Neurodegenerative Diseases News and Research

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New insights into coumarin-based MAO inhibitors for neurodegenerative diseases

Announcing a new publication for Acta Materia Medica journal. Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders.

27 Feb 2025

Scientists uncover how a sugar shield in brain blood vessels protects against aging and disease

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain barrier, leading to increased permeability, neuroinflammation, and cognitive decline in aging and neurodegenerative diseases.

27 Feb 2025

Organ aging measured by blood test may help predict age-related diseases

Our organs age at different rates, and a blood test determining how much they've each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study led by University College London (UCL) researchers.

26 Feb 2025

Antioxidant-enzyme interactions and their role in non-communicable diseases

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs).

21 Feb 2025

Blood test for Alzheimer’s could replace costly and invasive spinal taps

Researchers indicate that the Lumipulse p-tau217 assay may reduce over 50% of lumbar punctures performed for diagnosing Alzheimer's disease.

20 Feb 2025

JAX researchers identify key genetic factors influencing eye aging in mice

Vision changes are an inevitable part of aging, but why are some more susceptible to age-related eye diseases and why do some individuals experience more severe decline than others?

18 Feb 2025

Researchers identify MLC1 as potential target in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by the immune system. B cells, which are a type of white blood cell, play a role in the development of MS and are thus a target for therapies.

18 Feb 2025

Groundbreaking ALS platform trial accelerates research and drug testing

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with few treatment options. Since 2018, the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, has been working with national and international stakeholders to accelerate ALS research by launching the first platform trial in ALS to simultaneously test multiple drugs using shared trial infrastructure and placebo data.

17 Feb 2025

New gene switch may lead to precise treatments for metabolic diseases

ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin.

17 Feb 2025

New research sheds light on brain inflammation in Alzheimer's

Brain inflammation, while a crucial part of the body's immune response, takes on a detrimental role in Alzheimer's disease.

16 Feb 2025

New discovery on mitochondrial protein could transform Charcot-Marie-Tooth treatment

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause in the currently incurable neurological disease Charcot-Marie-Tooth (CMT).

14 Feb 2025

Study reveals brain circuit linked to human creativity

A new study led by researchers at Mass General Brigham suggests that different brain regions activated by creative tasks are part of one common brain circuit.

13 Feb 2025

UCLA team identifies brain rhythms linked to seizures in Alzheimer's

A UCLA Health research team has identified changes in brain rhythms that indicate seizure activity in Alzheimer's patients.

13 Feb 2025

New research advances understanding of Parkinson's disease stages

From a study that analyzed brain images of more than 2,500 people with Parkinson's disease in 20 different countries, scientists were able to identify patterns of neurodegeneration and create metrics for each of the five clinical stages of the disease.

12 Feb 2025