Clinical Trial News and Research

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Small NIH clinical trial shows that new monoclonal antibody can prevent malaria

One dose of a new monoclonal antibody discovered and developed at the National Institutes of Health safely prevented malaria for up to nine months in people who were exposed to the malaria parasite.

11 Aug 2021

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

Scientists from Germany and Belgium have recently described the immunogenicity of a plant-based virus-like particle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine induces robust antibody and T cell responses for at least 6 months. Moreover, the vaccine demonstrates potent neutralizing efficacy against the B.1.1.7, B.1.351, and P1 variants of SARS-CoV-2.

11 Aug 2021

Adolescent and young adult cancer patients found to be well represented in NCI-sponsored clinical trials

Adolescent and young adult (AYA) patients with cancer have not seen the same improvements in survival over the years as their pediatric and older adult counterparts.

10 Aug 2021

Penn study discovers a targetable vulnerability in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) cells can be destroyed and kept from multiplying by inhibiting the HDL cholesterol receptor SCARB1, according to research from the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2021

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

Children's Hospital Colorado today announced it has joined the Xplore2/Pivotal trial, and is actively enrolling patients for the first-ever pivotal trial of a synthetic restorative pulmonary valve.

9 Aug 2021

Women underrepresented in cardiovascular clinical trials despite guidelines and legal requirements

Women remain underrepresented in cardiovascular clinical trials despite guidelines and legal requirements developed almost 30 years ago to ensure broader inclusivity, according to a report from the American College of Cardiology Cardiovascular Disease in Women Committee published today in the Journal of the American College of Cardiology.

9 Aug 2021

New study shows how quickly vaping can affect the cells of healthy younger nonsmokers

The risk that both tobacco and electronic cigarettes can pose to regular smokers' health has been well documented, but a new UCLA study illustrates just how quickly vaping can affect the cells of even healthy younger nonsmokers.

9 Aug 2021

Dileucine more effective than leucine in stimulating muscle-building in humans

In a randomized control study of 10 healthy young men, researchers compared how consuming the single amino acid leucine or its two-molecule equivalent, dileucine, influenced muscle-building and breakdown.

9 Aug 2021

Quanterix Simoa® Technology Powers Breakthrough Alzheimer’s Disease Research Presented by Eli Lilly and Company at Alzheimer’s Association International Conference (AAIC) 2021

Ultra-sensitive Simoa® HD-X technology powers new findings that detect rapid reduction of plasma P-tau217 from donanemab, Lilly’s investigational antibody therapy for Alzheimer's disease at 12 weeks

From Quanterix 9 Aug 2021

New immunotherapy strategy can eliminate pancreatic tumors in mice

Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years.

6 Aug 2021

Study examines the effect of vitamin D supplementation on kidney health in adults with prediabetes

A recent clinical trial described in CJASN has examined the potential of vitamin D supplementation for protecting the kidney health of individuals with pre-diabetes.

6 Aug 2021

Scientists use AI to identify new biomarkers for breast cancer

Scientists at Case Western Reserve University have used Artificial Intelligence (AI) to identify new biomarkers for breast cancer that can predict whether the cancer will return after treatment - and which can be identified from routinely acquired tissue biopsy samples of early-stage breast cancer.

6 Aug 2021

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma.

6 Aug 2021

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

A new policy report released today by the global non-profit research and development organization Drugs for Neglected Diseases initiative (DNDi) highlights how the development of therapeutics has been relatively neglected in the global response to COVID-19 and warns that with the few treatment innovations available principally in high-income countries, we risk repeating history and replicating the vaccine inequality that has become a defining characteristic of this global pandemic.

6 Aug 2021

Review highlights barriers to recruiting women into cardiovascular trials and offers solutions

Women must be equally represented in heart disease research to ensure that treatment recommendations meet their specific health needs, according to a report published today in European Heart Journal, a journal of the European Society of Cardiology (ESC).

6 Aug 2021

Using circulating tumor DNA to detect urothelial cancer relapse could help improve treatment

Using circulating tumor DNA to identify patients at risk of urothelial cancer relapse after surgical resection could help improve post-surgery treatment.

6 Aug 2021

Full dose anticoagulation with heparin improves outcomes for moderately ill COVID-19 patients

Collaborative international clinical trials testing full dose anticoagulation with heparin (a blood thinner) in both moderately ill and critically ill patients has found the treatment improves outcomes and reduces the need for vital organ support such as mechanical ventilation in moderately ill patients.

6 Aug 2021

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Shuo Ma, MD, '00 PhD, associate professor of Medicine in the Division of Hematology and Oncology, was co-first author of the clinical trial published in Blood.

5 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

Experimental drug combination extends survival in mice with lung cancer, study finds

A combination of experimental drugs increased the attack of immune cells on non-small cell lung cancer (NSCLC) to extend survival in mice, a new study found.

5 Aug 2021

Clinical Trial News and Research

Small NIH clinical trial shows that new monoclonal antibody can prevent malaria

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

Adolescent and young adult cancer patients found to be well represented in NCI-sponsored clinical trials

Penn study discovers a targetable vulnerability in clear cell renal cell carcinoma

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

Women underrepresented in cardiovascular clinical trials despite guidelines and legal requirements

New study shows how quickly vaping can affect the cells of healthy younger nonsmokers

Dileucine more effective than leucine in stimulating muscle-building in humans

Quanterix Simoa® Technology Powers Breakthrough Alzheimer’s Disease Research Presented by Eli Lilly and Company at Alzheimer’s Association International Conference (AAIC) 2021

New immunotherapy strategy can eliminate pancreatic tumors in mice

Study examines the effect of vitamin D supplementation on kidney health in adults with prediabetes

Scientists use AI to identify new biomarkers for breast cancer

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

Review highlights barriers to recruiting women into cardiovascular trials and offers solutions

Using circulating tumor DNA to detect urothelial cancer relapse could help improve treatment

Full dose anticoagulation with heparin improves outcomes for moderately ill COVID-19 patients

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Experimental drug combination extends survival in mice with lung cancer, study finds

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