Adenosine News and Research

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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.

Intracellular ATP levels in the cortical neurons vary with sleep–wake states, animal study shows

It is assumed that the brain has homeostatic mechanisms to prevent the depletion of cellular energy, required for all cellular activities.

7 Oct 2020

New approach to reveal high-resolution protein structural details

The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential for life.

6 Oct 2020

Anti-sense agents suppress SARS-CoV-2 virus

Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

4 Oct 2020

Clover Biopharma's new trimeric subunit vaccine candidate prevents COVID-19 in monkeys

The vaccine candidate produced a high level of neutralizing antibodies in animal models. Rhesus macaques immunized with the vaccine candidate showed reduced viral loads in the lungs. The research is published on the preprint server bioRxiv.

28 Sep 2020

Anti-CD73 molecule CPI-006 activates B cell responses to SARS-CoV-2

As the COVID-19 pandemic continues to cause an immense impact across many parts of the world, the role played by immune responses is becoming more evident every day. A recent funded paper published on the preprint server medRxiv* in September 2020 reports the initiation of a Phase I trial of a drug that increases antibody and cell-mediated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

Researchers investigate the effects of endurance training on cellular respiration

In obese individuals, endurance exercise improves fitness and increases the number of mitochondria * and cellular respiration in skeletal muscles.

10 Sep 2020

Host gene editing main driving force of SARS-CoV-2 mutations

A new study published on the aRxiv preprint server in September 2020 shows that the host immune response, mediated by two RNA editors, causes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to adapt and change strain characteristics.

9 Sep 2020

Massive cellular energy audit identifies genes that drive energy production, consumption

TK Adenosine triphosphate, or ATP, is the cellular energy currency that is as valuable to the human body as the dollar is to the US economy.

28 Aug 2020

Inhibition of key receptor implicated in post-stroke damage and recovery

Many people who suffer a stroke are permanently disabled. Stroke remains the leading cause of long-term disability in the United States.

20 Aug 2020

Researchers identify new treatment for osteoarthritis

The study results revolve around the long-established idea that machines within animal and human cells turn the sugars, fats, and proteins we eat into energy used by the body's millions of cells.

10 Aug 2020

USF Health researchers develop new reporter mouse strain for identifying P2X2-expressing cells

Despite frequent news announcing "medical breakthroughs," advancements in biomedical and clinical science typically happen incrementally.

7 Aug 2020

UMass Amherst chemist and kinesiologist synthesize artificial fuel for muscle

A chemist and kinesiologist got on a bus, but this isn't the set-up to a joke. Instead, kinesiologist and lead author Ned Debold and chemist Dhandapani Venkataraman, "DV," began talking on their bus commute to the University of Massachusetts Amherst and discovered their mutual interest in how energy is converted from one form to another - for Debold, in muscle tissue and for DV, in solar cells.

14 Jul 2020

New discovery helps explain heart defects in Barth syndrome

The heart needs energy to pump blood. So, energy production defects in heart muscles result in a variety of cardiac diseases.

7 Jul 2020

NUS researchers discover protein that promotes cancer progression

Cancers arise when the genetic code of normal cells is altered, causing excessive growth. Researchers from the Cancer Science Institute of Singapore at the National University of Singapore have discovered a protein that drives the growth of cancers of the esophagus or liver by altering the genetic code in a novel way.

29 Jun 2020

Researchers discover receptor that makes mice strong and slim

Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects.

25 Jun 2020

New methods may contribute to future structure-based drug design

Many pharmaceuticals work by targeting what are known as "G-protein-coupled receptors". In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors.

24 Jun 2020

Researchers find prothrombotic antibodies in patients with COVID-19

Even as the COVID-19 pandemic continues to spread across the world, researchers are still trying to understand the many ways in which it can manifest and its pathogenesis. A new report published on the preprint server medRxiv* in June 2020 shows that one possible mechanism of disease in COVID-19 is the production of antiphospholipid antibodies.

19 Jun 2020

MGH researchers identify potential molecular targets for ALD drug development

Alcohol-related liver disease (ALD) is a deadly condition affecting more than 150 million people worldwide with no treatment available besides transplant.

19 May 2020

Study shows how RNA editing affects the replication of COVID-19 virus

Two human deaminase enzymes edit the RNA of the SARS-CoV-2 virus when it enters a patient's body, with implications for the evolution of the virus and the spread of the infection, according to a new study.

19 May 2020