Endoplasmic reticulum (ER) News and Research

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Study shows that age and sleep deprivation induce cellular stress in pancreas

Sleep, or the lack of it, seems to affect just about every aspect of human physiology. Yet, the molecular pathways through which sleep deprivation wreaks its detrimental effects on the body remain poorly understood.

12 Dec 2013

Study reveals pathogenic factor that triggers prion and neurodegenerative diseases

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein.

12 Dec 2013

Study: Uncontrolled epilepsy associated with higher healthcare utilization

Seizures in people with epilepsy are commonly treated with anti-epileptic drugs (AEDs) but 30-40 percent do not achieve adequate seizure control, predisposing them to severe health risks, impaired quality of life and higher healthcare costs.

9 Dec 2013

Ventana now offers FDA-cleared image analysis and digital read application for IHC breast markers

Ventana Medical Systems, Inc., a member of the Roche Group, received 510(k) clearance from the U.S. Food and Drug Administration for the Companion Algorithm ER (SP1) image analysis algorithm used with the VENTANA iScan Coreo scanner running Virtuoso software. With this clearance, Ventana is now the only company in the industry offering a comprehensive portfolio of FDA-cleared image analysis algorithms and digital read applications for the five key immunohistochemistry breast markers.

5 Dec 2013

First Edition: December 5, 2013

Today's headlines include reports about how President Barack Obama is trying to connect with young adults and urge them to sign up for health coverage.

5 Dec 2013

PES' ESRD Prevention Program effectively identifies patients with early stage renal disease

Patient Engagement Systems, a nationally recognized leader in developing technology to identify, and monitor individuals with chronic kidney disease, today introduced the Patient Engagement Systems' ESRD Prevention Program which uses proprietary technology including automated physician-patient engagement, analytics, and decision support tools to identify patients with undiagnosed chronic kidney disease and tools to monitor them in order to prevent or delay the progression to ESRD.

3 Dec 2013

Walk-in clinics staffed by nurses can reduce health care costs, says URI professor

People who don't have health insurance are often forced to seek treatment at hospital emergency rooms for colds, body aches and other routine illnesses. Those visits cost patients, hospitals and taxpayers millions of dollars every year.

28 Nov 2013

FDA accepts Purdue Pharma's Targiniq ER Tablets CII NDA for review

Purdue Pharma L.P. today announced that the U.S. Food and Drug Administration has accepted for review a New Drug Application for Targiniq ER (oxycodone HCl/naloxone HCl controlled-release) Tablets CII, for the management of chronic pain.

27 Nov 2013

NEXAVAR tablets receive FDA approval for treatment of patients with thyroid cancer

Bayer HealthCare and Onyx Pharmaceuticals, Inc., an Amgen subsidiary, today announced that the U.S. Food and Drug Administration has approved a supplemental New Drug Application for the oral multi-kinase inhibitor NEXAVAR (sorafenib) tablets for the treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment.

23 Nov 2013

Viewpoints: Obamacare has resisted death throes before; website success stories from 3 governors; health law taking a toll on choice of doctors in Medicare Advantage

The first time Obamacare seemed finished, doomed, doornail-dead, the voters of Massachusetts played the would-be executioner. In January 2010, they sent a pickup-driving Republican to the Senate to fill Ted Kennedy's seat, apparently depriving the health care bill of its crucial 60th vote and sending Democrats scrambling for a Plan B. ... the deeper force at work, the reason that these near-death experiences keep happening, isn't a website or a broken presidential promise. It's a problem inherent to contemporary liberalism, which is that liberals' proudest achievement, the modern welfare state, tends to resist, corrupt and baffle their efforts at comprehensive reform (Ross Douthat, 11/16).

19 Nov 2013

Medical image exchange: an interview with Willie Tillery, CEO of Accelarad

Accelarad’s team first recognized the need for the virtualization of radiology more than 10 years ago. Over the past six years, the industry has readily adopted cloud-based medical image exchanges, as evidenced by the thousands of physicians who share nearly half a billion images via Accelarad each year.

18 Nov 2013

Small molecule compound shows significant success in controlling polyomaviruses

A team of scientists reports that a small molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened.

15 Nov 2013

Stem cells from Wolfram syndrome patients used to elucidate beta-cell failure pathway in diabetes

Scientists from the New York Stem Cell Foundation Research Institute and Columbia University Medical Center have used stem cells created from the skin of patients with a rare form of diabetes—Wolfram syndrome—to elucidate an important biochemical pathway for beta-cell failure in diabetes. The findings by Linshan Shang and colleagues were published today in Diabetes.

13 Nov 2013

Targeted radiotherapy could offer viable alternative to current procedures for breast cancer

Two new studies, published in The Lancet and The Lancet Oncology, show that targeted radiotherapy delivered during surgery could offer a viable alternative to current procedures – which require women to attend daily radiotherapy sessions for weeks after surgery – for some women undergoing surgery for early breast cancer.

11 Nov 2013

Researchers study quality, effectiveness and safety of generic drugs used to treat depression

Researchers at Washington University School of Medicine in St. Louis are studying the quality, effectiveness and safety of generic drugs used to treat depression.

4 Nov 2013

Special issue highlights rapid advances in myopia research

New research on myopia-how it develops, risk and protective factors, and potentially effective measures for prevention and treatment are reported across twenty articles in the November issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

30 Oct 2013

New study reveals striking data about misuse of painkillers and sedatives by teens, young adults

With prescription drug abuse at epidemic levels nationwide, and overdoses killing more people than auto accidents in many states, a new University of Michigan study provides striking new data about the misuse of potent prescription painkillers and sedatives by teens and young adults.

30 Oct 2013

ERs may begin to receive more reimbursement once Obamacare gets fully implemented

Emergency departments, which have suffered shortfalls in reimbursement for decades due to the high rate of uninsurance in the United States, may begin receiving "considerably more" reimbursement once the Affordable Care Act (also known as Obamacare) is fully implemented.

29 Oct 2013

Hands-free ultrasound device with clot-busting drug safe for ischemic stroke patients

A study led by researchers at The University of Texas Health Science Center at Houston (UTHealth) showed that a hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke patients.

25 Oct 2013

Study finds that homeless people visit ER 8 times as often as general population

Although homeless people account for a small proportion of Emergency Department visits, a small group of them are extremely high users and have multiple complex health care needs, new research has found.

23 Oct 2013