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Stressed-out mice reveal role of epigenetics in behavior

Research conducted by a team in Switzerland suggests that a family of genes involved in regulating the expression of other genes in the brain is responsible for helping us deal with external inputs such as stress.

12 Dec 2008

New cause of atrial fibrillation found

A new study shows that atrial fibrillation--the most common form of sustained heart arrhythmia--can be caused in an unexpected way.

12 Dec 2008

Aromatase inhibitors most effective in preventing breast cancer from coming back

Two separate meta-analyses of clinical trials from around the world that tested tamoxifen against aromatase inhibitor drugs in postmenopausal women with early breast cancer have each reached the same conclusion: aromatase inhibitors are more effective in preventing breast cancer from coming back.

12 Dec 2008

New understanding on how the brain controls onset of puberty

A team of scientists from the University of Cambridge and the University of Cukurova in Turkey have taken a major step to understanding how the brain controls the onset of puberty.

12 Dec 2008

Estrogen therapy can help control metastatic breast cancer

For breast cancer survivors, the idea of taking estrogen pills is almost a taboo. In fact, their doctors give them drugs to get rid of the hormone because it can fuel the growth of breast cancer.

12 Dec 2008

Delcath Systems enrols first fifty percent in trial treating metastatic cutaneous and ocular melanoma to the liver

Delcath Systems, Inc. has announced that the first fifty percent (46 of 92) of patients have been enrolled in the Phase III clinical trial treating metastatic cutaneous and ocular melanoma to the liver.

12 Dec 2008

Trial looks at new treatment for solid cancer tumors and non-Hodgkin's lymphoma

Researchers at The Cancer Institute of New Jersey (CINJ) have opened a clinical trial, which aims to evaluate a new treatment for solid cancer tumors and non-Hodgkin's lymphoma (NHL) in combination with a chemotherapy agent called cyclophosphamide.

12 Dec 2008

Scientists show that HIV's evolution in the body does not occur at a constant rate

HIV is so deadly largely because it evolves so rapidly. With a single virus as the origin of an infection, most patients will quickly come to harbor thousands of different versions of HIV, all a little bit different and all competing with one another to most efficiently infect that person's cells. Its rapid and unique evolution in every patient is what allows HIV to evade the body's defenses and gives the virus great skill at developing resistance to a pantheon of antiviral drugs.

12 Dec 2008

AstraZeneca responds to FDA advisory committees' recommendation on SYMBICORT

On December 11, 2008, the Joint Advisory Committees of the U.S. Food and Drug Administration (FDA) - including the Drug Safety & Risk Management Advisory Committee, the Pediatric Advisory Committee, and the Pulmonary-Allergy Drugs Advisory Committee - completed a review of the benefits and risks of asthma medications containing long-acting beta-agonists (LABAs).

12 Dec 2008

AEterna Zentari completes recruitment for phase 3 trial with Cetrorelix in benign prostatic hyperplasia

AEterna Zentaris Inc. has reported it has reached its goal of recruiting 500 patients for the safety study of the Phase 3 program in benign prostatic hyperplasia (BPH) with its flagship product candidate, cetrorelix, a novel investigational luteinizing hormone-releasing hormone (LHRH) antagonist.

11 Dec 2008

Decline in teen marijuana use stalls - trends in cigarette and alcohol use continues to fall

There are signs that the ongoing decline in teen marijuana use in recent years has stalled; however the downward trend in cigarette and alcohol use continues, according to the 2008 Monitoring the Future (MTF) Survey. Results were announced today at a news conference.

11 Dec 2008

Transplanted fat cells restore function after spinal cord injury

A study published in the current issue of Cell Transplantation (Vol.17, No. 8) suggests that mature adipocytes - fat cells - could become a source for cell replacement therapy to treat central nervous system disorders.

10 Dec 2008

Sugar is addictive

A Princeton University scientist will present new evidence today demonstrating that sugar can be an addictive substance, wielding its power over the brains of lab animals in a manner similar to many drugs of abuse.

10 Dec 2008

RNA interference can facilitate vaccine development

Pharmaceutical companies and universities are racing to develop drugs that use the gene silencing mechanism known as RNA interference to treat a host of diseases.

10 Dec 2008

Pralatrexate shows promise for T-Cell lymphoma

Preliminary results of a pivotal Phase 2 clinical trial of pralatrexate (PDX), a drug that partially works by mimicking folic acid, showed a complete or partial response in 27 percent of patients with recurrent or resistant peripheral T-cell lymphoma (PTCL).

10 Dec 2008

Researchers find inherited genetic variation in nicotine addiction

A new study from the Abramson Cancer Center and Department of Psychiatry in the University of Pennsylvania School of Medicine shows that smokers who carry a particular version of a gene for an enzyme that regulates dopamine in the brain may suffer from concentration problems and other cognitive deficits when abstaining from nicotine - a problem that puts them at risk for relapse during attempts to quit smoking.

10 Dec 2008

Nonhormonal treatment regimens improve survival in patients with metastatic breast cancer

Nonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced (metastatic or recurrent inoperable) breast cancer over the last 35 years, according to a systematic review published December 9 in the Journal of the National Cancer Institute.

10 Dec 2008

New technique may provide quicker and easier way of developing protein-based drugs

Research by a Michigan State University chemist could eventually lead to a quicker and easier way of developing protein-based drugs that are key to treating a number of diseases, including cancer, diabetes and hepatitis.

10 Dec 2008

Hormone therapy for prostate cancer does not appear to increase cardiac deaths

Treating prostate cancer patients with drugs that block hormonal activity does not appear to increase the risk of death from cardiovascular disease, according to a study led by Massachusetts General Hospital (MGH) researchers.

10 Dec 2008

High phosphorus levels in blood linked to coronary calcification in chronic kidney disease

For patients with moderate chronic kidney disease (CKD), higher levels of phosphorus in the blood are associated with increased calcification of the major arteries and heart valves - which may contribute to the increased risk of cardiovascular disease in patients with CKD, reports a study in the Journal of the American Society of Nephrology (JASN).

10 Dec 2008

Drugs News and Research

Stressed-out mice reveal role of epigenetics in behavior

New cause of atrial fibrillation found

Aromatase inhibitors most effective in preventing breast cancer from coming back

New understanding on how the brain controls onset of puberty

Estrogen therapy can help control metastatic breast cancer

Delcath Systems enrols first fifty percent in trial treating metastatic cutaneous and ocular melanoma to the liver

Trial looks at new treatment for solid cancer tumors and non-Hodgkin's lymphoma

Scientists show that HIV's evolution in the body does not occur at a constant rate

AstraZeneca responds to FDA advisory committees' recommendation on SYMBICORT

AEterna Zentari completes recruitment for phase 3 trial with Cetrorelix in benign prostatic hyperplasia

Decline in teen marijuana use stalls - trends in cigarette and alcohol use continues to fall

Transplanted fat cells restore function after spinal cord injury

Sugar is addictive

RNA interference can facilitate vaccine development

Pralatrexate shows promise for T-Cell lymphoma

Researchers find inherited genetic variation in nicotine addiction

Nonhormonal treatment regimens improve survival in patients with metastatic breast cancer

New technique may provide quicker and easier way of developing protein-based drugs

Hormone therapy for prostate cancer does not appear to increase cardiac deaths

High phosphorus levels in blood linked to coronary calcification in chronic kidney disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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