2019

Scientists pinpoint epigenetic differences in the way lupus affects black women

Scientists at the HudsonAlpha Institute for Biotechnology have pinpointed epigenetic differences in the way lupus affects black women compared to other lupus patients, revealing important mechanics of the puzzling disease.

24 Oct 2019

Gene linked to schizophrenia likely confers risk for illness

Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in schizophrenia patients.

24 Oct 2019

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Sarcomas - cancers that arise from transformed mesenchymal cells (a type of connective tissue) - are quite deadly. Gastrointestinal stromal tumors are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

24 Oct 2019

Researchers receive $3.2 million NIH grant to pursue a deeper understanding of Down syndrome

Mount Sinai researchers have been awarded a $3.2 million grant from the National Institutes of Health to pursue a deeper understanding of Down syndrome, the most common genetic cause of intellectual and developmental disabilities in children and young adults, affecting more than 200,000 individuals in the United States.

22 Oct 2019

Antibiotic treatment can cause transient and long-term disruption of gut microbes

Trillions of microbes in the intestine aid human health, including digestion of breast milk, breaking down fiber and helping control the immune system.

22 Oct 2019

Dual action of genes and RNA influences aggressive triple-negative breast cancer

Women with an aggressive, less-common type of breast cancer, known as triple-negative, versus a more common form of the disease, could be differentiated from each other by a panel of 17 small RNA molecules that are directly influenced by genetic alterations typically found in cancer cells.

22 Oct 2019

Salk Institute scientists receive NIH grant to better understand the brain

Salk Institute scientists Nicola Allen, Eiman Azim, Margarita Behrens, and Joseph Ecker have been named recipients in the 2019 round of grants from the National Institutes of Health (NIH) to better understand the brain.

21 Oct 2019

Link found between genetic variations and size of the brainstem, other subcortical structures

Researchers have found a link between 48 common genetic variations and the size of the brainstem and other subcortical structures deep within the brain.

21 Oct 2019

NCATS funds 'All of Us Research Program' to evaluate innovative DNA sequencing tools

The All of Us Research Program has selected the HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, to evaluate the use of leading-edge DNA sequencing technologies that could someday improve diagnosis and treatment of many diseases, both common and rare.

18 Oct 2019

Development and assessment of NGS-based microsatellite instability assay

The assay has a clinically relevant five-day turnaround time and can be conducted on as little as 20 ng genomic DNA with a batch size of up to forty samples in a single run.

18 Oct 2019

Researchers develop new cheap method to identify aggressive tumors

Researchers at Karolinska Institutet in Sweden have developed a new cheap method that can identify highly heterogeneous tumors that tend to be very aggressive, and therefore need to be treated more aggressively. The technique is presented in the scientific journal Nature Communications.

18 Oct 2019

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Researchers at the Johns Hopkins Kimmel Cancer Center report that their study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1

From Johns Hopkins Medicine 18 Oct 2019

Genomic News and Research

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

Novel, cost-effective method successfully identifies aggressive tumors

DNA sequences encode information in many different ways

Polygenic scoring system shows promise to predict depression risk and resilience under stress

Researchers develop new genomic analysis method for identifying Yersinia strains

Study uses whole-genome sequencing for early identification and containment of AMR pathogens

Researchers reconstruct the evolutionary history of metabolism

How the SETD1A gene produces schizophrenia in mice

Scientists pinpoint epigenetic differences in the way lupus affects black women

Gene linked to schizophrenia likely confers risk for illness

Study reveals novel druggable driver gene in human gastrointestinal stromal tumors

Researchers receive $3.2 million NIH grant to pursue a deeper understanding of Down syndrome

Antibiotic treatment can cause transient and long-term disruption of gut microbes

Dual action of genes and RNA influences aggressive triple-negative breast cancer

Salk Institute scientists receive NIH grant to better understand the brain

Link found between genetic variations and size of the brainstem, other subcortical structures

NCATS funds 'All of Us Research Program' to evaluate innovative DNA sequencing tools

Development and assessment of NGS-based microsatellite instability assay

Researchers develop new cheap method to identify aggressive tumors

Researchers uncover novel molecular clues for tumor aggression in neurofibromatosis type 1

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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