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Discovery 'significant step' in understanding leukaemia drug resistance

Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation.

8 Jun 2009

Johnson & Johnson's research reflecting new Washington policies

Health care supplier Johnson & Johnson will focus on new treatments and improved tests for cancer and other diseases for which company perceives unmet needs, like diabetes, hepatitis C, and HIV, as well as using new, Washington-supported research techniques to gauge their effectiveness, researchers and executives said at a briefing with analysts, BusinessWeek reports.

5 Jun 2009

With shrinking budgets, states cutting health services

As state revenues continue their downturn due to the recession, 16 states are trying to find ways to deal with increased health care costs, The New York Times reports: "The carnage in state budgets is getting worse, a report said Thursday, with places like Arizona being hurt by falling revenue on multiple fronts, like personal income and sales taxes. Other states are having mixed experiences, with some tax categories stable, or even rising, even as others fall off the map."

5 Jun 2009

Drug-resistant tuberculosis a very real threat in the Pacific region

Health officials in the Pacific are concerned about two new strains of tuberculosis - multi drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) - both strains have been found to be resistant to the two most powerful drugs that have been used to treat tuberculosis (TB) for the past five decades.

5 Jun 2009

Experimental drug five times more effective against MDR-TB than conventional therapy

A Johnson & Johnson-run study found that its experimental drug TMC207 could make conventional tuberculosis treatment five times more effective against multi-drug resistant TB (MDR-TB) because it cleared traces of the TB bacteria in the sputum of 48 percent of study volunteers after eight weeks, Reuters reports (Emery, Reuters, 6/3). The results were published on Wednesday in the New England Journal of Medicine.

4 Jun 2009

Rhes protein responsible for brain cell damage in Huntington disease

Johns Hopkins brain scientists have figured out why a faulty protein accumulates in cells everywhere in the bodies of people with Huntington's disease (HD), but only kills cells in the part of the brain that controls movement, causing negligible damage to tissues elsewhere.

4 Jun 2009

Drug derived from the hydrangea root shows promise for autoimmune disorders

A drug derived from the hydrangea root, used for centuries in traditional Chinese medicine, shows promise in treating autoimmune disorders, report researchers from the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children's Hospital Boston (PCMM/IDI), along with the Harvard School of Dental Medicine.

4 Jun 2009

Discovery of critical marker of response to gemcitabine in pancreatic cancer

A protein related to aggressive cancers can actually improve the efficacy of gemcitabine at treating pancreatic cancer, according to a Priority Report in Cancer Research, published by researchers at Thomas Jefferson University.

4 Jun 2009

Discovery of two proteins may lead to more effective treatment of endocarditis and infections associated with implants

A research team at the Faculty of Odontology at Malmö University in Sweden has discovered two new proteins that are of importance to the survival of bacteria and their colonization of the human body. Besides enhancing our knowledge of the ability of bacteria to spread, the findings may also lead to more effective treatment of endocarditis and infections associated with implants.

4 Jun 2009

Stopping fatty change in heart cells

Heart failure is one of the world's most frequent causes of death - caused by conditions such as diabetes and obesity. With people who are overweight, the heart has to do more work in order to pump the blood through the circulatory system and this causes an increase in blood pressure.

4 Jun 2009

FDA moves towards greater openness

The Associated Press reports that FDA Commissioner Margaret Hamburg "announced Tuesday she has created a task force to make recommendations on how the agency can release more information in such areas as drug evaluation and enforcement matters. She wants a report in six months."

3 Jun 2009

WHO closer to declaring H1N1 flu outbreak a pandemic

The WHO on Tuesday said it was "getting closer" to declaring the H1N1 (swine) flu outbreak to be a pandemic, as the virus continues to spread to people outside of North America, and in populations "as far apart as Britain, Spain, Japan, Chile and Australia," the AP/Washington Post reports (Jordans, AP/Washington Post, 6/2).

3 Jun 2009

Research looks at relationship between death rates from lung cancer and how much a person smoked

It's common knowledge that smoking raises risks of lung cancer. And yet researchers haven't known whether continued smoking by lung cancer patients would increase the risk of the cancer's spread.

3 Jun 2009

Soap-sniffing sensors that monitor health-care workers' hand hygiene by detecting sanitizer or soap fumes

Call it a breathalyzer for the hands. Using sensors capable of detecting drugs in breath, new technology developed at University of Florida monitors health-care workers' hand hygiene by detecting sanitizer or soap fumes given off from their hands.

3 Jun 2009

Scientists uncover mode of action of enzyme linked with several types of cancer

Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication.

3 Jun 2009

Skin cells provide new knowledge about brain functions

Until now diseases like schizophrenia and bipolar disorder have been difficult to study biologically, since this would entail taking samples from the patient's brain.

3 Jun 2009

British researchers call for WHO to 'condemn homeopathy' for serious diseases

British researchers on Monday requested the WHO "publicly condemn homeopathy as a treatment for serious diseases, such as HIV/AIDS, TB and malaria," amid growing concern that some patients are dying as a result of choosing homeopathy over effective medicines, the Mail & Guardian reports. "The WHO works with national organisations that promote homeopathy and other alternative medicines in their public health programmes," according to the Mail & Guardian.

2 Jun 2009

Universal access to malaria drugs, prevention by 2013 will lead to eradication, Nigerian Government says

The Nigerian government believes that by 2013 malaria will cease to be a major public health problem in the country because families will have universal access to prevention and treatment, which will ultimately lead to malaria eradication in Nigeria, according to a document prepared by the National Malaria Control Program of the Federal Ministry of Health in Abuja, Nigeria, Xinhua reports.

2 Jun 2009

Arizona jail could be ‘e-health’ test, but slow to take necessary steps

A troubled county jail, where hundreds of lawsuits have stemmed from mistakes in managing the inmates' health information, would be a perfect testing ground for electronic medical records, the Arizona Republic reports.

2 Jun 2009

Discovery of new arenavirus associated with hemorrhagic fever – first identified in nearly four decades

Scientists at Columbia University's Mailman School of Public Health, the South African National Institute for Communicable Diseases of National Health Laboratory Service (NICD-NHLS), the U.S. Centers for Disease Control and Prevention, and Roche's 454 Life Sciences Corporation have discovered the new virus responsible for a highly fatal hemorrhagic fever outbreak in Zambia and South Africa in late 2008.

2 Jun 2009