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New genomics workbook helps people use their family history to assess disease risks

Researchers at the National Human Genome Research Institute, part of the National Institutes of Health, have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps people use their family history to assess their risk for heart disease, diabetes, breast cancer and colorectal cancer.

8 Jul 2021

Study uncovers mutations in Polycomb group gene as underlying cause of novel neurological disorder

A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder.

8 Jul 2021

Genetic analysis method reveals causal association between thyroid function and serum lipid metabolism

Thyroid hormones are amino acid-based molecules produced by the thyroid gland. Involved in direct or indirect regulation of key metabolic pathways, these molecules play critical roles in the development and normal functioning of the body.

8 Jul 2021

Do lockdowns exert selection pressure on overdispersion of SARS-CoV-2 variants?

New research recently released on the medRxiv* preprint server describes a mathematical model that has been developed to evaluate competitions between variants that differ in their level of overdispersion (k) and their mean infectiousness.

8 Jul 2021

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

A new article has been published in Cellular and Molecular Lifesciences, which focuses on the connection between host factors and the worsening of the COVID-19. Further, the impact of the virus on the host’s microbiome and secondary infection has also been studied.

8 Jul 2021

Researchers determine the structure of nanomachine essential for functioning of mTOR

The principle that form follows function does not only apply to design and architecture. It also applies to biology

8 Jul 2021

Optical genome mapping could change the existing workflow within cytogenetic laboratories

Dutch-French research shows that Optical Genome Mapping (OGM) detects abnormalities in chromosomes and DNA very quickly, effectively and accurately. Sometimes even better than all existing techniques together, as they describe in two proof-of-concept studies published in the American Journal of Human Genetics.

8 Jul 2021

How SARS-CoV-2 has evolved over the course of the pandemic

In an effort to understand the ongoing evolution of the SARS-CoV-2 genome, researchers constructed a phylogenetic tree of all available SARS-CoV-2 genomes.

7 Jul 2021

B.1.427/B.1.429 variant of SARS-CoV-2 evades neutralization via disulfide bond rearrangement

A new paper discusses an intriguing new mechanism of immune evasion traceable to specific mutations in the B.1.427/B.1.429 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

7 Jul 2021

Mother-to-baby SARS-CoV-2 transmission in pregnancy possible but rare, says study

A new meta-analysis, released on the medRxiv* preprint server, suggests that, though possible, the virus is rarely transmitted to the newborn in real life. A scientific brief from the World Health Organization (WHO) in February 2021 describes three mechanisms by which the virus might be transmitted from the mother to the fetus or newborn.

7 Jul 2021

New study reports low SARS-CoV-2 breakthrough infections in vaccinated healthcare workers

Researchers examined cases of SARS-CoV-2 infection in fully and partially vaccinated healthcare workers, finding that vaccination provided strong immunity to the virus even though VOCs are on the rise in the non-vaccinated community at large.

7 Jul 2021

Rare genetic variants have a big impact on the risk of developing type 2 diabetes

Scientists at the University of Cambridge have identified rare genetic variants - carried by one in 3,000 people - that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect.

7 Jul 2021

Vaccinate big cats? New report shows SARS-CoV-2 Delta variant infecting endangered lions

There is evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infecting animals such as ferrets, fruit bats, and cats. New research led by Vijendra Pal Singh from the ICAR-National Institute of High Security Animal Disease in India suggests it might be time to vaccinate the big cats as well. Their report details SARS-CoV-2 infection in nine Asiatic lions caused by the SARS-CoV-2 Delta variant (B.1.617.2).

7 Jul 2021

SARS-CoV-2 Lambda variant spreading rapidly in South America, report reveals

A new research paper by researchers in Peru describes a new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known as the Lambda variant (C.37). The Lambda variant was first reported in Lima, Peru, in December 2020, and from April 2021, nearly all the coronavirus infections in the country are caused by it.

7 Jul 2021

Synthetic defective SARS-CoV-2 could be used as a self-promoting antiviral therapy

What if the COVID-19 virus could be used against itself? Researchers at Penn State have designed a proof-of-concept therapeutic that may be able to do just that. The team designed a synthetic defective SARS-CoV-2 virus that is innocuous but interferes with the real virus's growth, potentially causing the extinction of both the disease-causing virus and the synthetic virus.

7 Jul 2021

COVID-19 vaccination may be stemming evolution of “fitter” SARS-CoV-2 variants

Researchers in the United States and India have presented the first known evidence that the rollout of coronavirus disease 2019 (COVID-19) vaccination is restricting the evolutionary and immune escape pathways accessible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2021

Genome News and Research

New genomics workbook helps people use their family history to assess disease risks

Study uncovers mutations in Polycomb group gene as underlying cause of novel neurological disorder

Genetic analysis method reveals causal association between thyroid function and serum lipid metabolism

Do lockdowns exert selection pressure on overdispersion of SARS-CoV-2 variants?

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

Researchers determine the structure of nanomachine essential for functioning of mTOR

Optical genome mapping could change the existing workflow within cytogenetic laboratories

How SARS-CoV-2 has evolved over the course of the pandemic

B.1.427/B.1.429 variant of SARS-CoV-2 evades neutralization via disulfide bond rearrangement

Mother-to-baby SARS-CoV-2 transmission in pregnancy possible but rare, says study

New study reports low SARS-CoV-2 breakthrough infections in vaccinated healthcare workers

Rare genetic variants have a big impact on the risk of developing type 2 diabetes

Vaccinate big cats? New report shows SARS-CoV-2 Delta variant infecting endangered lions

SARS-CoV-2 Lambda variant spreading rapidly in South America, report reveals

Synthetic defective SARS-CoV-2 could be used as a self-promoting antiviral therapy

COVID-19 vaccination may be stemming evolution of “fitter” SARS-CoV-2 variants

NYUAD researchers unlock an epigenetic code that allows liver regeneration

Comprehensive genetic study provides new insights on cleft lip and palate

Eight new research projects to explore COVID-19 variants of concern in Canada

Developing a face mask that can detect COVID-19

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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