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Large-scale computer simulations reveal new insights into antibiotic resistance

Large-scale computer simulations have pinpointed a tiny change in molecular structure that could account for drug resistance in Streptomices pneumoniae, the organism that causes childhood pneumonia and claims 3.5 million lives a year, mainly in developing countries.

15 Aug 2005

Complications from angioplasty much lower among patients whose doctors perform a large number of those procedures each year

Before patients get their clogged heart arteries re-opened, they may want to ask their doctor just how many such procedures he or she has done, a new study finds. The answer may make a big difference in each patient's risk of suffering a major setback before leaving the hospital.

15 Aug 2005

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

For people with long-standing rheumatoid arthritis, combined treatment with the new "biologic" drug adalimumab and methotrexate is about five times more effective than methotrexate alone, according to a new systematic review of studies.

15 Aug 2005

Abbott receives European approval to market Humira

Abbott has announced that it has received approval from the European Commission to market Humira (adalimumab) as a treatment for psoriatic arthritis and early rheumatoid arthritis (RA) in Europe.

15 Aug 2005

Genomes of Trypanosoma brucei and Trypanosoma cruzi sequenced

Oxford scientists have contributed to the genome sequencing of two parasites which cause major health problems in the developing world.

15 Aug 2005

Key toxin could provide for world's first treatment for Alzheimer's

Dr Karen Cullen at Sydney University’s Institute for Biomedical Research is part of a collaborative team which has identified a key component in the progression of Alzheimer’s disease, a finding which may produce the world’s first effective treatment to combat the debilitating effects of the disease.

15 Aug 2005

FDA places very tight restrictions on acne drug Accutane

The U.S. Food and Drug Administration said late last week, that in future, patients and doctors will have to register with manufacturers and promise to comply with tight restrictions, before using the acne drug Accutane and it's generic versions.

14 Aug 2005

Scientists say valproic acid can eradicate dormant HIV

Early research by scientists in the U.S. suggests that valproic acid could be a potential way to eradicate dormant HIV infections.

14 Aug 2005

Researchers have found a signal that could lead to earlier detection and treatment of ovarian cancer

The Penn State team of scientists led by principal investigator Kathleen M. Mulder, Ph.D., professor of pharmacology, and working in conjunction with a researcher from the Center for Cancer Research, National Cancer Institute in Bethesda, Md., studied "km23," a protein that helps to direct protein traffic in the cell.

13 Aug 2005

Young people in the UK report little difficulty in obtaining cigarettes, alcohol, and other drugs

Reviewing several recent surveys of young people, the authors note that underage smokers can acquire cigarettes easily, often from friends and relatives. Most regular smokers aged 12-15 also say they buy cigarettes from shops.

11 Aug 2005

How some antibiotics kill bacteria

Researchers have uncovered how members of one family of antibiotics kill bacteria that make people sick.

11 Aug 2005

Key step in the production of beta-amyloid

Researchers at UT Southwestern Medical Center have defined a key step in the production of beta-amyloid, a short protein that is thought to be responsible for the development of Alzheimer's disease. Understanding this step may aid in the discovery of drugs that could help block the disease from developing.

11 Aug 2005

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

Introgen announces additional broad patent in China

Introgen Therapeutics has announced that a patent with broad claims directed to combination therapy with the p53 gene and conventional chemotherapy or radiation was issued in China.

11 Aug 2005

Pig brain cell transplant looks hopeful for treating Huntington's disease

According to researchers at Australian bioscience company Living Cell Technologies (LCT), if approved, pig brain cells wrapped in a seaweed derivative could be implanted into human brains by sometime next year to treat Huntington's disease.

11 Aug 2005

Taking parathyroid hormone followed by a year on alendronate shows strong osteoporosis benefit

Postmenopausal women who took a bone-building drug for one year followed by a year on a standard drug that fights bone loss experienced greater increases in bone density than has been reported from any other drug regimen, an NIH-sponsored study has found. Bone density is the standard predictor of fracture risk associated with osteoporosis.

11 Aug 2005