immunity News and Research

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Analysis finds untapped potential for immunotherapy in older cancer patients

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

13 Sep 2021

An oral COVID-19 vaccine induces mucosal and protective immunity

Researchers have collaborated to resolve the aforementioned problems associated with injection vaccines to create a thermostable vaccine that can be taken orally.

13 Sep 2021

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

Scientists were inspired by the robust serum nAb responses in people who recovered from natural SARS-CoV-2 infection and were later vaccinated using mRNA vaccine. They isolated and characterized bnAbs from two COVID-19 convalescent donors who were recently vaccinated. These isolated bnAbs were found to be highly potent against sarbecoviruses. This research is available on the bioRxiv* preprint server.

13 Sep 2021

Functional impairment of HIV-specific T cells precedes aborted virus control

HIV is a master of evading the immune system, using a variety of methods to prevent the body from being able to find and kill it.

13 Sep 2021

Researchers find a way to turn SARS-CoV-2’s virulence mechanism against itself

A recent study, currently available on the bioRxiv* preprint server, reveals that a specific region of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be targeted by antisense oligonucleotides to potently inhibit viral replication, and consequently the development of coronavirus disease (COVID-19).

12 Sep 2021

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

A recent report published in the journal Cell Discovery has described the immunogenicity and protective efficacy of a novel coronavirus disease 2019 (COVID-19) subunit vaccine candidate. The vaccine induces robust immune responses in rodents and non-human primates and protects the animals against severe disease.

12 Sep 2021

Researchers identify the spleen as primary site for priming of 'killer' T cells during influenza infection

CD8+ T cells - known as "killer" T cells - are the assassins of the immune system. Once they are primed, they seek out and destroy other cells that are infected with virus or cells that are cancerous.

12 Sep 2021

Introduction of COVID-19 vaccine passports in the UK may lower vaccination inclination

Introducing COVID-19 vaccine passports in the UK could see people who are willing to get vaccinated do so more quickly, but have the converse effect upon those who have concerns, especially when passports cover domestic activities, suggests a new study published in EClinicalMedicine.

11 Sep 2021

UM researcher wins $2.5 million NSF grant to study hantavirus disease transmission

University of Montana researcher Angela Luis has been awarded a National Science Foundation grant to study how diversity of competitor species affects infectious disease transmission in wildlife – specifically hantavirus in deer mice.

10 Sep 2021

Brown researchers receive $4.9 million to study COVID-19 vaccine effectiveness in older adults

To address the pressing issue of diminishing immunity among older adults to COVID-19 as well to vaccines designed to protect against the virus, a $4.9 million award from the U.S. Centers for Disease Control and Prevention will fund a two-year project led by Brown University researchers and conducted by a team spanning multiple institutions.

10 Sep 2021

Study identifies FDA-approved drugs that are effective in suppressing SARS-CoV-2 replication

Despite the development of SARS-CoV-2 vaccines, effective therapeutics are needed until worldwide immunity has been achieved.

10 Sep 2021

No evidence of pre-existing antibody and B cell immunity against SARS-CoV-2 in unexposed adults

A group of researchers analyzed the B cell response to SARS-CoV-2 in unexposed individuals.

10 Sep 2021

Virus-like nanoparticle vaccine effective against SARS-CoV-2 in animal model

A COVID-19 vaccine, created from a virus-like nanoparticle that displays SARS-CoV-2 spike protein RBDs, effectively protects animal model from infection.

10 Sep 2021

'Cold' tumors can be turned 'hot' with extremely low doses of radiation, study shows

A Ludwig Cancer Research study conducted in both mice and a small group of patients with advanced cancers has shown that so-called “cold” tumors that are nearly devoid of immune cells—and therefore unresponsive to immunotherapy—can be turned “hot” with extremely low doses of radiation and the rational use of existing therapies.

9 Sep 2021

Allergic reactions provide protection against yeast-triggered asthma, research shows

We think of asthma and other allergic diseases as unnecessary aberrant immune responses that do more harm than good. However, new evidence by an international team led by researchers at Baylor College of Medicine shows that some allergic reactions provide necessary protection against highly invasive and potentially lethal infectious agents, such as yeast.

9 Sep 2021

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome - the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts - can impact us in a variety of different ways, from our metabolism to our mood.

9 Sep 2021

Understanding the changing coronavirus landscape

With the emergence of new SARS-CoV-2 variants such as beta and delta, people are not only getting a refresher course on the Greek alphabet but also experiencing confusion and anxiety about what the variants mean for public health.

9 Sep 2021

Mu SARS-CoV-2 variant highly resistant to neutralization by convalescent and vaccinated sera

Researchers in Japan have warned that the Mu (B.1.621) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – appears to be highly resistant to neutralization by sera from convalescent or vaccinated individuals.

8 Sep 2021

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

Researchers in Australia have developed a coronavirus disease 2019 (COVID-9) vaccine that induced robust and long-lived humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in both young and aging mice.

8 Sep 2021

The role of nanobodies in capturing and containing SARS-CoV-2

Scientists have repurposed the Nb Ty1 for the detection and neutralization of SARS-CoV-2.

8 Sep 2021

immunity News and Research

Analysis finds untapped potential for immunotherapy in older cancer patients

An oral COVID-19 vaccine induces mucosal and protective immunity

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

Functional impairment of HIV-specific T cells precedes aborted virus control

Researchers find a way to turn SARS-CoV-2’s virulence mechanism against itself

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

Researchers identify the spleen as primary site for priming of 'killer' T cells during influenza infection

Introduction of COVID-19 vaccine passports in the UK may lower vaccination inclination

UM researcher wins $2.5 million NSF grant to study hantavirus disease transmission

Brown researchers receive $4.9 million to study COVID-19 vaccine effectiveness in older adults

Study identifies FDA-approved drugs that are effective in suppressing SARS-CoV-2 replication

No evidence of pre-existing antibody and B cell immunity against SARS-CoV-2 in unexposed adults

Virus-like nanoparticle vaccine effective against SARS-CoV-2 in animal model

'Cold' tumors can be turned 'hot' with extremely low doses of radiation, study shows

Allergic reactions provide protection against yeast-triggered asthma, research shows

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

Understanding the changing coronavirus landscape

Mu SARS-CoV-2 variant highly resistant to neutralization by convalescent and vaccinated sera

New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

The role of nanobodies in capturing and containing SARS-CoV-2

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