Central Nervous System News and Research

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Weight control protein may yield new approaches for treating obesity and type 2 diabetes

The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

16 Aug 2005

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

Oxford scientists have contributed to the genome sequencing of two parasites which cause major health problems in the developing world.

15 Aug 2005

No link between multiple vaccinations and infections

Over the years many concerns have been raised about chilhood vacinations, and one concern has been that multiple vaccinations 'use up' the immune system, so children are unable to fight off other illnesses.

10 Aug 2005

High insulin levels increase inflammatory markers and beta-amyloids

Moderately elevated levels of insulin increase the levels of inflammatory markers and beta-amyloid in plasma and in cerebrospinal fluid, and these markers may contribute to Alzheimer's disease, according to a new study posted online today from Archives of Neurology, one of the JAMA/Archives journals.

9 Aug 2005

Findings do not support the hypothesis of increased risk of nontargeted infectious disease hospitalization after childhood vaccination

New research does not support a belief that children receiving multiple vaccines increase their risk of hospitalization for a nontargeted infectious disease, according to a study in the August 10 issue of JAMA: The Journal of the American Medical Association.

9 Aug 2005

MediciNova starts phase II clinical trial of MN-166 for multiple sclerosis

MediciNova today announced the enrollment of patients in a Phase II clinical study with MN-166 for the treatment of multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. MN-166 is an orally administered drug with a novel mechanism of action that includes the inhibition of phosphodiesterase IV.

2 Aug 2005

Researchers reveal secret of key protein in brain and heart function

Brown University biologists have solved the structure of a critical piece of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, where it is believed to play a role in everything from cardiac contractions to memory creation. Results are published in The Journal of Biological Chemistry.

31 Jul 2005

First trial of pramipexole for the treatment of fibromyalgia

The mechanism of fibromyalgia, a chronic illness characterized by muscle pain, fatigue, and sleep disturbances, is unknown and medications used to treat it (such as antidepressants, antiepileptics, muscle relaxants, antiinflammatories, sedative hypnotics, pain relievers and nutriceuticals) have had limited success.

28 Jul 2005

TEVA to acquire IVAX for $7.4 billion

TEVA Pharmaceutical Industries and IVAX Corporation have jointly announced that they have signed a definitive agreement providing for the acquisition of IVAX by TEVA.

26 Jul 2005

Spectrum Pharmaceuticals receives notice of a U.S. patent allowance for potential drug fo ADHD

Spectrum Pharmaceuticals has announced that it has received from the U.S. Patent and Trademark Office (USPTO) a Notice of Allowance for its patent application for SPI-339 entitled "Methods for Treating Cognitive/Attention Deficit Disorders Using Tetrahydroindolone Analogues and Derivatives."

21 Jul 2005

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take."

19 Jul 2005

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Physiologists and medical researchers have long recognized the important endocrine roles played by the pituitary hormones oxytocin (OT) and vasopressin (VP) on peripheral systems in lactation, uterine contraction and urine concentration.

19 Jul 2005

Transplanted neural stem cells may serve not only as replacement cells for tissue repair, but in some circumstances may also protect the brain from inflammation

Researchers at the San Raffaele Hospital (Milan, Italy) published unexpected results of studies in which immature nerve cells (adult mouse neural stem cells) injected into the blood of mice with MS-like disease were able to suppress the immune attacks that damage the brain and spinal cord tissues.

13 Jul 2005

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

New roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke

In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.

11 Jul 2005

Prescription drug abuse in the USA exceeds 15 million

A recently released report by the National Center on Addiction and Substance Abuse at Columbia University suggests between 1992 and 2003, more Americans were abusing controlled prescription drugs than cocaine, hallucinogens, inhalants and heroin put together.

11 Jul 2005

Showering in manganese-contaminated water could have permanent effects on the nervous system

A new analysis based on animal studies suggests that showering in manganese-contaminated water for a decade or more could have permanent effects on the nervous system. The damage may occur even at levels of manganese considered safe by the Environmental Protection Agency, according to researchers from Wake Forest University School of Medicine.

6 Jul 2005

New study shows showering in manganese contaminated water could permanently affect the nervous system

1 Jul 2005

Treatment options for skull base tumors

It is estimated that in 2000, more than 359,000 persons were living with a diagnosis of a primary brain tumor in the United States. In 2005, it is estimated that nearly 12,800 deaths will be associated with malignant tumors of the brain and other parts of the central nervous system. Brain tumors are the leading cause of cancer-related deaths in children age 19 and younger.

28 Jun 2005

Polio still a threat but eradication possible

The director of the U.S. Centers for Disease Control and Prevention (CDC) said this week that despite more than 500 new polio cases being reported worldwide this year, and the disease still posing a threat, the goal of totally eradicating it globally is still within reach.

22 Jun 2005

Central Nervous System News and Research

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

No link between multiple vaccinations and infections

High insulin levels increase inflammatory markers and beta-amyloids

Findings do not support the hypothesis of increased risk of nontargeted infectious disease hospitalization after childhood vaccination

MediciNova starts phase II clinical trial of MN-166 for multiple sclerosis

Researchers reveal secret of key protein in brain and heart function

First trial of pramipexole for the treatment of fibromyalgia

TEVA to acquire IVAX for $7.4 billion

Spectrum Pharmaceuticals receives notice of a U.S. patent allowance for potential drug fo ADHD

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Transplanted neural stem cells may serve not only as replacement cells for tissue repair, but in some circumstances may also protect the brain from inflammation

Research explains one of the fundamental mysteries of multiple sclerosis

New roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke

Prescription drug abuse in the USA exceeds 15 million

Showering in manganese-contaminated water could have permanent effects on the nervous system

New study shows showering in manganese contaminated water could permanently affect the nervous system

Treatment options for skull base tumors

Polio still a threat but eradication possible

Event guide: The 7th CNS Drug Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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