immunity News and Research

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Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

A team of scientists from Australia has recently identified a frameshift deletion mutation in ORF7a of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mutation results in the production of a truncated peptide with altered functionality. The study is currently available on the medRxiv* preprint server while awaiting peer review.

24 Aug 2021

Patients on dialysis show reduced antibody levels four months after COVID-19 vaccination

A new longitudinal study posted to the medRxiv* preprint server suggests vaccinated patients on chronic hemodialysis having waning immunity against severe acute respiratory syndrome 2 (SARS-CoV-2) variants of concern. The German researchers found a drop in neutralizing antibody levels and T cell activity four months after receiving their second Pfizer-BioNTech vaccine.

24 Aug 2021

FDA approves COVID-19 mRNA vaccine that uses fundamental Penn technology

The U.S. Food and Drug Administration has given the first full approval to a COVID-19 mRNA vaccine, which uses modified mRNA technology invented and developed by scientists in the Perelman School of Medicine at the University of Pennsylvania, whose years of research in mRNA science laid a critical piece of the foundation for the largest global vaccination campaign in history.

23 Aug 2021

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

A new study determined the antibody response to SARS-CoV-2 and seasonal viruses induced by BNT162b2-Comirnaty vaccination in healthcare workers.

23 Aug 2021

New study reveals unique immune responses to SARS-CoV-2, Ebola and respiratory syncytial virus using B cell repertoire analysis

A new study has been published on the bioRxiv* preprint server, which takes a long-read repertoire amplification approach to better understand, compare and contrast B cell responses to emerging or endemic viruses.

23 Aug 2021

UK Health Security Agency launches antibody surveillance program for the general public

Thousands of adults a day will be given free access to antibody tests through a new national surveillance programme launched by the UK Health Security Agency next week, to help improve our understanding of immunity against COVID-19 from vaccination and infection.

23 Aug 2021

Experts fear rapid spread of COVID-19 in Afghanistan given Taliban's hostility to vaccinations

Given the Taliban's hostility to vaccinations, WHO and medical experts fear a rapid and uncontrolled spread of COVID-19 in Afghanistan will await the formation of a new government led by the 'Islamic Scholars'.

20 Aug 2021

New antibody found to be highly protective against wide range of COVID-19 virus variants

The virus that causes COVID-19 today is not the same as the one that first sickened people way back in December 2019.

20 Aug 2021

A combination of oral bacteria and intranasal vaccine provide protection from influenza A virus and COVID-19

A new study published in the journal mBio focuses on the role of nasal bacteria in eliciting virus-specific adaptive immunity.

20 Aug 2021

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

A new study describes how monoclonal antibodies raised against SARS-CoV-2 are affected by mutations in the antibody binding site.

20 Aug 2021

SARS-CoV-2 lambda variant escapes immune response via spike mutations

A new study explores the mechanism by which the SARS-CoV-2 lambda variant has acquired immune evasion capabilities above that of the wildtype.

20 Aug 2021

‘We sent a terrible message’: Scientists say Biden jumped the gun with vaccine booster plan

The Biden administration's plans to make covid-19 booster shots available next month has drawn a collective scream of protest from the scientific community.

20 Aug 2021

Vaccines remain the most effective way to protect against COVID-19 Delta variant, study says

Obtaining two vaccine doses remains the most effective way to ensure protection against the COVID-19 Delta variant of concern dominant in the UK today, according to a study from the University of Oxford.

19 Aug 2021

Research uses mathematical modeling to find an equitable way for sharing vaccines between nations

New research from the University of Oxford and the UK Centre for Ecology & Hydrology, published today in Frontiers in Public Health, uses mathematical modeling to determine the most equitable way to share vaccines between nations.

19 Aug 2021

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Study shows an increase in home drinking during COVID-19 pandemic

During the COVID-19 pandemic months of March 2020 to September 2020, U.S. alcohol retail store sales increased compared to usual trends while food services and drinking places sales decreased markedly during the same period, according to a new study at Columbia University Mailman School of Public Health.

19 Aug 2021

Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

In a small study published in the medRxiv* preprint server, people given a booster Johnson & Johnson COVID-19 shot showed elevated and robust antibody levels.

19 Aug 2021

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

A striking new study examines how far antibodies elicited by vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or by natural infection, can neutralize the closely related bat coronavirus (CoV) RaTG13.

19 Aug 2021

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

A fascinating and timely new study shows how the Delta variant of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) achieved higher transmissibility and resistance to neutralization.

19 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

immunity News and Research

Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

Patients on dialysis show reduced antibody levels four months after COVID-19 vaccination

FDA approves COVID-19 mRNA vaccine that uses fundamental Penn technology

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

New study reveals unique immune responses to SARS-CoV-2, Ebola and respiratory syncytial virus using B cell repertoire analysis

UK Health Security Agency launches antibody surveillance program for the general public

Experts fear rapid spread of COVID-19 in Afghanistan given Taliban's hostility to vaccinations

New antibody found to be highly protective against wide range of COVID-19 virus variants

A combination of oral bacteria and intranasal vaccine provide protection from influenza A virus and COVID-19

SARS-CoV-2 mutations alter dynamics of neutralizing antibodies

SARS-CoV-2 lambda variant escapes immune response via spike mutations

‘We sent a terrible message’: Scientists say Biden jumped the gun with vaccine booster plan

Vaccines remain the most effective way to protect against COVID-19 Delta variant, study says

Research uses mathematical modeling to find an equitable way for sharing vaccines between nations

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

Study shows an increase in home drinking during COVID-19 pandemic

Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

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