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UCL researchers measure mass of human chromosomes with X-rays for the first time

The mass of human chromosomes, which contain the instructions for life in nearly every cell of our bodies, has been measured with X-rays for the first time in a new study led by UCL researchers.

1 Jun 2021

Study supports the need for improving early TB diagnosis and care in Irish prisons

Investigators from Trinity College Dublin, the Irish Mycobacteria Reference Laboratory, St James's Hospital, and the Department of Public Health HSE East believe tuberculosis (TB) care in Irish Prisons should be supported, considering the findings of their study which is published today (Tuesday, 1st June, 2021) in the International Journal of Tuberculosis and Lung Disease.

1 Jun 2021

New initiative to reduce treatment delays for patients with rare diseases

The Treatabolome project is a research initiative to develop a freely available, interoperable online platform dedicated to disseminating rare disease and gene-specific treatment information to healthcare professionals regardless of their level of specialized expertise.

1 Jun 2021

New genetic resource may lead to prevention and treatment strategies for malaria

A new extensive genetic resource of rat-infecting malaria parasites may help advance the development of malaria prevention and treatment strategies.

1 Jun 2021

Ethnic diversity in genetic study identifies more genomic regions linked to type 2 diabetes-related traits

By ensuring ethnic diversity in a largescale genetic study, an international team of researchers, including a University of Massachusetts Amherst genetic epidemiologist, has identified more regions of the genome linked to type 2 diabetes-related traits.

1 Jun 2021

New method helps identify rare genetic disease that affects brain development

Rare disease experts detail the first results of an unprecedented collaboration to diagnose people living with unsolved cases of rare diseases across Europe.

1 Jun 2021

AMSBIO's custom lentivectors for labeling organoids

AMSBIO have supplied custom lentivectors to Francesco Pampaloni and his team at the Buchmann Institute for Molecular Life Sciences in Frankfurt, Germany allowing them to visualize cell nuclei and F-actin cytoskeleton in their organoids.

From AMS Biotechnology 1 Jun 2021

SARS-CoV-2 variants have higher transmissibility and a longer infectious period

Researchers analyzed data on three variants of concern and found that viral loads were higher and infection lasted longer for the B.1.1.7 variant. They all were more infectious than the original strain, and transmissibility also depended on population demographics.

31 May 2021

Report on the effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in Canada

The report has recently been published on the preprint server medRxiv* by Kwong et al. (May 28th, 2021) and focused on the Pfizer-BioNTech or Moderna vaccines, confirming the supposed greater efficacy in preventing infection or severe outcomes following the administration of two doses.

31 May 2021

Ethnic diversity in genetic study of glycemic traits yields better results

By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone.

31 May 2021

Expanding genomic research into different ancestries yields more and better results

Today The Lundquist Institute announced that its investigators contributed data from several studies, including data on Hispanics, African-Americans and East Asians, to the international MAGIC collaboration, composed of more than 400 global academics, who conducted a genome-wide association meta-analysis led by the University of Exeter.

31 May 2021

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

An interesting new study by researchers at the University of Portsmouth, UK, describes the use of a mathematical method to sequence genomes based on information theory. The method offers an alternative to clinical techniques, allowing mutations to be detected and possibly even predicted. In this way, it opens new research opportunities in bioinformatics and genetics.

31 May 2021

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 has a single-stranded RNA genome encoding both structural and non-structural proteins. Of these, the latter is known to play a variety of roles in viral replication and the assembly of new viral particles, as well as in suppressing cellular immune responses. A new study reports the activity of one such protein, the non-structural protein 14 (NSP14), which activates the inflammatory mediator NF-κB to trigger intense inflammation.

31 May 2021

SARS-CoV-2 genome mutations display convergent evolution indicating strong adaptive advantages

A recent report by a team of researchers focused on the extent of convergent evolution in the SARS-CoV-2 spike (S) protein. The report confirms that top SARS-CoV-2 lineages of concern have the most convergent spike protein mutations. This indicates their fundamental adaptive advantage.

31 May 2021

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Researchers at the Southern University of Science and Technology in China revealed rapid and dramatic changes in quasispecies diversity upon evaluating the SARS-CoV-2 populations present in the upper and lower respiratory tracts of patients with varying COVID-19 severity.

31 May 2021

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

The study, published in the journal Phytomedicine, characterized an active compound, corilagin (a derivative from Phyllanthus urinaria), as potential SARS-CoV-2 entry inhibitors for its preventive application in daily antiviral hygiene products.

31 May 2021

Study could help identify risk of secondary leukaemia in certain children

Scientists from the Wellcome Sanger Institute and the University of Cambridge found that in children with neuroblastoma - a cancer of immature nerve cells - treatment with platinum chemotherapy caused changes to the genome that could then cause leukaemia in some children later on.

31 May 2021

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

While DNA is often idealized as the "molecule of life", it is also a highly sophisticated polymer that can be used for next-generation materials. Beyond the fact that it can store information, further fascinating aspects of DNA are its geometric and topological properties, such as knotting and super-coiling.

31 May 2021

New genetic editing tools could stop the spread of mosquito diseases

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

29 May 2021

Study provides new insights into the origins of genetic disorders

New insights into the ability of DNA to overcome harmful genetic changes have been discovered by scientists at the Wellcome Sanger Institute, the University of Lausanne and their collaborators.

29 May 2021

Genome News and Research

UCL researchers measure mass of human chromosomes with X-rays for the first time

Study supports the need for improving early TB diagnosis and care in Irish prisons

New initiative to reduce treatment delays for patients with rare diseases

New genetic resource may lead to prevention and treatment strategies for malaria

Ethnic diversity in genetic study identifies more genomic regions linked to type 2 diabetes-related traits

New method helps identify rare genetic disease that affects brain development

AMSBIO's custom lentivectors for labeling organoids

SARS-CoV-2 variants have higher transmissibility and a longer infectious period

Report on the effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in Canada

Ethnic diversity in genetic study of glycemic traits yields better results

Expanding genomic research into different ancestries yields more and better results

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 genome mutations display convergent evolution indicating strong adaptive advantages

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

Study could help identify risk of secondary leukaemia in certain children

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

New genetic editing tools could stop the spread of mosquito diseases

Study provides new insights into the origins of genetic disorders

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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