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Implications of dosing sparing and booster shots in the context of prior SARS-CoV-2 infection

The current study suggests that deferring the second vaccination of individuals with prior infection may be a cost-effective strategy.

21 Sep 2021

Study paves the way for development of novel delivery systems to suppress HIV

In a new study supported by the National Institutes of Health, researchers used exosomes, tiny nanoparticles capable of being taken up by cells, to deliver novel protein into the cells of mice infected with HIV. The protein attached to HIVs' genetic material and prevented it from replicating, resulting in reduced levels of HIV in the bone marrow, spleen, and brain.

21 Sep 2021

Scientists hypothesize SARS-CoV-2 cryptically circulating among humans before the current outbreak

As nations begin to recover, researchers from the National Taiwan University and Academia Sinica in Taipei have been looking to identify the changes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent over the course of the pandemic in order to better understand why the disease showed such virulence.

20 Sep 2021

Differences in DNA methylation could accurately predict progression of liver disease

Findings of a national study led by the Translational Genomics Research Institute, an affiliate of City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease.

20 Sep 2021

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

In a recent study, researchers study the molecular aspects of SARS-CoV-2 host cell entry and inhibition of host-specific cellular mechanisms.

20 Sep 2021

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

A large international collaboration led by researchers from the Johns Hopkins Kimmel Cancer Center has identified promising new targets for pancreatic cancer treatment and early diagnosis after examining various aspects of these tumors' genes and proteins.

20 Sep 2021

Atopic dermatitis may stem from poorly regulated sex hormones, study suggests

A study led by UT Southwestern dermatologists suggests that a common inflammatory skin condition may stem from poorly regulated sex hormones.

20 Sep 2021

What impact has SARS-CoV-2 variant B.1.1.519 had on Mexico City?

The current study reports the effective reproduction number of B.1.1.519 and presents its geographical origin based on phylogenetic analysis.

20 Sep 2021

Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

Researchers from the University of Southern California investigated mutations in the N-terminal and RBD domains of the spike protein.

20 Sep 2021

Characterizing the flexibility of SARS-CoV-2 variant of concern spike proteins

A novel protein modeling method assesses changes to the conformation of the SARS-CoV-2 spike protein that have been encountered by mutation.

19 Sep 2021

Analysis of 2021 Ebola outbreak reveals long-term dormant infections

Guinea recently experienced its second outbreak of the Ebola virus disease within the last decade.

19 Sep 2021

A variant analysis approach for SARS-CoV-2 in wastewater samples

A recent study proposes a simple and specific method for the enhanced detection of the SARS-CoV-2 VOCs in wastewater samples.

19 Sep 2021

Researcher explores the genetic interplay between personality traits and COVID

In a recent study, scientists aimed to find the genetic effects that the coronavirus disease 2019 (COVID-19) has on individuals with psychiatric disorders.

19 Sep 2021

Researchers report on under-sequenced region of S gene of the SARS-CoV2 Delta variant

In a recent study, Swiss researchers use improved techniques to understand the biological significance behind the Delta variant.

19 Sep 2021

Study uncovers five new genetic loci predisposing to atopic dermatitis

An international study led by the University of Oulu's researchers reports five new genetic loci predisposing to atopic dermatitis.

18 Sep 2021

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

A new study describes a small molecule referred to as RG10 that may have potent antiviral activity against SARS-CoV-2 in human cells.

16 Sep 2021

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

In a study published on the preprint server medRxiv*, scientists studying the SARS-CoV-2 genome have identified a region linked with the disease severity.

16 Sep 2021

Researchers identify key factor responsible for brain development during evolution

As humans, we have a large and intricately folded neocortex that accounts for many of our intellectual abilities and sets us apart from all other species

16 Sep 2021

UTHSC researcher receives funding to advance The Cancer Genome Atlas project

Neil Hayes, MD, MPH, director of the Center for Cancer Research at the University of Tennessee Health Science Center, is one of two principal investigators for a $1.8 million grant that extends the work of The Cancer Genome Atlas (TCGA), a groundbreaking multisite project to understand cancer at its molecular level through genome sequencing and extensive data analysis.

16 Sep 2021

Study looks at drug resistance in BRAF-mutated gliomas

Looking to understand why some brain tumors with a specific mutation can start to reject drugs commonly used to treat them, CU Cancer Center member Jean Mulcahy Levy, MD, led researchers from institutions around the country - including several from the University of Colorado School of Medicine - to study samples of brain tumors before and after being treated with the drug.

16 Sep 2021

Genome News and Research

Implications of dosing sparing and booster shots in the context of prior SARS-CoV-2 infection

Study paves the way for development of novel delivery systems to suppress HIV

Scientists hypothesize SARS-CoV-2 cryptically circulating among humans before the current outbreak

Differences in DNA methylation could accurately predict progression of liver disease

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

Atopic dermatitis may stem from poorly regulated sex hormones, study suggests

What impact has SARS-CoV-2 variant B.1.1.519 had on Mexico City?

Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

Characterizing the flexibility of SARS-CoV-2 variant of concern spike proteins

Analysis of 2021 Ebola outbreak reveals long-term dormant infections

A variant analysis approach for SARS-CoV-2 in wastewater samples

Researcher explores the genetic interplay between personality traits and COVID

Researchers report on under-sequenced region of S gene of the SARS-CoV2 Delta variant

Study uncovers five new genetic loci predisposing to atopic dermatitis

Antiviral compound RG10 acts via intracellular SARS-CoV-2-ER dynamics

CXCR6/CXCL16 axis has significant role in the immuno-pathogenesis of severe COVID-19

Researchers identify key factor responsible for brain development during evolution

UTHSC researcher receives funding to advance The Cancer Genome Atlas project

Study looks at drug resistance in BRAF-mutated gliomas

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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