Genomic News and Research

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New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

A new measurement standard developed by the National Institute of Standards of Technology has been used successfully by the Frederick National Laboratory for Cancer Research to check the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer.

18 Aug 2016

New research article reveals global patterns of genetic variation

Published in today's edition of Nature, the research led by Dr Monkol Lek of the University of Sydney and Dr Daniel MacArthur of The Broad Institute of MIT and Harvard Universities reveals patterns of genetic variation worldwide by sequencing the exomes of 60,706 individuals with diverse geographic ancestries, including European, African, South Asian, East Asian and Latino populations.

18 Aug 2016

Schizophrenia vulnerability emerged after divergence of modern humans from Neanderthals

Schizophrenia poses an evolutionary enigma. The disorder has existed throughout recorded human history and persists despite its severe effects on thought and behavior, and its reduced rates of producing offspring.

17 Aug 2016

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

16 Aug 2016

New study uncovers how chromosomal changes impact tumor formation and growth

As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

16 Aug 2016

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Researchers from the University Health Network's Department of Anesthesia and Pain Management and the Institute for Clinical Evaluative Sciences have determined that patients who have not had an opioid prescription within a year prior to their procedure are at low risk of developing persistent opioid use after major surgery.

11 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition.

11 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Experts propose new clinical guidelines for diagnosing FASD

A group of experts on fetal alcohol spectrum disorders, organized by the National Institute on Alcohol Abuse and Alcoholism, has produced proposed clinical guidelines for diagnosing FASD, which can result when a mother drinks during pregnancy.

11 Aug 2016

Researchers develop computational algorithm to analyze big genomic data for different cancers

University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze "Big Data" obtained from tumor samples to better understand and treat cancer.

10 Aug 2016

Experts develop new genomic testing method for pulmonary hypertension caused by genetic mutation

Pulmonology and genetics experts from two Utah healthcare organizations have collaboratively developed a new diagnostic genomic testing method for a rare form of pulmonary hypertension caused by a genetic mutation they discovered three years ago.

9 Aug 2016

UTA researcher to design computing tools to analyze large, complex patient data

A UTA researcher is developing computing tools that will employ multiple methods of accessing and analyzing very large, complex patient data.

9 Aug 2016

New Sequins technology could help improve quality of genomic analysis

Australian genomics researchers have announced the development of Sequins -- synthetic 'mirror' DNA sequences that reflect the human genome.

9 Aug 2016

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

Cancer Treatment Centers of America at Western Regional Medical Center has dosed its first three patients as part of the launch of a Phase I clinical trial using a novel antibody to treat patients with advanced solid tumors.

8 Aug 2016

Scientists make major advance in understanding how stem cells become specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse.

5 Aug 2016

Customizing weight management program for individual personalities may increase success rates

Adapting a weight management program to the client's personality may help improve success rates, according to South Dakota State University health and nutritional sciences researcher Lacey McCormack.

5 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

Watch-and-wait approach means some patients could delay taking highly toxic non-curative anticancer drugs that come with substantial side effects

4 Aug 2016

Scientists engineer therapeutic system with two arms to get better hold on cancer target

Scientists have engineered a sort of biological barbell that can get inside cancer cells and do damage to two proteins that work independently and together to enable cancer's survival and spread.

3 Aug 2016

Genomic News and Research

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

New research article reveals global patterns of genetic variation

Schizophrenia vulnerability emerged after divergence of modern humans from Neanderthals

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

New study uncovers how chromosomal changes impact tumor formation and growth

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Novel computational analysis of prostate cancer suggests potential targets for therapy

Experts propose new clinical guidelines for diagnosing FASD

Researchers develop computational algorithm to analyze big genomic data for different cancers

Experts develop new genomic testing method for pulmonary hypertension caused by genetic mutation

UTA researcher to design computing tools to analyze large, complex patient data

New Sequins technology could help improve quality of genomic analysis

CTCA at Western begins clinical trial for novel antibody to treat patients with advanced tumors

Scientists make major advance in understanding how stem cells become specialized

Customizing weight management program for individual personalities may increase success rates

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

Watch-and-wait approach may prove successful in subset of adults with advanced kidney cancer

Scientists engineer therapeutic system with two arms to get better hold on cancer target

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