Efficacy News and Research

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NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

In a recent study posted to the bioRxiv* preprint server, researchers at the U.S National Institutes of Health demonstrated the efficacy of molnupiravir and nirmatrelvir, two oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals in the rhesus macaque model, the closest proxy to humans.

7 Sep 2022

Techniques used for SARS-CoV-2 detection in body fluids

In a recent review published in the journal Trends in Analytical Chemistry, researchers provided a comprehensive overview of the current techniques used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in bodily fluids.

7 Sep 2022

The associations between vaccination status, type, and time since vaccination with lineage identity during the emergence of new SARS-CoV-2 variants

Researchers assessed the association between SARS-CoV-2 strains and patient age, COVID-19 vaccination status, vaccine type, and days elapsed since the most recent vaccination among New York residents.

7 Sep 2022

Is male hypogonadism a risk factor for hospitalization for COVID-19?

Researchers found an association between male hypogonadism and hospitalization risk for COVID-19.

7 Sep 2022

Review explores the involvement of the endothelium as an important underpinning of long COVID’s pathophysiology

Researchers discussed possible mechanisms and potential treatment methods for endotheliopathy observed in patients with post-acute sequelae of SARS-CoV-2 infection.

6 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

A new study published in the Viruses journal aimed to investigate the cross-reactivity of VACV-based vaccines against the MPXV viruses responsible for the 2022 outbreak.

5 Sep 2022

Combined stem cell and gene therapy shows promise to treat patients with ALS

Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier.

5 Sep 2022

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Announcing a new article publication from Acta Pharmaceutica Sinica B. Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies.

5 Sep 2022

Recent advances in nano-based therapeutic strategies for the treatment of infectious lung diseases

Announcing a new publication for Acta Materia Medica journal. Infectious lung diseases are inflammatory diseases of the lungs caused by infectious agents such as bacteria, viruses or fungi.

5 Sep 2022

Are current COVID-19 vaccines in England effective against severe BA.4 and BA.5 Omicron sub-lineage infections?

Researchers investigated the vaccine efficacy of various COVID-19 vaccines against the BA.2, BA.4, and BA.5 sub-lineages of the SARS-CoV-2 Omicron variant.

5 Sep 2022

Sensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and sera

Researchers assessed the sensitivity of the SARS-CoV-2 Omicron subvariant BA.2.75 spike protein to neutralization by monoclonal antibodies and sera obtained from Swedish individuals.

5 Sep 2022

What is the impact of inter-individual heterogeneity on the degree and duration of vaccinal protection against mild and severe COVID-19?

Researchers suggested ways to address heterogeneity in immune responses conferred by COVID-19 vaccines.

5 Sep 2022

Researchers compare the percent excess mortalities due to the zero-COVID-19 policy or the living-with-COVID policy

Researchers compared the percent excess mortalities due to the zero-COVID-19 policy or the living-with-COVID policy.

5 Sep 2022

AI model detects COVID-19 infection in people’s voices

Artificial intelligence (AI) can be used to detect COVID-19 infection in people's voices by means of a mobile phone app, according to research to be presented on Monday at the European Respiratory Society International Congress in Barcelona, Spain.

5 Sep 2022

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

A new study determines the antiviral efficacy of favipiravir against ZIKV and SARS-CoV-2 infections.

4 Sep 2022

MHRA approves bivalent COVID-19 booster vaccine made by Pfizer/BioNTech

A second, "bivalent" vaccine has today been approved as a booster by the Medicines and Healthcare products Regulatory Agency (MHRA) after it was found to meet the UK regulator's standards of safety, quality and effectiveness.

3 Sep 2022

Male hypogonadism associated with risk of hospitalization for COVID-19

Men with low testosterone levels are more likely to require hospitalization after COVID-19 infection than men with normal levels or those on testosterone therapy, according to Saint Louis University School of Medicine and Washington University School of Medicine in St. Louis researchers.

2 Sep 2022

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

2 Sep 2022

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

This prespecified subgroup analysis of East Asian adults who participated in a phase 3 clinical trial of belimumab added to standard therapy vs. placebo added to standard therapy for lupus nephritis shows earlier and more sustained improvement in kidney outcomes with the addition of belimumab.

2 Sep 2022

Efficacy News and Research

NIH animal study combines Paxlovid with Lagevrio against SARS-CoV-2 Delta

Techniques used for SARS-CoV-2 detection in body fluids

The associations between vaccination status, type, and time since vaccination with lineage identity during the emergence of new SARS-CoV-2 variants

Is male hypogonadism a risk factor for hospitalization for COVID-19?

Review explores the involvement of the endothelium as an important underpinning of long COVID’s pathophysiology

Auranofin inhibits SARS-CoV-2 replication

Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak

Combined stem cell and gene therapy shows promise to treat patients with ALS

Targeting Gαq/11 may be an efficient therapeutic strategy against uveal melanoma

Recent advances in nano-based therapeutic strategies for the treatment of infectious lung diseases

Are current COVID-19 vaccines in England effective against severe BA.4 and BA.5 Omicron sub-lineage infections?

Sensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and sera

What is the impact of inter-individual heterogeneity on the degree and duration of vaccinal protection against mild and severe COVID-19?

Researchers compare the percent excess mortalities due to the zero-COVID-19 policy or the living-with-COVID policy

AI model detects COVID-19 infection in people’s voices

Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques

MHRA approves bivalent COVID-19 booster vaccine made by Pfizer/BioNTech

Male hypogonadism associated with risk of hospitalization for COVID-19

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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