Preclinical News and Research

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Review of haemodynamics in stent development shows spiral flow may be key to improving peripheral arterial stent performance

Vascular Flow Technologies, the medical device company using proprietary Spiral Laminar Flow (SLF™) technology to replicate natural blood flow for enhanced patient outcomes, today announces that 'Haemodynamics and Flow Modification Stents for Peripheral Arterial Disease: A Review’, co-authored by VFT’s non-executive Medical Director Graeme Houston, has been published in the Annals of Biomedical Engineering. The paper reviews the importance of haemodynamics in stent development as a method of improving patency and longevity of the stent.

4 Nov 2015

Approval to start trial of Videregen's replacement trachea technology

The INSPIRE consortium, led by Videregen Ltd, has received approval from the MHRA1 to start a UK clinical trial with its tissue engineered replacement trachea.

3 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

CureVac raises €100M to enable rapid expansion of mRNA development platform, clinical-stage pipeline

CureVac, a clinical-stage biopharmaceutical company pioneering the field of mRNA-based technology, today announces that it has raised about $110 million (€100 million) to enable accelerated expansion of its industry-leading messenger RNA (mRNA) development platform and clinical-stage pipeline.

3 Nov 2015

Rheumatoid arthritis significantly increases risk of death due to cardiovascular causes

Rheumatoid arthritis (RA) has been associated with increased risk of death in the past, but a new study by investigators from Brigham and Women's Hospital brings that risk into sharper focus. Using data from the Nurses' Health Study, which has followed more than 100,000 female registered nurses since 1976, researchers found that rheumatoid arthritis significantly increased participants' overall risk of death, especially risk of death due to respiratory or cardiovascular causes.

3 Nov 2015

New initiative launched to accelerate search for effective HIV vaccine

A new 23 million euro initiative to accelerate the search for an effective HIV vaccine begins today. Financed by the European Commission, the European AIDS Vaccine Initiative (EAVI2020) brings together leading HIV researchers from public organisations and biotech companies from across Europe, Australia, Canada and the USA in a focused effort to develop protective and therapeutic HIV vaccines.

2 Nov 2015

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

Small U.S.-based companies developing countermeasures to protect healthy tissue from the effects of radiation exposures may be eligible for a unique funding opportunity offered through the National Space Biomedical Research Institute. NSBRI's Industry Forum is soliciting applications for its Space Medical and Related Technologies Commercialization Assistance Program (SMARTCAP).

31 Oct 2015

New campaign raises awareness of City of Hope's life-saving mission and impact

Imagine being diagnosed with one of the most rare and aggressive forms of breast cancer, given a five percent chance to live and told having children will never be an option. Southern California local Kommah McDowell was told just that— and then she went to City of Hope.

31 Oct 2015

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California, San Diego researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half.

31 Oct 2015

World’s first mini synchrotron inaugurated at Technical University of Munich

For some years now it has been possible to generate high-brilliance X-rays using ring-shaped particle accelerators. However, such installations are several hundred meters in diameter and cost billions of euros.

31 Oct 2015

First patient of U.S. phase 1 trial treated with Genticel’s GTL001 candidate for HPV 16/18 infections

Genticel, a clinical-stage biotechnology company and developer of innovative immunotherapies to prevent cancers caused by the human papillomavirus, today announces that the first patient of the U.S. phase 1 clinical trial has been vaccinated with GTL001, the company’s first-in-class therapeutic vaccine candidate against HPV 16/18 infections.

31 Oct 2015

Ultragenyx, Arcturus sign agreement to develop mRNA therapeutics to certain rare diseases

Ultragenyx Pharmaceutical Inc., a biopharmaceutical company focused on the development of novel products for rare and ultra-rare diseases, and Arcturus Therapeutics, Inc., a leading RNA medicines company, today announced that they have entered into a research collaboration and license agreement to discover and develop messenger RNA (mRNA) therapeutics to certain rare disease targets using Arcturus' UNA Oligomer chemistry and LUNAR nanoparticle delivery platform.

