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Drug-drug or drug-food interactions may offer opportunities to lower costs

Exploiting interactions between food and drugs could dramatically lower the rapidly rising costs of several anticancer drugs, and perhaps many other medications, two cancer-pharmacology specialists suggest in a commentary in the July 16, 2007, issue of the Journal of Clinical Oncology.

17 Jul 2007

Depression and smoking link

Ever wonder why smoking and depression seem to go together? A Saint Louis University School of Public Health researcher finds the connection is genetic.

17 Jul 2007

Insights into side effects of HIV protease inhibitors

UCLA scientists, along with collaborators from Purdue University, have demonstrated that HIV protease inhibitors, crucial drugs for HIV treatment block a cellular enzyme important for generating the structural scaffolding for the cell nucleus.

17 Jul 2007

COPD patients taking inhaled steroids are at greater risk for severe pneumonia

Patients with Chronic Obstructive Pulmonary Disease (COPD) are increasingly being prescribed inhaled corticosteroids to control exacerbations of the disease, but a new study finds that the anti-inflammatory drugs increase the chances that these patients will be hospitalized for pneumonia.

17 Jul 2007

Many doctors not frustrated that patients can't lower cholesterol, despite cardiovascular risks

Family doctors don’t always feel that they can achieve healthy cholesterol levels in their patients even though they are aware of the dangers of cardiovascular disease, according to an international survey of practitioners published in the July issue of IJCP, the International Journal of Clinical Practice.

17 Jul 2007

Protein km23 - potential target for ovarian cancer treatment

A traffic cop protein in the cell may have an even more important role: transporting a messenger protein that tells components in the nucleus to stop cell growth.

17 Jul 2007

Researchers identify new combination therapy that promotes cancer cell death

Researchers at the University of Pennsylvania School of Medicine identified a combination therapy as a way to sensitize resistant human cancer cells to a treatment currently being tested in clinical trials They propose that the therapy may help to selectively eliminate cancer cells while leaving healthy cells intact, providing a cancer treatment with fewer side effects.

17 Jul 2007

New hope for childhood cancer sufferers

Scientists investigating drug therapies for children with Acute Lymphoblastic Leukaemia (ALL) have presented new data demonstrating for the very first time that a small molecule called ABT-737 can increase the effectiveness of standard therapies.

17 Jul 2007

Latest in HIV/TB research

With HIV infection driving a deadly resurgence of tuberculosis (TB), a new publication provides up-to-date recommendations for clinicians facing the many challenges of treating patients with both of these two complex diseases.

17 Jul 2007

Analysis of diabetes drugs

Most oral medications prescribed for type 2 diabetes are similarly effective for reducing blood glucose, but the drug metformin is less likely to cause weight gain and may be more likely than other treatments to decrease so-called bad cholesterol, according to a report funded by HHS Agency for Healthcare Research and Quality.

17 Jul 2007

Myeloid-derived suppressor cells suppress anti-tumor response to cancer

Scientists at Johns Hopkins and elsewhere say they have mapped out an escape route that cancers use to evade the body's immune system, allowing the disease to spread unchecked.

17 Jul 2007

Tackling counterfeit Chinese pharmaceuticals

Agencies worldwide are cracking down on counterfeit pharmaceuticals, and much of the focus has been on China, where an official was recently executed for approving fake medicines.

17 Jul 2007

New hope for insulin dependent diabetes cure

A diagnosis of type I diabetes means a life sentence of medical follow-up.

17 Jul 2007

Gene detectives discover culprit for type 1 diabetes

Researchers at the Children's Hospital of Philadelphia and McGill University in Montreal have discovered a gene they believe is the culprit in a person developing type 1 diabetes.

16 Jul 2007

Sequential and combination chemotherapy equally effective in treating advanced colorectal cancer

Many patients with incurable advanced colorectal cancer could be offered a more gentle treatment strategy starting with a single chemotherapy drug, as an alternative to current standard initial combination chemotherapy, without compromising their survival.

16 Jul 2007

Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer

The number of lymph nodes that contain evidence of cancer is the best predictor of the effectiveness of adding chemotherapy and radiation to a treatment plan prior to surgery in individuals with oesophageal cancer, according to a study published last month in the Annals of Surgery.

16 Jul 2007

New gene found for type 1 diabetes in children

Pediatrics researchers at The Children's Hospital of Philadelphia and McGill University in Montreal have identified a gene variant that raises a child's risk for type 1 diabetes, formerly called juvenile diabetes.

16 Jul 2007

Hope for cure for insulin-dependent diabetes

A diagnosis of type I diabetes means a life sentence of medical follow-up. While treatments have become simpler and less restrictive in recent years, they are still a burden, especially for young patients.

16 Jul 2007

DNA' s double helix shape explained

Researchers at Duke University's Pratt School of Engineering have uncovered a missing link in scientists' understanding of the physical forces that give DNA its famous double helix shape.

13 Jul 2007

New target for muscular dystrophy drug therapy

Researchers at the University of Pennsylvania School of Medicine report how the gene for utrophin, which codes for a protein very similar to dystrophin, the defective protein in Duchenne muscular dystrophy (DMD), puts the brakes on its own expression in muscle cells, thereby suggesting a new target for treatment.

13 Jul 2007