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CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

$Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers$

Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers

Patients with treatment-refractory cancers who received eligibility and testing waivers to participate in a large basket/umbrella oncology trial had similar rates of clinical benefit and adverse events as patients who participated in the trial without waivers.

27 Jun 2024

Math model suggests single-parent nursing evolved to fight off bad bacteria

Being nursed by a single parent could be an evolutionary strategy to curb the spread of harmful microbes in mammals, according to a novel theory developed by mathematicians.

27 Jun 2024

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Schizophrenia is a complicated mental health disorder accompanied by wide range of symptoms such as hallucinations, impaired cognitive ability, and disorganized speech or behavior.

27 Jun 2024

Uptick in early-onset gastrointestinal cancers raises the need for better prevention and diagnosis

Treatment of gastrointestinal (GI) cancers is catching up with other areas of oncology and offering patients better prospects for survival and quality of life, but a significant uptick in early-onset cases is raising new questions about effective prevention, diagnosis and treatment.

27 Jun 2024

Fighting cancer with nanoparticles

Nanoparticles may be the future of the fight against pancreatic cancer, but also tumours that currently have no cure options. A video news release provides a synthesis of the ULISES project milestones.

27 Jun 2024

AI breakthrough: Speech analysis predicts Alzheimer's progression with 78.5% accuracy

A method for predicting Alzheimer’s disease (AD) progression.

27 Jun 2024

Diabetes decoded: How your gut microbiome influences disease risk

How microbial features and functions specific to subspecies and strains contribute to the pathological mechanisms of type 2 diabetes.

27 Jun 2024

New electrospinning innovations transform wearable and implantable medical devices

In a groundbreaking advancement that could reshape the landscape of precise medicine, researchers from the Beijing Institute of Technology and Rutgers University have unveiled a series of innovative electrospinning techniques capable of significantly enhancing the functionality and effectiveness of medical devices. This pioneering study, recently published in the Cyborg Bionic Systems journal, promises to revolutionize the creation and implementation of nano/microrobots, wearable/implantable biosensors, and organ-on-chip systems.

27 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

UCL researchers highlight the growing role of cardiovascular health in dementia risk

Dementia risk factors associated with cardiovascular health may have increased over time compared to factors such as smoking and having less education, finds a new study led by UCL researchers.

26 Jun 2024

CRISPR-based genetic technique eradicates malaria mosquitoes with over 99% efficiency

Scientists at the University of California have developed a precision-guided sterile insect technique to eliminate Anopheles gambiae mosquitoes, achieving over 99.5% male sterility and 99.9% female lethality, effectively suppressing malaria transmission.

26 Jun 2024

Duke researchers discover drug to restore aged livers

While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure.

26 Jun 2024

Novel approach can make many more bacteria amenable to genetic engineering

Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species.

26 Jun 2024

Hybrid schistosomes from cattle complicate human disease control

Effective control of bovine schistosomiasis will be required to meet disease elimination targets in humans, new research shows.

26 Jun 2024

Scale Biosciences announces ScalePlex technology to simplify single cell genomics studies of any scale

Novel multiplexing technology enables seamless sample pooling facilitating cost-efficient single cell experiments for compound screening and translational research.

26 Jun 2024

Study offers insights into gut microbiome diversity and type 2 diabetes risk

Brigham, Broad and Harvard Chan School researchers found that specific species and strains of bacteria were linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes.

26 Jun 2024

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Type-2 helper T (Th2) cells play intricate roles in the inflammatory response underlying asthma. Elevated levels of the protein GATA3 stimulate the maturation of these cells. Consequently, gene regions known as enhancers, which enhance the expression of the GATA3 gene, have been implicated in asthma-associated inflammation.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Mouse models inform potential treatments for Fragile X, Phelan-McDermid syndromes

Studies of mouse models of Fragile X syndrome and Phelan-McDermid syndrome show that treatment with cannabidiol (CBD) and the diabetes drug metformin can alleviate behavioral difficulties, according to research presented today (Wednesday) at the Federation of European Neuroscience Societies (FENS) Forum 2024.

26 Jun 2024

Genetic News and Research

CHARMs: A new hope for prion disease therapy

Assessing clinical benefit and safety in trial waivers for treatment-refractory cancers

Math model suggests single-parent nursing evolved to fight off bad bacteria

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Uptick in early-onset gastrointestinal cancers raises the need for better prevention and diagnosis

Fighting cancer with nanoparticles

AI breakthrough: Speech analysis predicts Alzheimer's progression with 78.5% accuracy

Diabetes decoded: How your gut microbiome influences disease risk

New electrospinning innovations transform wearable and implantable medical devices

Researchers identify key players in abnormal bone differentiation

UCL researchers highlight the growing role of cardiovascular health in dementia risk

CRISPR-based genetic technique eradicates malaria mosquitoes with over 99% efficiency

Duke researchers discover drug to restore aged livers

Novel approach can make many more bacteria amenable to genetic engineering

Hybrid schistosomes from cattle complicate human disease control

Scale Biosciences announces ScalePlex technology to simplify single cell genomics studies of any scale

Study offers insights into gut microbiome diversity and type 2 diabetes risk

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Study provides resource for investigating diabetes-linked transcription factors

Mouse models inform potential treatments for Fragile X, Phelan-McDermid syndromes

Sequencing & Genomics: Elevating Science and Healthcare eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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