29 Oct 2015

Pre-clinical study demonstrates positive effects of advanced prebiotic on neuro-inflammation, anxiety

Clasado Biosciences Limited, the producers and suppliers of the second generation prebiotic Bimuno(R) (B-GOS), a unique trans-galactooligosaccharide, and the Department of Psychiatry, University of Oxford, today announce the results of their latest pre-clinical study demonstrating a major role of the unique carbohydrate complex Bimuno against neuro-inflammation and anxiety.

28 Oct 2015

Biodegradable polymer could help heal the bones of patients with orthopedic injuries

A plastic derived from cornstarch combined with a volcanic ash compound, Montmorillonite clay, could help heal the bones of hundreds of thousands of patients with orthopedic injuries who need bone replacement after tumor removal, spinal fusion surgery or fracture repair.

28 Oct 2015

Research provides novel insight into potential new therapeutic targets for triple-negative breast cancer

Recent laboratory findings provide novel insight into potential new therapeutic approaches for triple-negative breast cancer, a particularly difficult to treat and aggressive form of the disease.

28 Oct 2015

Genetic discovery sheds light on how prostate cancer develops and spreads

A new and important genetic discovery, which sheds light on how prostate cancers develop and spread, has been made by an international research team led by scientists at The University of Nottingham.

27 Oct 2015

Sinovac Dalian receives approval to start human clinical trials of varicella vaccine candidate

Sinovac Biotech Ltd., a leading provider of biopharmaceutical products in China, today announced that one of its subsidiaries, Sinovac Dalian, has received approval to begin human clinical trials on its varicella vaccine candidate. The clinical trial application for the varicella vaccine was officially accepted by the China Food and Drug Administration in January 2013.

26 Oct 2015

Early trial results in lung cancer

Results from early phase trials investigating different therapeutic agents in lung cancer patients were presented during the third Presidential Session at the European Cancer Congress in Vienna, Austria. Here we summarise two studies reported at the session.

22 Oct 2015

Breakthrough research suggests that female sex hormone may save lives on the battlefield

Breakthrough research suggests a female sex hormone may be the key to saving lives on the battlefield, where between 2001 and 2011 more than 80 percent of potentially preventable U.S. war injury deaths resulted from blood loss.

22 Oct 2015

First patients receive doses of antisense drug for Huntington's disease

The first few patients have received doses of an experimental RNA-targeting drug for Huntington's disease, it was announced today.

20 Oct 2015

Preclinical News and Research

Review of haemodynamics in stent development shows spiral flow may be key to improving peripheral arterial stent performance

Approval to start trial of Videregen's replacement trachea technology

Patients with Down syndrome face additional challenge of early-onset dementia

CureVac raises €100M to enable rapid expansion of mRNA development platform, clinical-stage pipeline

Rheumatoid arthritis significantly increases risk of death due to cardiovascular causes

New initiative launched to accelerate search for effective HIV vaccine

Unique funding opportunity seeks countermeasures to protect healthy tissue from radiation exposure

New campaign raises awareness of City of Hope's life-saving mission and impact

UCSD researchers develop new computational strategy to find tumor-shrinking molecules

World’s first mini synchrotron inaugurated at Technical University of Munich

First patient of U.S. phase 1 trial treated with Genticel’s GTL001 candidate for HPV 16/18 infections

Ultragenyx, Arcturus sign agreement to develop mRNA therapeutics to certain rare diseases

Pre-clinical study demonstrates positive effects of advanced prebiotic on neuro-inflammation, anxiety

Biodegradable polymer could help heal the bones of patients with orthopedic injuries

Research provides novel insight into potential new therapeutic targets for triple-negative breast cancer

Genetic discovery sheds light on how prostate cancer develops and spreads

Sinovac Dalian receives approval to start human clinical trials of varicella vaccine candidate

Early trial results in lung cancer

Breakthrough research suggests that female sex hormone may save lives on the battlefield

First patients receive doses of antisense drug for Huntington's disease

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