Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

mRNA vaccine against novel coronavirus goes on a trial in Seattle

A clinical trial for a vaccine to protect against the novel coronavirus commenced this Monday in the U.S.. If successful, this could mean an end to the current global pandemic of COVID-19 infections, feel experts.

16 Mar 2020

Researchers engineer microparticles that show promise against transplant rejection

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own.

13 Mar 2020

Researchers prove the ability to grow human-derived blood vessels in a pig

A team of researchers at the University of Minnesota Medical School recently proved the ability to grow human-derived blood vessels in a pig--a novel approach that has the potential for providing unlimited human vessels for transplant purposes.

11 Mar 2020

Study: Death rates after liver transplantation drop by more than 50% in the UK

In the past two decades, death rates after liver transplantation have dropped by more than half in the UK, according to a recent analysis of almost 10,000 liver transplant recipients published in BJS (British Journal of Surgery).

4 Mar 2020

New inhalation therapy could relieve lung fibrosis in mice and rats

A new study published in the journal Nature Communications in February 2020 shows that secretions from stem cells in the lung can be utilized to nebulize injured lungs due to several types of lung fibrosis in rats and mice. This could well result in the development of less invasive and more effective therapies for lung fibrosis.

1 Mar 2020

Measles re-emerging globally

Measles is a common childhood illness but can cause more than a passing fever with rash. It could turn out to be a complicated and severe illness, warn doctors in a new paper published in February 2020 in the journal BMJ Case Reports.

17 Feb 2020

UCLA researcher designs ways for immune cells to 'outsmart' solid tumors

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.

16 Feb 2020

Sexual orientation affects skin cancer risk in the USA

A new study published in the journal JAMA Dermatology in February 2020 shows a higher rate of indoor tanning and a corresponding increase in skin cancer, among men with homosexual or bisexual preferences compared to heterosexual men.

12 Feb 2020

Promising HIV vaccine fails in a large-scale clinical trial

The human immune deficiency virus (HIV) is an infectious disease that can lead to immunosuppression called acquired immunodeficiency syndrome (AIDS). For decades, scientists race to discover a vaccine that can help prevent the spread of the virus. The latest trial testing a new experimental vaccine in South Africa end in disappointment after deeming ineffective in preventing infection.

4 Feb 2020

Harmful genetic mutations in healthy donors' stem cells may create problems in AML patients

A stem cell transplant - also called a bone marrow transplant - is a common treatment for blood cancers, such as acute myeloid leukemia.

16 Jan 2020

Study reveals cellular cross-talk between regulatory T cells and fibroblast cells in pancreatic cancer microenvironment

A multidisciplinary Michigan Medicine team is shedding new light on the role of regulatory T cells in pancreatic cancer - and, in mouse models, have uncovered a new potential target to improve immunotherapy approaches to the deadly disease.

9 Jan 2020

Health officials urge children to get flu jabs this season

The holiday season is just around the corner and so is the anticipated flu season, which is expected to be worse this year. Public health officials warn parents to vaccinate their children against the influenza virus in abundance of precaution and to prevent serious complications.

16 Dec 2019

Adding post-transplant chemotherapy to standard treatment improves remission of allogeneic transplant patients

Investigators in the Blood and Marrow Transplant Program at Rutgers Cancer Institute of New Jersey compared outcomes for patients having undergone allogeneic stem cell transplant when post-transplant cyclophosphamide (PCy, a type of chemotherapy) was added as part of standard treatment to prevent disease through an immune response (immunoprophylaxis) than if this standard treatment was given alone.

5 Dec 2019

New method for discovering potential cancer-treating compounds

A new study published in the journal Cell Reports reports a novel method by which antitumor drugs that focus on reawakening exhausted immune cells called cytotoxic T cells against cancer can be quickly identified. This could help treat a large subset of cancers that thrive because of their ability to suppress antitumor activity in T cells.

4 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Improving the efficiency of antiangiogenic and antifibrotic drug for treatment of lung cancer

The University of Barcelona and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer.

19 Nov 2019

Inhaled immunosuppressant could improve prognosis of lung transplant patients

University of Maryland School of Medicine researchers found that lung transplant recipients who had early signs of organ rejection could increase their chances of survival by using an inhaled form of the immunosuppression drug cyclosporine.

13 Nov 2019

Bio–nano interactions help kill deadly microbes

Nanotechnology has been part of the changing world today. Nanoparticles, for instance, can help make materials lighter and stronger. They have been widely used across several industries, such as computers and medical technology.

11 Nov 2019

Study provides first data on infectious risk in children exposed to non-TNFi biologics and tofacitinib

A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero.

10 Nov 2019

Extending Medicare coverage of transplant drugs would benefit patients, reduce healthcare costs

Extending Medicare coverage of transplant medications would benefit patients and reduce healthcare costs.

8 Nov 2019