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Researcher provides insight into how stress causes physical symptoms and disease

A Michigan State University researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.

10 Jan 2018

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

A new blood stabilization method, developed at the Massachusetts General Hospital Center for Engineering in Medicine, significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells (CTCs), living cancer cells carried in the bloodstream.

9 Jan 2018

Researchers develop novel organ-on-a-chip device that models atherosclerosis

When studying diseases or testing potential drug therapies, researchers usually turn to cultured cells on Petri dishes or experiments with lab animals, but recently, researchers have been developing a different approach: small, organ-on-a-chip devices that mimic the functions of human organs, serving as potentially cheaper and more effective tools.

2 Jan 2018

Cancer immunotherapy’s effectiveness may depend on patient’s genetic makeup

Cancer cells arise when DNA is mutated, and these cells should be recognized as "foreign" by the immune system. However, cancer cells have found ways to evade detection by the immune system.

15 Dec 2017

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

11 Dec 2017

Researchers identify risk factor for drug-induced skin disease in diabetic patients

Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs.

6 Dec 2017

Study identifies new role for stress receptor CRF1 expressed on mast cells

A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.

1 Dec 2017

German scientists develop new nuclear medicine test to identify kidney transplant infection

German scientists have developed a novel nuclear medicine test that can determine whether a kidney transplant patient has developed infection in the transplanted tissue.

8 Nov 2017

New research reveals possible therapeutic target for controlling inflammation in the brain

New research published online in the Journal of Leukocyte Biology showed for the first time that mature monocytes (a specific type of white blood cell) express the CXCR7 receptor on their surface.

3 Nov 2017

Early-warning blood biomarkers identified for lung damage

Blood biomarkers that predict accelerated loss of lung function have been identified in a study of fire-fighters who worked in the aftermath of the World Trade Center disaster.

3 Nov 2017

Blood biomarkers appear to be early-warning signal for lung problems in WTC-exposed firefighters

Blood biomarkers appear to be an early-warning signal for the accelerated loss of lung function and airway obstruction in firefighters who responded to the World Trade Center disaster, according to new research published online in the Annals of the American Thoracic Society.

3 Nov 2017

Study discovers new genetic risk loci linked to children's food allergies

What role do genes play in egg, milk, and nut allergies? A study published in Nature Communications, led by the Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, has found five genetic risk loci that point to the importance of skin and mucous membrane barriers and the immune system in the development of food allergies.

24 Oct 2017

CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line

The Cell and Gene Therapy Catapult today announced a non-exclusive licensing agreement to provide its clinical-grade induced Pluripotent Stem Cell line to Seattle based Universal Cells.

6 Oct 2017

Study reveals etosis phenomenon in human blood monocytes

A recent study published online in the Journal of Leukocyte Biology found the first clear demonstration of etosis in human blood monocytes, a type of immune cell.

1 Sep 2017

Study: People with shorter LTL have more benefits on cognition following lifestyle intervention

Is telomere length associated with the cognitive response to a lifestyle intervention? Supporting evidence from the FINGER trial.

29 Aug 2017

Protein that protects fetus during pregnancy could help treat atopic dermatitis

A protein which protects the fetus during pregnancy, HLA-G1, shows high potential for treating atopic dermatitis and other related diseases.

4 Aug 2017

Scientists uncover new genetic markers that predispose individuals to lupus

Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.

18 Jul 2017

New study suggests potential new therapeutic approach to septic shock recovery

A new study published online in the Journal of Leukocyte Biology suggests a new approach to treating patients with sepsis, one of the most frequent causes of morbidity and mortality in intensive care units.

1 Jun 2017

Overweight or obesity linked to increased risk for severe periodontitis

Being overweight or obese was linked with an increased likelihood of having poor oral health in a recent study.

17 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

Leukocyte News and Research

Researcher provides insight into how stress causes physical symptoms and disease

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

Researchers develop novel organ-on-a-chip device that models atherosclerosis

Cancer immunotherapy’s effectiveness may depend on patient’s genetic makeup

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Researchers identify risk factor for drug-induced skin disease in diabetic patients

Study identifies new role for stress receptor CRF1 expressed on mast cells

German scientists develop new nuclear medicine test to identify kidney transplant infection

New research reveals possible therapeutic target for controlling inflammation in the brain

Early-warning blood biomarkers identified for lung damage

Blood biomarkers appear to be early-warning signal for lung problems in WTC-exposed firefighters

Study discovers new genetic risk loci linked to children's food allergies

CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line

Study reveals etosis phenomenon in human blood monocytes

Study: People with shorter LTL have more benefits on cognition following lifestyle intervention

Protein that protects fetus during pregnancy could help treat atopic dermatitis

Scientists uncover new genetic markers that predispose individuals to lupus

New study suggests potential new therapeutic approach to septic shock recovery

Overweight or obesity linked to increased risk for severe periodontitis

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

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