RNA Sequencing News and Research

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Early cholesterol spikes fuel atherosclerosis by altering macrophages

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

6 Sep 2024

Hybrid neuron-glia cells found in glioma may impact tumor growth

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have uncovered a new cell type in the human brain.

5 Sep 2024

Review explores WNT5B and WNT10B roles in osteosarcoma

A new review was published in Oncotarget's Volume 15 on August 2, 2024, entitled, "Targeting WNT5B and WNT10B in osteosarcoma."

4 Sep 2024

Scientists uncover shared gene expression patterns in aging and psychiatric disorders

Researchers reveal how aging and psychiatric disorders converge at the cellular level in the orbitofrontal cortex, identifying key gene expression changes that could lead to new therapies.

4 Sep 2024

CD4 T cells found to be key players in tuberculosis defense

The body's first line of defense against tuberculosis (TB) involves immune cells that suppress lung inflammation instead of activating it, reported University of Pittsburgh and the Ragon Institute of Mass General, MIT, and Harvard scientists today in Immunity.

29 Aug 2024

Study reveals key role of A20 protein in controlling inflammation in liver disease

Many individuals worldwide suffer from chronic liver disease (CLD), which poses significant concerns for its tendency to lead to hepatocellular carcinoma or liver failure. CLD is characterized by inflammation and fibrosis.

29 Aug 2024

New insights into AD pathogenesis and treatment

The main text of the study details the experiments conducted to understand the role of IL-24 in AD-like conditions. It describes the methods used, including single-cell RNA sequencing, and the animal models employed to mimic AD. The findings indicate that MRSA infection leads to increased IL-24 in keratinocytes, which in turn heightens type 2 immune responses and worsens AD symptoms.

29 Aug 2024

Study reveals a new target for universal treatment for autoimmune diseases

More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was at Harvard, discovered a type of T cell in humans that suppresses the immune system; they later found that these so-called regulatory T cells, when defective, are an underlying cause of autoimmune disease, specifically multiple sclerosis (MS).

28 Aug 2024

Researchers identify key cellular interactions driving Alzheimer's and aging

An analysis of more than 1.6 million brain cells from older adults has captured the cellular changes that occur in the early stages of Alzheimer's disease, potentially revealing new routes for preventing the most common cause of dementia in older individuals.

28 Aug 2024

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

Engineered human cardiac tissue reveals how lupus autoantibodies damage the heart

Study demonstrates that autoantibodies in systemic lupus erythematosus (SLE) patients contribute to myocardial injury by binding to and impairing stressed cardiac cells, offering insights into potential therapeutic targets.

25 Aug 2024

New analytical method for identifying cancer cell targets

What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies. Scientists from the German Cancer Research Center (DKFZ) and the NCT Heidelberg are publishing a highly sensitive method based on mass spectroscopy to identify such tumor-specific "neoepitopes". The analytical method is designed to detect these low-abundance protein fragments and requires minimal amounts of sample material.

23 Aug 2024

New tool could revolutionize cardiovascular risk management: PRESS score validated

The association between platelet hyperreactivity and the risk of cardiovascular events.

22 Aug 2024

Common fatty acid could improve treatment of recurrent bacterial vaginosis infections

Researchers investigated oleic acid as a potential treatment to inhibit Lactobacillus iners dominance in bacterial vaginosis.

22 Aug 2024

Spatial transcriptomics unlocks malaria's liver stage secrets

For the malaria parasite to reach the blood of its human host, it must first enter the liver, where only a small number of parasites differentiate and replicate for upwards of seven days, making it a bottleneck in the parasite's lifecycle. This bottleneck makes the liver stage an optimal target for effective and long-lasting vaccines against the disease. Using Spatial Transcriptomics and single-cell RNA-sequencing technologies, researchers at Stockholm University have for the first time managed to create a spatio-temporal map of malaria infection in the mouse liver. A study that was recently published in Nature Communications.

21 Aug 2024

How the MIND diet may protect against dementia

Researchers utilize transcriptomic data to examine the protective effects of the MIND diet in reducing the risk of dementia and slowing cognitive decline.

20 Aug 2024

Study uncovers oleic acid's role in restoring vaginal microbial balance in bacterial vaginosis

More than half of women globally experience bacterial vaginosis (BV) - an imbalance of naturally occurring microbes in the female genital tract - at least once in their life.

19 Aug 2024

Lexogen Launches RiboCop rRNA Depletion Kit for Fish Species

Lexogen, a leader in RNA sequencing technologies, is thrilled to announce the launch of the RiboCop rRNA Depletion Kit for Fish, a dedicated solution to facilitate transcriptome analysis of fish species by effectively removing unwanted ribosomal RNA (rRNA) from total RNA samples.

From Lexogen 19 Aug 2024

New RNA molecules in extracellular vesicles could transform cancer diagnosis

Scientists at the Icahn School of Medicine at Mount Sinai have identified a new class of RNAs packed into tiny particles known as extracellular vesicles (EVs) that could revolutionize how cancer and other diseases are diagnosed.

16 Aug 2024

Quantum leap in single cell genomics: Scale Bio launches groundbreaking ‘100 Million Cell Challenge’ in collaboration with Ultima Genomics and NVIDIA

Scale Biosciences (Scale Bio), a leader in innovative and scalable single cell analysis solutions, today announced the launch of the “100 Million Cell Challenge,” a global initiative aimed at pushing the boundaries of single-cell genomics research.

16 Aug 2024

RNA Sequencing News and Research

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Hybrid neuron-glia cells found in glioma may impact tumor growth

Review explores WNT5B and WNT10B roles in osteosarcoma

Scientists uncover shared gene expression patterns in aging and psychiatric disorders

CD4 T cells found to be key players in tuberculosis defense

Study reveals key role of A20 protein in controlling inflammation in liver disease

New insights into AD pathogenesis and treatment

Study reveals a new target for universal treatment for autoimmune diseases

Researchers identify key cellular interactions driving Alzheimer's and aging

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

Engineered human cardiac tissue reveals how lupus autoantibodies damage the heart

New analytical method for identifying cancer cell targets

New tool could revolutionize cardiovascular risk management: PRESS score validated

Common fatty acid could improve treatment of recurrent bacterial vaginosis infections

Spatial transcriptomics unlocks malaria's liver stage secrets

How the MIND diet may protect against dementia

Study uncovers oleic acid's role in restoring vaginal microbial balance in bacterial vaginosis

Lexogen Launches RiboCop rRNA Depletion Kit for Fish Species

New RNA molecules in extracellular vesicles could transform cancer diagnosis

Quantum leap in single cell genomics: Scale Bio launches groundbreaking ‘100 Million Cell Challenge’ in collaboration with Ultima Genomics and NVIDIA

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