Tumor Necrosis Factor News and Research

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High-throughput proteomics reveals pregnancy-specific responses to COVID-19

Researchers evaluated pregnancy-specific responses to SARS-CoV-2 infection.

29 Aug 2022

Researchers report large molecular compounds and nanoscale nanozyme of two traditional Chinese medicines may inhibit COVID-19 signaling

Researchers investigated the potential anti-COVID-19 activity of traditional Chinese medicine.

25 Aug 2022

Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19

A new study examines the potential benefit of the glucokinase activator molecule AZD1656 in the ARCADIA trial.

23 Aug 2022

Review of natural products with promising anti-SARS-CoV-2 potential

In a new study, researchers reviewed existing literature on naturally active products with therapeutic efficacy against SARS-CoV-2.

10 Aug 2022

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Researchers assess the impact of extending the interval between primary and booster COVID-19 vaccine doses.

9 Aug 2022

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Scientists review current literature associated with the role of the gut-brain axis in AD pathogenesis.

9 Aug 2022

The safety and preliminary efficacy of OP-101 in patients with severe COVID-19

Researchers assessed the impact of dendrimer nanotherapy in treating severe COVID-19.

8 Aug 2022

Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

Disease progression in the rhesus macaque model upon inoculation with the Delta, Omicron BA.1, and Omicron BA.2 variants

Researchers compared the severity levels of disease caused by different SARS-CoV-2 variants of concern in the rhesus macaque model.

4 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Less efficient replication of ancestral SARS-CoV-2 in primary nasal epithelium of children

A new study revealed that the replication of the ancestral strain of SARS-CoV-2 is less efficient in nasal epithelial cells (NECs) of children.

3 Aug 2022

What is the immunopathogenesis of pediatric COVID-19?

Researchers assessed the immunopathogenesis of COVID-19 infection in children.

1 Aug 2022

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Researchers review current developments in preclinical studies associated with recombinant ACE2 decoy receptors against coronaviruses.

31 Jul 2022

Tannins as therapeutic agents against SARS-CoV-2

Researchers reviewed tannins as therapeutic agents against SARS-CoV-2.

29 Jul 2022

Novel compound inhibits SARS-CoV-2 replication by binding a genome target

Researchers assessed the biodistribution and safety of SBCoV202, a novel antiviral agent based on antisense technology that can specifically and effectively bind to the SARS-CoV-2 genome target to inhibit SARS-CoV-2 replication.

27 Jul 2022

How COVID-19 affects the brain microvasculature

A recent study discusses the effects of COVID-19 on the brain microvascular system.

25 Jul 2022

Scientists explore SARS-CoV-2 spike protein and platelet-activating factor

Researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein.

25 Jul 2022

Phase 2a clinical trial describes safety and efficacy of dendrimer nanotherapy in severe COVID-19 patients

A multicenter, randomized, placebo-controlled phase 2a clinical trial has recently been conducted to evaluate the efficacy of a nanotherapeutic compound OP-101 in treating severe COVID-19 patients.

21 Jul 2022

UK study finds an increase in cardiovascular diseases and diabetes up to 12 months after COVID-19

Researchers determined whether the incidence of new diabetes mellitus (DM) and cardiovascular diseases (CVDs) increases in a year among those recovering from COVID-19.