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Research shows "Alzheimer's in a dish" model can accelerate drug discovery

A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as "Alzheimer's in a dish," the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain over 10 to 13 years in just six weeks.

27 Nov 2024

New discovery in the peripheral nervous system could help control obesity

An international team of researchers has discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body.

25 Nov 2024

Researchers identify brain circuit behind sexual rejection in females

A team from the Champalimaud Foundation (CF) has pinpointed a critical neural circuit for sexual rejection, identifying a set of brain cells that play a crucial role in determining whether a female accepts or rejects mating attempts based on her reproductive cycle.

25 Nov 2024

Researchers develop new approach to effectively deliver therapeutics into the brain

Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach - demonstrated in mouse models and isolated human brain tissue - to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of neurological and psychiatric diseases.

25 Nov 2024

Study reveals how brainstem neurons control eye movements

Working with week-old zebrafish larva, researchers at Weill Cornell Medicine and colleagues decoded how the connections formed by a network of neurons in the brainstem guide the fishes' gaze.

22 Nov 2024

Advanced 3D brain models created to study memory and perception

The hippocampus is one of the most fascinating brain regions. Associated with the formation of memories, it also helps us to navigate through the world without getting lost.

22 Nov 2024

Psychedelics may offer anxiety relief through specific brain circuits

New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics.

15 Nov 2024

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR) - long studied primarily for its role in learning and memory - also plays a crucial role in stabilizing brain activity.

15 Nov 2024

UCLA researchers discover netrin1's unexpected role in spinal cord development

Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have uncovered an unexpected role for the molecule netrin1 in organizing the developing spinal cord.

15 Nov 2024

UCL scientists receive £78 million funding boost to develop treatment for motor neurone disease

A funding boost of more than £78 million will help UCL scientists working to develop a potential treatment for motor neurone disease, for which there is currently no cure and which affects 5,000 people each year in the UK.

14 Nov 2024

Exercise promotes nerve growth at the cellular level

There's no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

12 Nov 2024

Uncovering the pathway behind ALS neurodegeneration

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.

8 Nov 2024

Traditional Chinese herb shows promise against Alzheimer’s and Parkinson’s

Zizyphi spinosi semen demonstrates neuroprotective effects, improving cognitive function and reducing amyloid and tau pathology in models of aging and dementia.

8 Nov 2024

DEEPscope breaks barriers in deep-tissue brain imaging

Researchers at Cornell have unveiled an advanced imaging technology capable of unprecedented deep and wide-field visualization of brain activity at single-cell resolution.

6 Nov 2024

Saturated fats accelerate neurodegeneration in multiple sclerosis

Targeting ceramide synthase enzymes may reduce multiple sclerosis severity by limiting ceramide C16 synthesis, offering potential neuroprotective strategies.

6 Nov 2024

New Alzheimer's guidelines focus on risk, not diagnosis, in healthy adults

Researchers from the International Working Group recommend categorizing biomarker-positive, cognitively normal individuals as "at risk" for Alzheimer's to avoid unnecessary diagnoses and emphasize preventive care.

4 Nov 2024

New model sheds light on APOE4's role in Alzheimer's pathology

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein - the most important genetic risk factor for Alzheimer's disease - the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

4 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

Research identifies crucial links between dietary choices and progression of multiple sclerosis

Newly published research in the journal Glia has identified crucial links between dietary choices and the progression of multiple sclerosis (MS).

1 Nov 2024

Study links brain proteins to individual differences in functional connectivity

A long-standing goal of neuroscience is to understand how molecules and cellular structures on a microscale give rise to communication between brain regions at the macroscale.

1 Nov 2024