Therapeutics News and Research

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Study suggests T-cells don't determine survival in severe COVID-19

In the study, which appeared on the pre-print server medRxiv, the team found that when the monkeys were reinfected, the T cell-depleted animals showed anamnestic immune responses, the enhanced reaction of the body's immune system to an antigen that is related to an antigen previously encountered.

6 Apr 2021

Researchers to test a promising treatment for high-risk COVID-19 outpatients

The nation has been coping with the pandemic for more than a year, and in this time, researchers have learned a great deal about how to treat COVID-19.

6 Apr 2021

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce.

5 Apr 2021

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

A unique vaccine to protect against COVID-19 begins clinical testing Tuesday, 6 April, at the Walter Reed Army Institute of Research (WRAIR), part of the U.S. Army Medical Research and Development Command.

5 Apr 2021

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells.

3 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Research finds possible explanation for why many cancer drugs don't work in human trials

A possible explanation for why many cancer drugs that kill tumor cells in mouse models won't work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.

1 Apr 2021

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.

1 Apr 2021

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye.

1 Apr 2021

Study sheds new light on the role of oxygen deprivation in cancer development

A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development.

1 Apr 2021

Objectives, challenges and opportunities of new IASLC Molecular Database Project

A new Molecular Database Project initiated by the International Association for the Study of Lung will accelerate the understanding of lung cancer biology, clinical care and care delivery on a global scale and will improve the prognosis and optimal treatment of lung cancer across time and space, according to an editorial in the Journal of Thoracic Oncology, an official journal of the IASLC.

31 Mar 2021

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

Research led by Michigan Medicine's Scleroderma Program and published in Arthritis & Rheumatology found that tocilizumab, a FDA-approved anti-inflammatory drug used to combat rheumatoid arthritis, can prevent lung disease in patients with systemic sclerosis if detected early enough in the disease course.

31 Mar 2021

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

A team of researchers recently discussed the potential role of a new assay in bridging a major gap in SARS-CoV-2 research. This assay can throw light on 1) the selection of complementary monoclonal antibody candidates and 2) rapid identification of the immune escape to emerging RBD variants following vaccination or natural infection.

31 Mar 2021

Combination of two existing drugs can kill cancer cells

Preclinical research from VCU Massey Cancer Center published recently in the Proceedings of the National Academy of Sciences shows that the combination of two existing drugs can exploit the metabolic "hunger" of a particularly aggressive type of neuroblastoma to kill cancer cells without inflicting too much collateral damage to healthy tissue.

31 Mar 2021

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat, since its causes have not yet been adequately researched.

30 Mar 2021

Researchers develop novel test that screens for SARS-CoV-2 variants of concern

A team of scientists from the United States has recently developed a single-tube duplex molecular assay for rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants containing E484K and N501Y spike mutations.

30 Mar 2021

SwiftScale Biologics: Cell-Free Synthesis of Biologics

In this interview, News-Medical talks to David Mace, CEO at SwiftScale Biologics, about the work they do in cell-free synthesis, their partnership with Sartorius and the biologics field as a whole.

From Sartorius 30 Mar 2021

Specific protein may prevent cancer cell death, increase cancer metastasis

One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood cancer could spread, a study from the University of Notre Dame has shown.

30 Mar 2021

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2 - the virus that causes COVID-19 – and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects. In their experiments in fruit flies and human cell lines, the team discovered the cell process that the virus hijacks, illuminating new potential candidate drugs that could be tested for treating severe COVID-19 disease patients.

29 Mar 2021

Advanced technology provides a fine-grained picture of lung pathology in COVID-19

A team led by investigators at Weill Cornell Medicine and NewYork-Presbyterian has used advanced technology and analytics to map, at single-cell resolution, the cellular landscape of diseased lung tissue in severe COVID-19 and other infectious lung diseases.

29 Mar 2021

Therapeutics News and Research

Study suggests T-cells don't determine survival in severe COVID-19

Researchers to test a promising treatment for high-risk COVID-19 outpatients

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Research finds possible explanation for why many cancer drugs don't work in human trials

Stem cell transplants offer long-term benefits for pediatric cancer patients receiving immunotherapy

Single injection of RNA therapy improves vision in patient with genetic form of childhood blindness

Study sheds new light on the role of oxygen deprivation in cancer development

Objectives, challenges and opportunities of new IASLC Molecular Database Project

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

Combination of two existing drugs can kill cancer cells

Research consortium identifies cell stress mechanisms for chronic inflammatory liver disease

Researchers develop novel test that screens for SARS-CoV-2 variants of concern

SwiftScale Biologics: Cell-Free Synthesis of Biologics

Specific protein may prevent cancer cell death, increase cancer metastasis

FDA-approved cancer drug blunts SARS-CoV-2 protein's detrimental effects

Advanced technology provides a fine-grained picture of lung pathology in COVID-19

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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