Prophylaxis News and Research

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Trial results show CAB LA is more effective in preventing HIV acquisition in women

The HIV Prevention Trials Network study (HPTN 084) on the safety and efficacy of the long-acting injectable antiretroviral drug cabotegravir (CAB LA), for pre-exposure prophylaxis (PrEP) in HIV-uninfected women, was stopped early by the trial Data and Safety Monitoring Board (DSMB) as results showed CAB LA to be highly effective in preventing HIV acquisition.

10 Nov 2020

Lupus patients receiving prophylactic therapy are at high risk for adverse reactions

New research shows that adults with systemic lupus erythematosus, who receive trimethoprim-sulfamethoxazole (TMP-SMX), a prophylactic therapy to help prevent pneumocystis pneumonia, are at high risk for adverse reactions to the drug, particularly if they are also positive for anti-Smith (anti-Sm) antibodies.

6 Nov 2020

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

A new mathematical modeling study by Ashish Goyal and colleagues, informed by data collected from 25 patients hospitalized with COVID-19 in 4 different countries, offers some important new insights into the optimal timing of 4 different antiviral therapies to combat the disease.

23 Oct 2020

Hydroxychloroquine does not prevent COVID-19 in health care workers, trial shows

University of Minnesota Medical School physician researchers studied hydroxychloroquine as a treatment to prevent COVID-19 for those with high-risk for exposure to the virus - health care workers.

21 Oct 2020

Older males who have recovered from COVID-19 are best plasma donors for treatment

Sex, age, and severity of disease may be useful in identifying COVID-19 survivors who are likely to have high levels of antibodies that can protect against the disease, according to a new study co-led by researchers at Johns Hopkins Bloomberg School of Public Health.

20 Oct 2020

Zinc deficiency linked to poor COVID-19 outcomes

A team of researchers from various universities and institutes in Spain recently published a paper on the preprint server medRxiv,* in which they hypothesize that serum zinc levels have a significant influence on COVID-19 progression and thus may be a useful biomarker in predicting severe disease in early stages of COVID-19 infection.

12 Oct 2020

Temporal predictors of SARS-CoV-2 antibodies

Researchers in a recent paper published as a preprint on the preprint medRxiv, study the clinical factors, the laboratory assays to streamline plasma donor selection, and the durability of nAb responses in adults.

11 Oct 2020

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Researchers in the United States and Canada have discovered a monoclonal antibody that potently neutralizes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

5 Oct 2020

The implications of COVID-related sexual distancing and clinical service interruption

A recent study conducted in the Atlanta area reveals that coronavirus disease 2019 (COVID-19) related sexual distancing together with clinical service interruption for sexually transmitted diseases can potentially impact the future incidence of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The study is currently available on the medRxiv* preprint server.

4 Oct 2020

Ultrapotent antibody mix locks infection machinery, inhibits SARS-CoV-2 attachment to cells

A mix of ultrapotent antibodies from recovered COVID-19 patients has been shown to recognize and lock down the infection machinery of the pandemic coronavirus and keep it from entering cells. Each of the antibody types performs these overlapping tasks slightly differently.

25 Sep 2020

Study explores women's interest in long-acting injectable PrEP to prevent HIV

Oral pre-exposure prophylaxis (PrEP) is a highly effective method of reducing risk for HIV, yet use of PrEP is uniformly low, especially among women.

22 Sep 2020

Providing personalized care for bleeding disorders

An interview with Dr. Carmen Escuriola-Ettingshausen MD, Mörfelden-Walldorf, Germany on providing personalized care for bleeding disorders.

From Takeda 21 Sep 2020

Providing personalized care for bleeding disorders

An interview with Dr. Carmen Escuriola-Ettingshausen MD, Mörfelden-Walldorf, Germany on providing personalized care for bleeding disorders.

From Takeda 21 Sep 2020

PrEP prescribing is not routine for many medical practitioners, study finds

Only about 54% of medical practitioners surveyed say they have prescribed pre-exposure prophylaxis, or PrEP, to HIV-vulnerable patients, according to a new study by a Vanderbilt University Medical Center investigator.

17 Sep 2020

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

In a study published on the bioRxiv preprint server, researchers from the University of Pécs, University of Vienna, and CEBINA GmbH, Vienna, show the ability of the antihistamine azelastine to inhibit SARS-CoV-2 infection in human nasal tissue in vitro.

16 Sep 2020

State-level policies are crucial to HIV prevention efforts

HIV prevention remains a public health priority in the United States. Pre-exposure prophylaxis (PrEP) is a drug regimen recommended for individuals who have engaged in behaviors that place them at elevated risk for HIV.

9 Sep 2020

Countries should step-up leprosy prevention initiatives to accelerate decline in new cases

New cases of leprosy are decreasing, but not at the anticipated rate. In order to accelerate the annual decline, countries should screen contacts and treat eligible contacts with single-dose rifampicin, as recommended by the World Health Organization in its guidelines.

8 Sep 2020

Prophylaxis News and Research

Trial results show CAB LA is more effective in preventing HIV acquisition in women

Lupus patients receiving prophylactic therapy are at high risk for adverse reactions

Mathematical modeling study offers new insights into optimal timing of antiviral therapies against COVID-19

Hydroxychloroquine does not prevent COVID-19 in health care workers, trial shows

Older males who have recovered from COVID-19 are best plasma donors for treatment

Zinc deficiency linked to poor COVID-19 outcomes

Temporal predictors of SARS-CoV-2 antibodies

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

The implications of COVID-related sexual distancing and clinical service interruption

Ultrapotent antibody mix locks infection machinery, inhibits SARS-CoV-2 attachment to cells

Study explores women's interest in long-acting injectable PrEP to prevent HIV

Providing personalized care for bleeding disorders

Providing personalized care for bleeding disorders

PrEP prescribing is not routine for many medical practitioners, study finds

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

State-level policies are crucial to HIV prevention efforts

Countries should step-up leprosy prevention initiatives to accelerate decline in new cases

D-dimer - A sensitive novel biomarker of COVID-19 mortality

Researchers launch study to evaluate safety of HIV prevention methods in breastfeeding women

WHO urges the public to avoid routine dental work amid the coronavirus pandemic

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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