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Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer's disease, and advance disease.

19 Apr 2021

Gene therapy for common forms of congenital blindness shows promise to improve vision

A new gene therapy for one of the most common forms of congenital blindness was safe and improved patients' vision, according to initial data from a clinical trial led by researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania.

19 Apr 2021

Mirati to contribute $4 million grant to support SU2C research on KRAS mutant cancers

Stand Up To Cancer and Mirati Therapeutics Inc. - a late-stage targeted oncology company - today announced that Mirati will contribute a $4 million grant to SU2C to develop new approaches to treat patients with KRAS mutant cancers, as a part of the SU2C Catalyst program.

19 Apr 2021

Phico Therapeutics awarded up to $18.2 million USD (c.£13.2 million GBP) CARB-X funding to advance SASPject antibacterial therapy through Phase 1 clinical trials

Phico Therapeutics has been awarded a grant of up to $18.2 million USD to tackle the global rising threat of drug-resistant bacteria.

From Phico Therapeutics 19 Apr 2021

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

Researchers in the United States have developed an alternative messenger RNA (mRNA) delivery platform to the lipid nanoparticles that are currently used in vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Apr 2021

FDA revokes EUA for monoclonal antibody therapy bamlanivimab to treat patients with COVID-19

Today, the U.S. Food and Drug Administration revoked the emergency use authorization (EUA) that allowed for the investigational monoclonal antibody therapy bamlanivimab, when administered alone, to be used for the treatment of mild-to-moderate COVID-19 in adults and certain pediatric patients.

17 Apr 2021

Novel CRISPR-based technology may lead to powerful epigenetic therapies

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

17 Apr 2021

Three teams selected to receive the first awards from Dartmouth Innovations Accelerator for Cancer

Three teams of Dartmouth researchers have been selected to receive the first awards from the Dartmouth Innovations Accelerator for Cancer.

17 Apr 2021

Study sheds light on how autism manifests in the brains of girls

New research has shed light on how autism-spectrum disorder (ASD) manifests in the brains of girls, prompting the scientists to warn that conclusions drawn from studies conducted primarily in boys should not be assumed to hold true for girls.

16 Apr 2021

Curcumin nanosystems could be powerful COVID-19 therapeutics

With new variants of SARS-CoV-2 emerging, the COVID-19 pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanosystems to treat COVID-19.

16 Apr 2021

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Researchers from the University of Liverpool have shown the potential of repurposing an existing and cheap drug into a long-acting injectable therapy that could be used to treat Covid-19.

16 Apr 2021

Bristol-based new biotech company is developing ground-breaking treatments for Covid-19

A team of top scientists from the University of Bristol have announced the formation of a new biotech company that is developing ground-breaking and newly patented potential treatments for Coronavirus.

16 Apr 2021

Recovered COVID-19 patients may need only a single vaccine dose, suggests study

People who have recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but little immune benefit after the second dose, according to new research from the Penn Institute of Immunology. The findings, published today in Science Immunology, suggest only a single vaccine dose may be needed to produce a sufficient antibody response.

16 Apr 2021

Breast cancer treatment can be safely reduced in women over the age of 70

Oncologists faced with treating older women with breast cancer often must decide if the treatment may be more detrimental than the cancer.

16 Apr 2021

Feline model of SARS-CoV-2 infection imitates COVID-19 in humans

Researchers in the United States have validated a feline model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that closely imitates coronavirus disease 2019 (COVID-19) in humans.

15 Apr 2021

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Researchers from Kumamoto University have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis.

15 Apr 2021

Heart Research UK funds new project investigating the effects of COVID-19 on blood vessels and blood pressure

A project at the University of Glasgow that is aiming to better understand the effects that COVID-19 infection has on blood vessels and blood pressure has received a grant of £250,000 from national charity Heart Research UK.

15 Apr 2021

Study may lead to new treatment for incurable brain cancer in children

Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 20 children in Australia each year, DIPG is a devastating disease with an average survival time of just nine months after diagnosis.

15 Apr 2021

Experts to discuss advanced cancer cell and gene therapies at Summit 2021

April 29 marks a pivotal moment in cancer research when the world's brightest minds come together to discuss how to translate the success of CAR T-cell therapies for blood cancers into successful cell and gene therapies for the most complex and deadly solid tumor cancers.

15 Apr 2021

Study sheds light on reduced neutralization of SARS-CoV-2 variants of concern

Researchers in the United States have predicted the binding epitopes of uncharacterized neutralizing antibodies that target the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

14 Apr 2021

Therapeutics News and Research

Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

Gene therapy for common forms of congenital blindness shows promise to improve vision

Mirati to contribute $4 million grant to support SU2C research on KRAS mutant cancers

Phico Therapeutics awarded up to $18.2 million USD (c.£13.2 million GBP) CARB-X funding to advance SASPject antibacterial therapy through Phase 1 clinical trials

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines

FDA revokes EUA for monoclonal antibody therapy bamlanivimab to treat patients with COVID-19

Novel CRISPR-based technology may lead to powerful epigenetic therapies

Three teams selected to receive the first awards from Dartmouth Innovations Accelerator for Cancer

Study sheds light on how autism manifests in the brains of girls

Curcumin nanosystems could be powerful COVID-19 therapeutics

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Bristol-based new biotech company is developing ground-breaking treatments for Covid-19

Recovered COVID-19 patients may need only a single vaccine dose, suggests study

Breast cancer treatment can be safely reduced in women over the age of 70

Feline model of SARS-CoV-2 infection imitates COVID-19 in humans

Anti-diabetic drug metformin inhibits disease progression in Alport syndrome mouse model

Heart Research UK funds new project investigating the effects of COVID-19 on blood vessels and blood pressure

Study may lead to new treatment for incurable brain cancer in children

Experts to discuss advanced cancer cell and gene therapies at Summit 2021

Study sheds light on reduced neutralization of SARS-CoV-2 variants of concern

Next-generation therapeutics eBook eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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